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Autor:
Yan Xie, Anirudh Prabu, Jacqueline Chen, Harold J. Boutte, Brad W. Warner, Todd Wylie, Kristine M. Wylie, Marc S. Levin, Nicholas O. Davidson, Deborah C. Rubin, Mackenzie Geisman, Vered Gazit, Phillip I. Tarr
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Loss of functional small bowel surface area causes short bowel syndrome (SBS), intestinal failure, and parenteral nutrition (PN) dependence. The gut adaptive response following resection may be difficult to predict, and it may take up to 2 yr to dete
Autor:
Teresa C. Delgado, Jordi Gracia-Sancho, R. Garcia-Martinez, Erica Lafoz, Eduard Guasch, Genís Campreciós, Glòria Garrabou, María L. Martínez-Chantar, Virginia Hernández-Gea, Héctor García-Calderó, Juan Carlos García-Pagán, Maria Ruart, Aina Anton, Marina Vilaseca
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 321:G603-G616
We have developed two advanced cirrhosis regression experimental models with persistent relevant fibrosis and portal hypertension and an associated deteriorated metabolism that mimic what happens in patients. LI, despite improving metabolism, did not
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 321:G639-G655
Emerging evidence links dietary fiber with altered gut microbiota composition and bile acid signaling in maintaining metabolic health. Yeast β-glucan (Y-BG) is a dietary supplement known for its immunomodulatory effect, yet its impact on the gut mic
Autor:
Eman Ahmed El-Seidi, Gaber Hassan Abdelfattah, Sarah Mahmoud Gamal, Hend Ashour, Aya Aly Ashraf, Heba M. Shawky, Laila A. Rashed, Basma Emad Aboulhoda, Inas A Harb
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 321:G461-G476
This work is investigating functional, histopathological, and molecular changes underlying Helicobacter pylori hypomotility and is correlating these with miR-1, whose disturbance is supposed to be involved in smooth muscle dysfunction and cell prolif
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 321:G527-G542
Gastric peristalsis is critically dependent on an underlying electrical conduction system. Recent years have witnessed substantial progress in clarifying the operations of this system, including its pacemaking units, its cellular architecture, and sl
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 321:G513-G526
A unique integrated investigation on the effect of meal on neurohumoral mechanisms and blood flow redistribution of the mesenteric circulation during orthostasis was investigated. Food ingestion results in cardiovascular hyperdynamism, reduction in c
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 321:G400-G412
Hepatic encephalopathy (HE) is a common, incapacitating complication of cirrhosis that affects many patients with cirrhosis. Although several therapies have proven effective in the treatment and prevention of this condition, several patients continue
Autor:
Shere Paris, Rhonda F. Souza, Rebecca Ekeanyanwu, Stuart J. Spechler, Daniel Davis, Yuwei Jiang
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 321:G335-G343
Obesity is associated with gastroesophageal reflux disease (GERD) and its complications including reflux esophagitis, Barrett’s esophagus, and esophageal adenocarcinoma. Traditionally, these associations have been attributed to the mechanical effec
Autor:
Mircea Iftinca, Vineetha Warriyar, Simon A. Hirota, Pierre-Yves von der Weid, Sonia Rehal, Vivek Krishna Pulakazhi Venu, Christophe Altier, Laurie Alston, Matthew Stephens, Yi-Cheng Tsai, H Szczepanski, Grace Marie Hudson
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 321:G280-G297
Intestinal fibrosis is a common complication of the inflammatory bowel diseases (IBDs), contributing to tissue stiffening and luminal narrowing. Human nuclear receptor 4A 1 (NR4A1) was previously reported to regulate mesenchymal cell function and dam
Autor:
Reyes Gámez-Belmonte, Belén Rivero-Gutiérrez, Fermín Sánchez de Medina, Olga Martínez-Augustin, María Arredondo-Amador
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 321:G157-G170
The study was funded the following grants of the Ministerio de Economía y Competitividad and the Fondo Europeo de Desarrollo Regional FEDER (SAF2011-22922, SAF2011-22812, BFU2014- 57736-P, and AGL2014-58883-R) and Junta de Andalucía (CTS164, CTS235