Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Anna Mae Diehl"'
Autor:
Suvarthi Das, Anna Mae Diehl, Saurabh Chatterjee, Firas Alhasson, Mitzi Nagarkatti, Ratanesh Seth, Sahar Pourhoseini, Gregory A. Michelotti, Diptadip Dattaroy
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 308:G298-G312
Hepatic fibrosis in nonalcoholic steatohepatitis (NASH) is the common pathophysiological process resulting from chronic liver inflammation and oxidative stress. Although significant research has been carried out on the role of leptin-induced NADPH ox
Autor:
Maria B. Kadiiska, Suvarthi Das, Saurabh Chatterjee, Anna Mae Diehl, Ratanesh Seth, Ashutosh Kumar, Gregory A. Michelotti
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 305:G950-G963
Recent studies indicate that metabolic oxidative stress, autophagy, and inflammation are hallmarks of nonalcoholic steatohepatitis (NASH) progression. However, the molecular mechanisms that link these important events in NASH remain unclear. In this
Autor:
Youngmi Jung, Debra L. Sudan, Marcos Rojkind, Anna Mae Diehl, Liu Yang, Cynthia A. Moylan, Wing-Kin Syn, Jason K. Sicklick, Rafal P. Witek, Steve S. Choi, Alessia Omenetti, Gregory A. Michelotti
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 297:G1093-G1106
Myofibroblastic hepatic stellate cells (MF-HSC) are derived from quiescent hepatic stellate cells (Q-HSC). Q-HSC express certain epithelial cell markers and have been reported to form junctional complexes similar to epithelial cells. We have shown th
Autor:
Anna Mae Diehl, Elizabeth Hernandez Perez, Marcos Rojkind, Steve S. Choi, Shannon J. McCall, Jiawen Huang, Marcia Bustamante, Yin-Xiong Li, Jason K. Sicklick
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 291:G575-G583
Both myofibroblastic hepatic stellate cells (HSC) and hepatic epithelial progenitors accumulate in damaged livers. In some injured organs, the ability to distinguish between fibroblastic and epithelial cells is sometimes difficult because cells under
Autor:
Alaa Melhem, Marzena Zdanowicz, Montserrat Caballero, Anna Mae Diehl, Yin-Xiong Li, Jiawen Huang, Jeffrey H. Fair, Randall McClelland, John W. Ludlow, Lola M. Reid, Jason K. Sicklick, Eva Schmelzer
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 290:G859-G870
Hedgehog signaling through its receptor, Patched, activates transcription of genes, including Patched, that regulate the fate of various progenitors. Although Hedgehog signaling is required for endodermal commitment and hepatogenesis, the possibility
Autor:
Anna Mae Diehl
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 282:G1-G5
Macrophage products, such as cytokines, prostanoids, nitric oxide, and reactive oxygen intermediates, influence the function and viability of macrophages and neighboring cells. Given that the liver has one of the largest resident macrophage populatio
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 281:G382-G392
Fatty livers are sensitive to lipopolysaccharide (LPS) damage. This study tests the hypothesis that this vulnerability occurs because protective, antiapoptotic mechanisms are not upregulated appropriately. Genetically obese, leptin-deficient ob/ob mi
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 275:G696-G704
Ethanol ingestion may interrupt the proregenerative signal transduction that is initiated by injury-related cytokines such as tumor necrosis factor (TNF)-alpha and TNF-alpha- inducible cytokines including interleukin (IL)-6. To test this theory, live
Autor:
John Westwick, Anna Mae Diehl, S. Q. Yang, Ming Yin, J. Fleckenstein, Cynthia A. Bradham, David A. Brenner
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 271:G780-G790
Adenosine 3',5'-cyclic monophosphate (cAMP) prevents epidermal growth factor (EGF)-induced DNA synthesis in many types of cultured cells, including hepatocytes, but its effects on cellular proliferation in vivo are unknown. This study compares the ef
Publikováno v:
Europe PubMed Central
Although previous work suggests that tumor necrosis factor-alpha (TNF) promotes liver regeneration after partial hepatectomy (PH), the source of TNF is unknown. If Kupffer cells release TNF after PH, then Kupffer cell depletion by gadolinium chloride