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Autor:
Juliann B. Tefft, Jennifer L. Bays, Alex Lammers, Sudong Kim, Jeroen Eyckmans, Christopher S. Chen
Publikováno v:
Am J Physiol Cell Physiol
The Notch pathway regulates complex patterning events in many species and is critical for the proper formation and function of the vasculature. Despite this importance, how the various components of the Notch pathway work in concert is still not well
Autor:
Jing Zhang, Lijia Zhao, Yating Li, Hao Dong, Haisen Zhang, Yu Zhang, Tiantian Ma, Luda Yang, Dengke Gao, Xiaoyu Wang, Haizhen Jiang, Chao Li, Aihua Wang, Yaping Jin, Huatao Chen
Publikováno v:
American Journal of Physiology-Cell Physiology. 322:C231-C245
Autophagy of granulosa cells (GCs) is involved in follicular atresia, which occurs repeatedly during the ovarian development cycle. Several circadian clock genes are rhythmically expressed in both rodent ovarian tissues and GCs. Nuclear receptor subf
Autor:
Francesca Balistrieri, Jason X.-J. Yuan, Haiyang Tang, Xiaomin Wu, Tengteng Zhao, Ziyi Wang, Stephen M. Black, Aleksandra Babicheva, Ankit A. Desai, Jiyuan Chen, Pritesh P. Jain, Ramon J. Ayon, Daniela Valdez-Jasso, Joe G.N. Garcia, Ayako Makino, Marisela Rodriguez, Linda Wu, Keeley S. Ravellette, Jian Wang, John Y.-J. Shyy, Patricia A. Thistlethwaite, Xin Sun
Publikováno v:
Am J Physiol Cell Physiol
Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+ influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung vasculature and its potential pathogenic role in pulmonary art
Publikováno v:
American Journal of Physiology-Cell Physiology. 321:C644-C653
Endothelial dysfunction is associated with the initiation of sepsis-associated organ failure. Bacterial quorum-sensing molecules act as pathogen-associated molecular patterns; however, the effects of quorum-sensing molecules on endothelial cells rema
Autor:
Ioanna Sandvig, Wei-Li Kuan, Vibeke Devold Valderhaug, Axel Sandvig, Ola Huse Ramstad, Stefano Nichele, Kristine Heiney, Geir Bråthen
Publikováno v:
American Journal of Physiology-Cell Physiology
A patterned spread of proteinopathy represents a common characteristic of many neurodegenerative diseases. In Parkinson’s disease (PD), misfolded forms of alpha-synuclein proteins accumulate in hallmark pathological inclusions termed Lewy bodies an
Autor:
Zeugolis, Dimitrios I.
Publikováno v:
American Journal of Physiology-Cell Physiology. 320:C842-C849
The development of therapeutic regenerative medicine and accurate drug discovery cell-based products requires effective, with respect to obtaining sufficient numbers of viable, proliferative, and functional cell populations, cell expansion ex vivo. U
Autor:
Mark Jackman, Samantha Peel
Publikováno v:
American Journal of Physiology-Cell Physiology. 320:C669-C680
Microphysiological systems (MPS), often referred to as “organ-on-chips,” are microfluidic-based in vitro models that aim to recapitulate the dynamic chemical and mechanical microenvironment of living organs. MPS promise to bridge the gap between
Autor:
Chris Gursche, Ashani Montgomery, Franklin Tam, Catherine Cheneval, Sukhkbir Manku, Katrina Besler, Bruce M. McManus, Paul J. Hanson, Jonathan C. Choy, Kevin Rey, Winnie Enns, Stefan Rose-John
Publikováno v:
American Journal of Physiology-Cell Physiology. 320:C554-C565
IL-6 affects tissue protective/reparative and inflammatory properties of vascular endothelial cells (ECs). This cytokine can signal to cells through classic and trans-signaling mechanisms, which are differentiated based on the expression of IL-6 rece
Publikováno v:
Am J Physiol Cell Physiol
Cystic fibrosis (CF) lung disease persists and remains life-limiting for many patients. Elevated high-mobility group box-1 protein (HMGB-1) levels and epithelial sodium channel hyperactivity (ENaC) are hallmark features of the CF lung. The objective
Publikováno v:
Am J Physiol Cell Physiol
In vitro, cell cultures are essential tools in the study of intestinal function and disease. For the past few decades, monolayer cellular cultures, such as cancer cell lines or immortalized cell lines, have been widely applied in gastrointestinal res