Zobrazeno 1 - 10
of 118
pro vyhledávání: ''
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 321:R12-R20
Angiotensin II (ANG II) is a potent vasoconstrictor and may reduce renal blood flow (RBF), causing renal hypoxia. Hypotensive hemorrhage elevates plasma ANG II levels and is associated with increased risk of acute kidney injury. We hypothesized that
Autor:
Elaine Liu, Sergei A. Vinogradov, Andrew J. Baker, Hannah Joo, Kim A. Connelly, Jason T. Maynes, Nikhil Mistry, Austin Read, David F. Wilson, Jessica R Abrahamson, Kerri Thai, Kyle Chin, Richard E. Gilbert, Jean-Francois Desjardins, Gregory M. T. Hare, C. David Mazer
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 318:R799-R812
Sensing changes in blood oxygen content ([Formula: see text]) is an important physiological role of the kidney; however, the mechanism(s) by which the kidneys sense and respond to changes in [Formula: see text] are incompletely understood. Accurate m
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 309:R892-R901
Renal autoregulation is impaired in early (1 wk) diabetes mellitus (DM) induced by streptozotocin, but effective in established DM (4 wk). Furthermore nitric oxide synthesis (NOS) inhibition with NG-nitro-l-arginine methyl ester (l-NAME) significantl
Autor:
Jane F. Reckelhoff, Andrew D. Smith, Joey P. Granger, Elizabeth Bui, Rodrigo O Maranon, Howei Zhang, R. Lucas Thomas, Jussara M. do Carmo, Roberta Lima, Mohadetheh Moulana, Frank T. Spradley, John E. Hall
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 308:R708-R713
Women with polycystic ovary syndrome (PCOS) have hyperandrogenemia and increased prevalence of risk factors for cardiovascular disease, including elevated blood pressure. We recently characterized a hyperandrogenemic female rat (HAF) model of PCOS [c
Autor:
C. David Mazer, John G. Sled, R. Mark Henkelman, Albert K. Y. Tsui, Neville Chan, Lindsay S. Cahill, Gregory M. T. Hare, Keith M. Lee, Elaine Liu, Philip A. Marsden, Yu-Qing Zhou
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 307:R13-R25
Tissue hypoxia likely contributes to anemia-induced organ injury and mortality. Severe anemia activates hypoxia-inducible factor (HIF) signaling by hypoxic- and neuronal nitric oxide (NO) synthase- (nNOS) dependent mechanisms. However, organ-specific
Autor:
Rolf M. Nüsing, Kirsten Madsen, Boye L. Jensen, Mette Staehr, Pernille B. Lærkegaard Hansen, Paul M. Vanhoutte
Publikováno v:
Staehr, M, Hansen, P B L, Madsen, K, Vanhoutte, P M, Nüsing, R M & Jensen, B L 2013, ' Deletion of Cyclooxygenase-2 in the mouse increases arterial blood pressure with no impairment in renal NO production in response to chronic high salt intake ', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 304, no. 10, pp. R899-R907 . https://doi.org/10.1152/ajpregu.00103.2012
Experiments were designed to test the hypothesis that cyclooxygenase-2 (COX-2) activity attenuates the blood pressure increase during high NaCl intake by stimulation of endothelial nitric oxide synthase (eNOS)-mediated NO synthesis in the kidney medu
Autor:
Jan M. Williams, Kathryn M. Dunn, Annette J. Dahly-Vernon, Sydney R. Murphy, Chun Cheng Andy Chen, Steven R. Ledbetter, Richard J. Roman
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 303:R57-R69
This study examined the effects of anti-TGF-β antibody (1D11) therapy in Dahl S (S) rats fed a 4% NaCl diet. Baseline renal expression of TGF-β1 and the degree of injury were lower in female than male S rats maintained on a 0.4% NaCl diet. 4% NaCl
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 302:R868-R875
We have previously shown that fetal uninephrectomy (uni-x) at 100 days of gestation (term = 150 days) in male sheep results in a 30% nephron deficit, reduction in glomerular filtration rate (GFR) and renal blood flow, and elevation in arterial pressu
Autor:
William H. Ray, Keisa W. Mathis, Michael J. Ryan, Marcia Venegas-Pont, Radu Iliescu, Porter H. Glover
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 301:R1286-R1292
Inflammation and immune system dysfunction contributes to the development of cardiovascular and renal disease. Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disorder that carries a high risk for both renal and cardiovascular
Autor:
Robert De Matteo, Reetu R. Singh, Simone Zanini, John F. Bertram, Andrew J. Jefferies, D. Arena, Karen M. Moritz, Miodrag Dodic, Megan Elizabeth Probyn, Roger G. Evans, E. Marelyn Wintour
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 301:R500-R509
Treatment of the pregnant ewe with glucocorticoids early in pregnancy results in offspring with hypertension. This study examined whether glucocorticoids can reduce nephron formation or alter gene expression for sodium channels in the late gestation