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Autor:
Tomonori Aoyama, Kazuyoshi Kon, Kenichi Ikejima, Kazuyoshi Takeda, Sumio Watanabe, Satoko Hosoya, Kumiko Arai, Shunhei Yamashina, Hisafumi Yamagata, Sachiko Ishikawa
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 304:G293-G299
To clarify the roles of innate immune cells in liver regeneration, here, we investigated the alteration in regenerative responses after partial hepatectomy (PH) under selective depletion of natural killer (NK) and/or NKT cells. Male, wild-type (WT; C
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G904-G914
Adenosine is a potent modulator of liver fibrosis and inflammation. Adenosine has been shown to regulate such diverse activities as chemotaxis, contraction, and matrix production in hepatic stellate cells (HSC). Ecto-5′-nucleotidase/CD73 [EC 3.1.3.
Autor:
Yohei Saito, Akiko Maruko, Yumi Yamamoto, Yoshikazu Kuwahara, Yosuke Ohtake, Motoi Fukumoto, Tomonori Kobayashi, Manabu Fukumoto, Fumihiko Yamamoto, Yasuhito Ohkubo
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G861-G869
Norepinephrine (NE) amplifies the mitogenic effect of EGF in a rat liver through the adrenergic receptor coupled with G protein, Ghα. Ghα is also known as a transglutaminase 2 (TG2), whose cross-linking activity is implicated in hepatocyte growth.
Autor:
Rebecca Patton, Mohamed Shitia, Samantha N. Minervini, Thomas R. Kolodecik, Abdul Kareem Uduman, E. O. Akinbiyi, Edwin C. Thrower, Martine Alexandre, Fred S. Gorelick, Vikhil Patel, Christine A. Shugrue, Ali Raoof
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G696-G704
Clinical studies indicate that cigarette smoking increases the risk for developing acute pancreatitis. The nicotine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a major cigarette smoke toxin. We hypothesized that NNK could sensi
Autor:
Martine Alexandre, Alexander P. E. Diaz de Villalvilla, Fred S. Gorelick, Edwin C. Thrower, Thomas R. Kolodecik, Christine A. Shugrue, Lawrence H. Young
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 303:G723-G732
The premature activation of digestive enzyme zymogens in the pancreatic acinar cell is an important initiating event in acute pancreatitis. We have previously demonstrated that vacuolar ATPase (vATPase) activity is required for zymogen activation. Ad
Autor:
Koji Yanase, Junichi Yoshii, Tatsuhiro Tsujimoto, Kosuke Kaji, Yasuhide Ikenaka, Mitsuteru Kitade, Ryuichi Noguchi, Yusaku Shirai, Tadashi Namisaki, Hitoshi Yoshiji, Hiroshi Fukui, Yosuke Aihara, Hideto Kawaratani
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 300:G1094-G1104
Angiotensin II type I receptor blocker and iron chelator reportedly exert suppressive effects on nonalcoholic steatohepatitis (NASH) progression, including liver fibrosis and hepatocarcinogenesis. The aim of this study was to elucidate the combined e
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 299:G1097-G1105
Prostaglandin E2 (PGE2) is a proinflammatory lipid mediator produced in excess in inflammatory bowel disease (IBD). PGE2 couples to and signals via four different E-prostanoid (EP) receptors, namely EP1, EP2, EP3, and EP4. In this study, we determine
Autor:
Tomonori Kobayashi, Yasuhito Ohkubo, Akiko Maruko, Yosuke Ohtake, Shinsuke Katoh, Nao Ohishi, Fumihiko Yamamoto
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 299:G106-G114
A neurotransmitter, norepinephrine (NE), amplifies the mitogenic effect of epidermal growth factor (EGF) in the liver by acting on the α1-adrenergic receptor coupled with G protein, Gαh. However, the molecular mechanism is not well understood. Gαh
Autor:
Junqiang Tian, Thomas R. Ziegler, Dean P. Jones, Andrew T. Gewirtz, Prakash Chandra, Li Hao, Ifor R. Willams
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G348-G355
Short bowel syndrome (SBS) is associated with gut barrier dysfunction. We examined effects of dietary glutamine (GLN) or oral antibiotics (ABX) on indexes of gut barrier function in a rat model of SBS. Adult rats underwent a 60% distal small bowel +
Autor:
Ji Hye Seo, Asli Muvaffak, Eiji Nakamura, Regina Ragasa, Songhua Zhang, Susan J. Hagen, Kimihito Tashima
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 296:G319-G329
The physiology of gastric epithelial cells is often studied by using cancer cell lines, which may or may not provide information relevant to normal cells. Because few models exist to study chief cell physiology in vitro, our purpose was to develop pr