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Autor:
Elaine M. Worcester, Kristin J. Bergsland, Jaime Baylock, Daniel L. Gillen, Benjamin Ko, Fredric L. Coe, Andrew P. Evan, Daniel Clark
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 309:R85-R92
Idiopathic hypercalciuria (IH) is a common familial trait among patients with calcium nephrolithiasis. Previously, we have demonstrated that hypercalciuria is primarily due to reduced renal proximal and distal tubule calcium reabsorption. Here, using
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 299:R1326-R1332
Pregnancy-mediated sodium (Na) retention is required to provide an increase in plasma volume for the growing fetus. The mechanisms responsible for this Na retention are not clear. We first used a targeted proteomics approach and found that there were
Autor:
Michel Baum
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 298:R954-R958
Previous studies have shown that in proximal and distal tubule nephron segments, peritubular ANG II stimulates sodium chloride transport. However, ANG II inhibits chloride transport in the medullary thick ascending limb (mTAL). Because ANG II and cat
Autor:
Lijun Tang, Nancy K. Valego, Mark C. Chappell, Philip Deibel, James C. Rose, Jianli Bi, Luke C. Carey, James Perrott, Xiurong Sun, Jorge P. Figueroa
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 296:R309-R317
Exposure to clinically relevant doses of glucocorticoids during fetal life increases blood pressure in adult male and female sheep. The purpose of this study was to evaluate the effects of prenatal exposure to betamethasone at 80–81 days of gestati
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 292:R2400-R2405
Previous studies have indicated that 20-hydroxyeicosatetraenoic acid (20-HETE) inhibits Na+transport in the medullary thick ascending loop of Henle (mTALH), but the mechanisms involved remain uncertain. The present study compared the effects of 20-HE
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 292:R1230-R1235
Prenatal administration of dexamethasone causes hypertension in rats when they are studied as adults. Although an increase in tubular sodium reabsorption has been postulated to be a factor programming hypertension, this has never been directly demons
Autor:
Raymond Quigley, Michel Baum
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 289:R1659-R1664
We have previously shown that neonate rabbit tubules have a lower chloride permeability but comparable mannitol permeability compared with adult proximal tubules. The surprising finding of lower chloride permeability in neonate proximals compared wit
Autor:
Daniel R. Kapusta, Helmut B. Gottlieb
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 289:R1289-R1296
Intracerebroventricular injection of κ-opioid agonists produces diuresis, antinatriuresis, and a concurrent increase in renal sympathetic nerve activity (RSNA). The present study examined whether endogenous central κ-opioid systems contribute to th
Autor:
Philip A. Veillette, Graham Young
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 288:R1598-R1605
A method to culture tissue explants of the intestine from freshwater-adapted sockeye salmon ( Oncorhynchus nerka) was developed to assess possible direct effects of cortisol on Na+-K+-ATPase activity. As judged by several criteria, explants from pylo
Autor:
Neil E. Rowland, Emily C. Crews
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 288:R638-R644
It is known that mice injected peripherally with ANG II do not show a drinking response but that cFos immunoreactivity (ir) is induced in brain regions similar to those in rats. We now show in Crl:CD1(ICR) mice that peripheral injection of the ANG II