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Autor:
Grace O. Ciabattoni, Linda J. Lowe-Krentz, Kayli A. Silimperi, Leanna M. Talotta-Altenburg, Yaqiu Li
Publikováno v:
Am J Physiol Cell Physiol
Published studies indicate that TMEM184A is a heparin receptor that interacts with and transduces stimulation from heparin in vascular cells. Previous studies have indicated that heparin increases endothelial nitric oxide synthase (eNOS) activity in
Autor:
Dimitri Laurent, Leonard M. Eisenberg, Sachindra R. Joshi, Elizabeth Sira, Maria A. Mitry, Carol A. Eisenberg, John G. Edwards, Sachin A. Gupte, Britny L. Keith
Publikováno v:
Am J Physiol Cell Physiol
Children surviving cancer and chemotherapy are at risk for adverse health events including heart failure that may be delayed by years. Although the early effects of doxorubicin-induced cardiotoxicity may be attributed to a direct effect on the cardio
Publikováno v:
American Journal of Physiology-Cell Physiology. 316:C449-C455
Microtubule-targeting chemotherapies are linked to impaired cellular metabolism, which may contribute to skeletal muscle dysfunction. However, the mechanisms by which metabolic homeostasis is perturbed remains unknown. Tubulin, the fundamental unit o
Autor:
Larissa Miranda Pereira, Dulce Elena Casarini, Renato A. Mortara, Ana Lucia Campanha-Rodrigues, Maria Claudina Camargo de Andrade, Claudio M. Costa-Neto, Marie Doki Nogueira, Lucas T. Parreiras-e-Silva, Rosana I. Reis
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Hypertension is a global health problem, and angiotensin I (ANG I)-converting enzyme (ACE) inhibitors are largely used to control this pathology. Recently, it has been shown that ACE can also act as a transducer signal molecule when its inhibitors or
Autor:
Ying Luo, Yun-Ling Hao, Ming-Jie Fu, Bao-Quan Wu, Wei Liu, Hong-Lei Zhao, Jin-Jie Liang, Hong-Cheng Fang, Xie-Hui Chen, Xiao-Li Li
Publikováno v:
American Journal of Physiology-Cell Physiology. 315:C380-C388
Recent studies have uncovered the vital roles played by microRNAs in regulating cardiac injury. Among them, the cardiac enriched microRNA-1 (miR-1) has been extensively studied and proven to be detrimental to cardiac myocytes. Hence, the current stud
Publikováno v:
American Journal of Physiology-Cell Physiology. 314:C554-C568
Studies have demonstrated the therapeutic potential of estrogen metabolite 2-methoxyestradiol (2ME2) in several cardiovascular disorders, including hypertension. However, the exact mechanism(s) remains unknown. In this study, primary rat aortic smoot
Autor:
Junhou Lu, Huihui Wang, Xianyang Li, Huanxiang Zhang, Lihong He, Naixin Kang, Qing Yue, Xiaojing Xu
Publikováno v:
American Journal of Physiology-Cell Physiology. 313:C80-C93
Mesenchymal stem cells (MSCs) have the potential to treat various tissue damages, but the very limited number of cells that migrate to the damaged region strongly restricts their therapeutic applications. Full understanding of mechanisms regulating M
Autor:
Qiming Duan, Zijian Xie, Yunhui Xu, Isabel Larre, Namrata Madan, Moumita Banerjee, Sandrine V. Pierre
Publikováno v:
American Journal of Physiology-Cell Physiology
The Na/K-ATPase α1 polypeptide supports both ion-pumping and signaling functions. The Na/K-ATPase α3 polypeptide differs from α1 in both its primary structure and its tissue distribution. The expression of α3 seems particularly important in neuro
Autor:
Meichan Li, Jun Zhang, Qian Jiang, Dejun Sun, Lei Xu, Yuqin Chen, Haiyang Tang, Ziyi Wang, Wenju Lu, Jian Wang, Kai Yang, Xin Duan
Publikováno v:
American Journal of Physiology-Cell Physiology. 311:C482-C497
The ubiquitin-proteasome system is considered to be the key regulator of protein degradation. Bortezomib (BTZ) is the first proteasome inhibitor approved by the US Food and Drug Administration for treatment of relapsed multiple myeloma and mantle cel
Autor:
Hiroya Mizutani, Hisao Yamamura, Makoto Muramatsu, Yuji Imaizumi, Yumiko Hagihara, Yoshiaki Suzuki
Publikováno v:
American Journal of Physiology-Cell Physiology. 310:C740-C747
The pineal glands regulate circadian rhythm through the synthesis and secretion of melatonin. The stimulation of nicotinic acetylcholine receptor due to parasympathetic nerve activity causes an increase in intracellular Ca2+concentration and eventual