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Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 319:R526-R540
The goal of this study was to examine the effects of systemic morphine on the pattern and morphology of gasping breathing during respiratory autoresuscitation from transient anoxia. We hypothesized that systemic morphine levels sufficient to cause si
Autor:
Talita Rojas Sanches, José Manuel Condor Capcha, Maria Claudia Irigoyen, Margoth Ramos Garnica, Paulo Sampaio Gutierrez, Roberto de Souza Moreira, Irene L. Noronha, Lucia Andrade
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Patients undergoing coronary angiography after myocardial infarction (MI) often develop cardiac and renal dysfunction. We hypothesized that the apolipoprotein A-I mimetic peptide 4F (4F) would prevent those complications. Male Wistar rats were fed a
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Psychomotor stimulants are prescribed for many medical conditions, including obesity, sleep disorders, and attention-deficit/hyperactivity disorder. However, despite their acknowledged therapeutic utility, these stimulants are frequently abused, and
Autor:
William J. Pearce, Andre Obenaus, Elizabeth Haddad, Lara M. Durrant, P. Naomi Franco, Adam Vergara, Desirelys Carreon, Catherine Cascavita
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
This study explored the hypothesis that late gestational reduction of corticosteroids transforms the cerebrovasculature and modulates postnatal vulnerability to mild hypoxic-ischemic (HI) injury. Four groups of Sprague-Dawley neonates were studied: 1
Autor:
Olena Wojno, Agnieszka Wsol, Agnieszka Cudnoch-Jędrzejewska, Robert Wrzesień, Ewa Szczepanska-Sadowska, Liana Puchalska
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 318:R160-R172
The present study was designed to determine the role of centrally acting oxytocin (OT) in the regulation of blood pressure during chronic mild stress (CMS) in spontaneously hypertensive (SHR; n = 36) and normotensive Wistar-Kyoto (WKY; n = 38) rats.
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Compounds described by humans as “bitter” are sensed by a family of type 2 taste receptors (T2Rs). Previous work suggested that diverse bitter stimuli activate distinct receptors, which might allow for perceptually distinct tastes. Alternatively,
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 312:R62-R73
High-dose glucocorticoids (GC) induce skeletal muscle atrophy, insulin resistance, and reduced muscle capillarization. Identification of treatments to prevent or reverse capillary rarefaction and metabolic deterioration caused by prolonged elevations
Autor:
Takakazu Yagi, Hirotaka Ueda, Tomoyuki Kuwaki, Ikue Kusumoto-Yoshida, Hideki Kashiwadani, Shouichi Miyawaki, Mayu Suga
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 311:R964-R970
The aim of this study was to clarify the effect of vagal afferent activation on salivation and swallowing-like events. Salivation is part of a reflex induced by stimulation of the oral area during feeding or chewing. Recently, we reported that nausea
Autor:
Maribeth H. Johnson, Adviye Ergul, Trevor Hardigan, Abdul Yasir, Mohammed Abdelsaid, Maha Coucha, Sally El-Shaffey, Weiguo Li
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 311:R466-R477
The antihyperglycemic agent linagliptin, a dipeptidyl peptidase-4 (DPP-IV) inhibitor, has been shown to reduce inflammation and improve endothelial cell function. In this study, we hypothesized that DPP-IV inhibition with linagliptin would improve im
Autor:
Marina T. Durand, Rubens Fazan, Carlos Alberto Aguiar Silva, Helio Cesar Salgado, Kaushik P. Patel, Tomas Teixeira Pinto, Jaci Airton Castania, Renata Maria Lataro
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Chronic heart failure (CHF) is characterized by autonomic dysfunction combined with baroreflex attenuation. The hypotensive and bradycardic responses produced by electrical stimulation of the aortic depressor nerve (ADN) were examined in conscious CH