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Autor:
Martina Gentzsch, Nancy L. Quinney, Imron G. Chaudhry, Deborah M. Cholon, Scott A. Houck, Scott H. Randell, Hong Yu Ren, Pattarawut Sopha, Jhuma Das, Douglas M. Cyr, Nikolay V. Dokholyan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 311:L550-L559
Cystic fibrosis (CF) is a lethal recessive genetic disease caused primarily by the F508del mutation in the CF transmembrane conductance regulator (CFTR). The potentiator VX-770 was the first CFTR modulator approved by the FDA for treatment of CF pati
Autor:
Masanori Nakanishi, Akira Koarai, Tomohiro Ichikawa, Yoshiaki Minakata, Kanako Furukawa, Satoru Yanagisawa, Masakazu Ichinose, Hisatoshi Sugiura, Keiichiro Akamatsu, Tsunahiko Hirano, Takashi Kikuchi, Hiroki Kawabata, Kazuto Matsunaga
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 302:L764-L774
The anti-inflammatory effects of theophylline have been reported to include inhibition of the release of proinflammatory mediators from macrophages and neutrophils. Overproduction of reactive nitrogen species (RNS) has been reported in the airways of
Autor:
Lorna Zlock, Anna Y. Lao, Vijay Dasari, Walter E. Finkbeiner, Jonathan Widdicombe, Masatoshi Morikawa
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 301:L402-L414
—We investigated how cystic fibrosis (CF) alters the relationship between Cl−and mucin secretion in cultures of non-CF and CF human tracheobronchial gland mucous (HTGM and CFTGM, respectively) cells. Biochemical studies showed that HTMG cells sec
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 297:L1002-L1011
Studies have been carried out previously to determine whether mesenchymal stem cells (MSC) influence the progression of pulmonary fibrosis. Here, we asked whether MSC (derived from mouse bone marrow and human umbilical cord blood) produce factors tha
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 294:L131-L138
Mechanisms by which β-adrenergic receptor (βAR) agonists inhibit proliferation of human airway smooth muscle (HASM) cells were investigated because of their potential relevance to smooth muscle hyperplasia in asthma. We hypothesized that βAR agoni
Autor:
Haishan Xu, Shijian Chu
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 293:L1454-L1462
Amiloride-sensitive epithelial sodium channel (ENaC) is a major sodium channel in the lung facilitating fluid absorption. ENaC is composed of α-, β-, and γ-subunits, and the α-subunit is indispensable for ENaC function in the lung. In human lungs
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 287:L928-L935
Prostasin is a tryptic peptidase expressed in prostate, kidney, lung, and airway. Mammalian prostasins are related to Xenopus channel-activating protease, which stimulates epithelial Na+channel (ENaC) activity in frogs. In human epithelia, prostasin
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 286:L81-L86
Lung cancer is the most common visceral malignancy in males, with rapidly increasing incidence in females, and a devastatingly poor prognosis. Transforming growth factor (TGF)-β has been shown to induce senescence in A549 lung cancer cells, and both
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 284:L501-L507
Primary cultures of rat type II alveolar epithelial cells (AECs) or human AEC-derived A549 cells, when exposed to bleomycin (Bleo), exhibited concentration-dependent apoptosis detected by altered nuclear morphology, fragmentation of DNA, activation o
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 280:L127-L133
Human airway epithelial cell release of interleukin (IL)-6 in response to lipid mediators was studied in an airway cell line (BEAS-2B). Prostaglandin (PG) E2(10−7M) treatment caused an increase in IL-6 release at 2, 4, 8, and 24 h. IL-6 release int