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Autor:
Shaun F. Morrison, Clarissa M. D. Mota, Ellen Paula Santos da Conceição Furber, Christopher J. Madden, Edward Veytsman
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Systemic administration of dopamine (DA) receptor agonists leads to falls in body temperature. However, the central thermoregulatory pathways modulated by DA have not been fully elucidated. Here we identified a source and site of action contributing
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 321:R12-R20
Angiotensin II (ANG II) is a potent vasoconstrictor and may reduce renal blood flow (RBF), causing renal hypoxia. Hypotensive hemorrhage elevates plasma ANG II levels and is associated with increased risk of acute kidney injury. We hypothesized that
Autor:
James E. Blevins, James L. Graham, Ha Khanh Nguyen, Tami Wolden-Hanson, Mélise Marie Edwards, Adam Jay Herbertson, Peter J. Havel, Tomasz Wietecha, Andrew Dale Dodson, Kevin D. O'Brien
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
American journal of physiology. Regulatory, integrative and comparative physiology, vol 320, iss 4
American journal of physiology. Regulatory, integrative and comparative physiology, vol 320, iss 4
Previous studies indicate that oxytocin (OT) administration reduces body weight in high-fat diet (HFD)-induced obese (DIO) rodents through both reductions in food intake and increases in energy expenditure. We recently demonstrated that chronic hindb
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 320:R384-R392
Heat stress, via its effects on muscle intracellular Ca2+ concentrations ([Ca2+]i), has been invoked as a putative therapeutic countermeasure to type 1 diabetes-induced muscle atrophy. Using a circulation- and neurally intact in vivo muscle preparati
Autor:
Brian T. Layden, Congcong He, Anton E. Ludvik, Gautham Oroskar, Medha Priyadarshini, Connor Cole, Barton Wicksteed
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
The free fatty acid receptor 3 (FFA3) is a nutrient sensor of gut microbiota-generated nutrients, the short-chain fatty acids. Previously, we have shown that FFA3 is expressed in β-cells and inhibits islet insulin secretion ex vivo. Here, we determi
Autor:
Elaine Liu, Sergei A. Vinogradov, Andrew J. Baker, Hannah Joo, Kim A. Connelly, Jason T. Maynes, Nikhil Mistry, Austin Read, David F. Wilson, Jessica R Abrahamson, Kerri Thai, Kyle Chin, Richard E. Gilbert, Jean-Francois Desjardins, Gregory M. T. Hare, C. David Mazer
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 318:R799-R812
Sensing changes in blood oxygen content ([Formula: see text]) is an important physiological role of the kidney; however, the mechanism(s) by which the kidneys sense and respond to changes in [Formula: see text] are incompletely understood. Accurate m
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Psychomotor stimulants are prescribed for many medical conditions, including obesity, sleep disorders, and attention-deficit/hyperactivity disorder. However, despite their acknowledged therapeutic utility, these stimulants are frequently abused, and
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 317:R407-R417
High-altitude natives have evolved to overcome environmental hypoxia and provide a compelling system to understand physiological function during reductions in oxygen availability. The sympathoadrenal system plays a key role in responses to acute hypo
Autor:
Michelle L. Halls, Anna L. Sandström, Dana S. Hutchinson, Masaaki Sato, Nodi Dehvari, Jon Merlin, Robert I. Csikasz, Roger J. Summers, Anette I. Öberg, Saori Mukaida, Jessica M. Olsen, Tore Bengtsson, Bronwyn A Evans, Martina Kocan
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 316:R666-R677
The type 2 diabetes epidemic makes it important to find insulin-independent ways to improve glucose homeostasis. This study examines the mechanisms activated by a dual β2-/β3-adrenoceptor agonist, BRL37344, to increase glucose uptake in skeletal mu
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 315:R1167-R1182
The paraventricular nucleus of the hypothalamus (PVN) contributes to both autonomic and neuroendocrine function. PVN lesion or inhibition blunts cardiorespiratory responses to peripheral chemoreflex activation, suggesting that the PVN is required for