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Autor:
Alexander Gabor, Frans H. H. Leenen
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 301:R1338-R1349
Intracerebroventricular infusion of Na+-rich artificial cerebrospinal fluid (aCSF) causes larger sympathetic and pressor responses in Dahl salt-sensitive (S) than -resistant (R) or Wistar rats. Enhanced activity of the aldosterone-“ouabain” pathw
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 299:R1326-R1332
Pregnancy-mediated sodium (Na) retention is required to provide an increase in plasma volume for the growing fetus. The mechanisms responsible for this Na retention are not clear. We first used a targeted proteomics approach and found that there were
Autor:
Michel Baum
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 298:R954-R958
Previous studies have shown that in proximal and distal tubule nephron segments, peritubular ANG II stimulates sodium chloride transport. However, ANG II inhibits chloride transport in the medullary thick ascending limb (mTAL). Because ANG II and cat
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 297:R149-R157
Compared to young cohorts, old rats drink less water in response to several thirst-inducing stimuli. In these experiments, we characterized water drinking in response to hypotension and cellular dehydration in young (4 mo), middle-aged adult (12 mo)
Autor:
Alexander Gabor, Frans H. H. Leenen
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 296:R618-R630
Sympathoexcitatory and hypertensive responses to central infusion of Na+-rich artificial cerebrospinal fluid (aCSF) are enhanced by aldosterone and mediated by mineralocorticoid receptors (MRs) and benzamil-blockable Na+ influx, leading to “ouabain
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 293:R1461-R1467
We hypothesized that angiotensin subtype-2 receptor (AT2R) inhibits renal renin biosynthesis in young rats via nitric oxide (NO). We monitored changes in renal NO, cGMP, renal renin content (RRC), and ANG II in 4-wk-old rats in response to low sodium
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 293:R1684-R1692
Cardiomyocyte sodium accumulation after burn injury precedes the development of myocardial contractile dysfunction. The present study examined the effects of burn injury on Na-K-ATPase activity in adult rat hearts after major burn injury and explored
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 293:R1027-R1036
Previous studies demonstrated the inhibitory participation of serotonergic (5-HT) and oxytocinergic (OT) neurons on sodium appetite induced by peritoneal dialysis (PD) in rats. The activity of 5-HT neurons increases after PD-induced 2% NaCl intake an
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 292:R2400-R2405
Previous studies have indicated that 20-hydroxyeicosatetraenoic acid (20-HETE) inhibits Na+transport in the medullary thick ascending loop of Henle (mTALH), but the mechanisms involved remain uncertain. The present study compared the effects of 20-HE
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 292:R1230-R1235
Prenatal administration of dexamethasone causes hypertension in rats when they are studied as adults. Although an increase in tubular sodium reabsorption has been postulated to be a factor programming hypertension, this has never been directly demons