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Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 310:R337-R345
The oxytocin (OT) and vasopressin (VP) neurons of the supraoptic nucleus (SON) demonstrate characteristics of “metabolic sensors”. They express insulin receptors and glucokinase (GK). They respond to an increase in glucose and insulin with an inc
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 309:R1292-R1300
The brain of mammalian hibernators is naturally protected. Hibernating ground squirrels undergo rapid and extreme changes in body temperature and brain perfusion as they cycle between lengthy torpor bouts and brief periods of euthermia called interbo
Autor:
Elaine M. Worcester, Kristin J. Bergsland, Jaime Baylock, Daniel L. Gillen, Benjamin Ko, Fredric L. Coe, Andrew P. Evan, Daniel Clark
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 309:R85-R92
Idiopathic hypercalciuria (IH) is a common familial trait among patients with calcium nephrolithiasis. Previously, we have demonstrated that hypercalciuria is primarily due to reduced renal proximal and distal tubule calcium reabsorption. Here, using
Autor:
Jane F. Reckelhoff, Andrew D. Smith, Joey P. Granger, Elizabeth Bui, Rodrigo O Maranon, Howei Zhang, R. Lucas Thomas, Jussara M. do Carmo, Roberta Lima, Mohadetheh Moulana, Frank T. Spradley, John E. Hall
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 308:R708-R713
Women with polycystic ovary syndrome (PCOS) have hyperandrogenemia and increased prevalence of risk factors for cardiovascular disease, including elevated blood pressure. We recently characterized a hyperandrogenemic female rat (HAF) model of PCOS [c
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 307:R538-R545
Increased circulating fetal glucose and insulin concentrations are potential inhibitors of fetal lung maturation and may contribute to the pathogenesis of respiratory distress syndrome (RDS) in infants of diabetic mothers. In this study, we examined
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 307:R354-R360
We hypothesized that prostaglandin E2 (PGE2) stimulates amniotic fluid transport across the amnion by upregulating vascular endothelial growth factor (VEGF) expression in amnion cells and that amniotic PGE2 concentration correlates positively with in
Autor:
Rolf M. Nüsing, Kirsten Madsen, Boye L. Jensen, Mette Staehr, Pernille B. Lærkegaard Hansen, Paul M. Vanhoutte
Publikováno v:
Staehr, M, Hansen, P B L, Madsen, K, Vanhoutte, P M, Nüsing, R M & Jensen, B L 2013, ' Deletion of Cyclooxygenase-2 in the mouse increases arterial blood pressure with no impairment in renal NO production in response to chronic high salt intake ', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 304, no. 10, pp. R899-R907 . https://doi.org/10.1152/ajpregu.00103.2012
Experiments were designed to test the hypothesis that cyclooxygenase-2 (COX-2) activity attenuates the blood pressure increase during high NaCl intake by stimulation of endothelial nitric oxide synthase (eNOS)-mediated NO synthesis in the kidney medu
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 304:R636-R643
This study assessed the role of the extracellular signal-regulated kinase (ERK) signaling pathway on the previously observed enhanced cortisol secretion in response to adrenocorticotropic hormone (ACTH) treatment in fetal adrenocortical cells (FACs)
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 303:R513-R519
Intrauterine growth restriction is associated with increased fetal glucocorticoid exposure and an increased risk of adult coronary artery disease. Coronary arteries from sheep exposed to early gestation dexamethasone (Dex) have increased constriction
Autor:
Jan M. Williams, Kathryn M. Dunn, Annette J. Dahly-Vernon, Sydney R. Murphy, Chun Cheng Andy Chen, Steven R. Ledbetter, Richard J. Roman
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 303:R57-R69
This study examined the effects of anti-TGF-β antibody (1D11) therapy in Dahl S (S) rats fed a 4% NaCl diet. Baseline renal expression of TGF-β1 and the degree of injury were lower in female than male S rats maintained on a 0.4% NaCl diet. 4% NaCl