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Autor:
Christophe Poirier, Bruce D. Ray, Walter C. Hubbard, John V. Goodpaster, Elena S. Kim, Robert Bittman, Mary Van Demark, Clinton Carroll, Mu Wang, Matthew J. Justice, Kelly S. Schweitzer, Steven X. Chen, Sarah Law, William Kranz, Xianyin Lai, Irina Petrache
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 309:L175-L187
The increased use of inhaled nicotine via e-cigarettes has unknown risks to lung health. Having previously shown that cigarette smoke (CS) extract disrupts the lung microvasculature barrier function by endothelial cell activation and cytoskeletal rea
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 308:L922-L930
Rat pups prenatally exposed to nicotine (PNE) present apneic (lethal ventilatory arrest) responses during severe hypoxia. To clarify whether these responses are of central origin, we tested PNE effects on ventilation and diaphragm electromyography (E
Autor:
Michie Toba, Sachiko Kuriyama, Fumiyuki Takahashi, Kazuhisa Takahashi, Kuniaki Seyama, Shin-ichiro Iwakami, Yoshiteru Morio, Tetsutaro Nagaoka
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 306:L996-L1005
Upregulation of the erythropoietin (EPO)/EPO receptor (EPOR) system plays a protective role against chronic hypoxia-induced pulmonary hypertension (hypoxic PH) through enhancement of endothelial nitric oxide (NO)-mediated signaling. Genistein (Gen),
Autor:
Jennifer M. Haick, Leanne L. Cribbs, Kenneth L. Byron, Lioubov I. Brueggemann, Samantha Neuburg, Shawn Tate, Devjit Singh Randhawa
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 306:L476-L486
KCNQ (Kv7 family) potassium (K+) channels were recently found in airway smooth muscle cells (ASMCs) from rodent and human bronchioles. In the present study, we evaluated expression of KCNQ channels and their role in constriction/relaxation of rat air
Autor:
Alina Boico, Timothy J. McMahon, Gregory M. Palmer, David Irwin, Siqing Shan, Andrew N. Fontanella, Karyn L. Hamilton, Gert Blueschke, Thies Schroeder, Gabi Hanna, Daniel R. Radiloff, Claude A. Piantadosi, Yulin Zhao, Mark W. Dewhirst
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Intravital microscopy of the pulmonary microcirculation in research animals is of great scientific interest for its utility in identifying regional changes in pulmonary microcirculatory blood flow. Although feasibility studies have been reported, the
Autor:
Bo Huei Lin, Hui Chun Huang, Jia Jhen Chiu, Hui Fen Chiu, Chih Ching Chang, Chun Yuh Yang, Shan Ling Chen
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 302:L755-L763
Hepatocyte growth factor (HGF) is a potent mitogen and motogen for various epithelial cells. The present study aimed to explore the role of HGF and c-Met receptor in ultrafine carbon particle-induced alveolar type II epithelial (type II) cell prolife
Autor:
Max H. Cake, Jolanta E. Damas
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 301:L966-L974
Type II pneumocytes are responsible for the synthesis and secretion of pulmonary surfactant, which reduces surface tension in lung alveoli, thus decreasing their tendency to collapse during expiration. For this effect to be sustained, the integrity o
Autor:
Amard J. Abcejo, Y. S. Prakash, Alecia Stewart, Lucas W. Meuchel, Dan F. Smelter, Michael A. Thompson, Richard J. Martin, Syed I. A. Zaidi
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 301:L91-L98
Neurally derived tachykinins such as substance P (SP) play a key role in modulating airway contractility (especially with inflammation). Separately, the neurotrophin brain-derived neurotrophic factor (BDNF; potentially derived from nerves as well as
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 300:L710-L717
Perinatal exposure to maternal smoke is associated with adverse pulmonary effects, including reduced lung function and increased incidence of asthma. However, the mechanisms underlying these effects are unknown, and there is no effective preventive a
Autor:
Shu Qiang Sun, Fengying Li, Louisa Balazs, Muthusamy Thangavel, Joseph Kaminsky, Rennolds S. Ostrom, Xiaoqiu Liu
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 298:L819-L829
Pulmonary fibroblasts regulate extracellular matrix production and degradation and are critical in maintenance of lung structure, function, and repair, but they also play a central role in lung fibrosis. cAMP-elevating agents inhibit cytokine- and gr