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Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 319:R526-R540
The goal of this study was to examine the effects of systemic morphine on the pattern and morphology of gasping breathing during respiratory autoresuscitation from transient anoxia. We hypothesized that systemic morphine levels sufficient to cause si
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Compounds described by humans as “bitter” are sensed by a family of type 2 taste receptors (T2Rs). Previous work suggested that diverse bitter stimuli activate distinct receptors, which might allow for perceptually distinct tastes. Alternatively,
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 312:R62-R73
High-dose glucocorticoids (GC) induce skeletal muscle atrophy, insulin resistance, and reduced muscle capillarization. Identification of treatments to prevent or reverse capillary rarefaction and metabolic deterioration caused by prolonged elevations
Autor:
Maribeth H. Johnson, Adviye Ergul, Trevor Hardigan, Abdul Yasir, Mohammed Abdelsaid, Maha Coucha, Sally El-Shaffey, Weiguo Li
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 311:R466-R477
The antihyperglycemic agent linagliptin, a dipeptidyl peptidase-4 (DPP-IV) inhibitor, has been shown to reduce inflammation and improve endothelial cell function. In this study, we hypothesized that DPP-IV inhibition with linagliptin would improve im
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 309:R189-R195
Testosterone (TES) and other androgens exert a direct vasorelaxing action on the vasculature in vitro that is structurally specific and independent of cytosolic androgen receptor (AR). The effects of intravenous androgen infusions on mean arterial bl
Autor:
John-Paul Baird, Julia Lord, Christopher Lim, Mariana Palacios, Eduardo Matute, Michael J. LaRiviere, Lindsay A. Grigg
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 301:R1044-R1056
Injections of the melanocortin 3/4 receptor (MCR) agonist melanotan II (MTII) to a variety of brain structures produces anorexia, suggesting distributed brain MCR control of food intake. We performed a detailed analysis of feeding behavior (licking m
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 301:R1011-R1024
The aim of our study was to investigate the anorectic and brain stimulatory effects of various doses of exendin-4 (Ex-4) and to investigate the role of the vagus nerve in Ex-4-induced brain activation. A dose-related increase in c- fos mRNA expressio
Autor:
Bradley J. Behnke, James M. Dominguez, Danielle J. McCullough, Robert T. Davis, John N. Stabley
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 301:R801-R810
Testicular function and associated testosterone concentration decline with advancing age, and an impaired O2 supply may contribute, in part, to this reduction. We hypothesized that there would be a reduced microvascular Po2 (Po2m) in the testes from
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 301:R783-R790
The influence of the sympathetic nervous system (SNS) upon vascular resistance is more profound in muscles comprised predominately of low-oxidative type IIB vs. high-oxidative type I fiber types. However, within muscles containing high-oxidative type
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 298:R43-R50
Insulin detemir is a novel human insulin analog that does not show the usual propensity for weight gain in diabetic patients. We speculated that this beneficial effect could be due to insulin detemir exerting stronger anorectic effects within the bra