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pro vyhledávání: ''
Autor:
Francesca Balistrieri, Jason X.-J. Yuan, Haiyang Tang, Xiaomin Wu, Tengteng Zhao, Ziyi Wang, Stephen M. Black, Aleksandra Babicheva, Ankit A. Desai, Jiyuan Chen, Pritesh P. Jain, Ramon J. Ayon, Daniela Valdez-Jasso, Joe G.N. Garcia, Ayako Makino, Marisela Rodriguez, Linda Wu, Keeley S. Ravellette, Jian Wang, John Y.-J. Shyy, Patricia A. Thistlethwaite, Xin Sun
Publikováno v:
Am J Physiol Cell Physiol
Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+ influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung vasculature and its potential pathogenic role in pulmonary art
Autor:
Chris Gursche, Ashani Montgomery, Franklin Tam, Catherine Cheneval, Sukhkbir Manku, Katrina Besler, Bruce M. McManus, Paul J. Hanson, Jonathan C. Choy, Kevin Rey, Winnie Enns, Stefan Rose-John
Publikováno v:
American Journal of Physiology-Cell Physiology. 320:C554-C565
IL-6 affects tissue protective/reparative and inflammatory properties of vascular endothelial cells (ECs). This cytokine can signal to cells through classic and trans-signaling mechanisms, which are differentiated based on the expression of IL-6 rece
Publikováno v:
Am J Physiol Cell Physiol
Cystic fibrosis (CF) lung disease persists and remains life-limiting for many patients. Elevated high-mobility group box-1 protein (HMGB-1) levels and epithelial sodium channel hyperactivity (ENaC) are hallmark features of the CF lung. The objective
Autor:
Deng-Fu Guo, Kamal Rahmouni
Publikováno v:
Am J Physiol Cell Physiol
Cell motility and migration play critical roles in various physiological processes and disease states. Here, we show that the BBBsome, a macromolecule composed of eight Bardet-Biedl syndrome (BBS) proteins including BBS1, is a critical determinant of
Autor:
Megan O’Meara, Tomomi Ichinose, Hainan Li, Leo M Hall, Xiang Zhang, Marisa Kujawa, Yihan Wang, Jie-Mei Wang
Publikováno v:
Am J Physiol Cell Physiol
Endothelial dysfunction is a key risk factor in diabetes-related multiorgan damage. Methylglyoxal (MGO), a highly reactive dicarbonyl generated primarily as a by-product of glycolysis, is increased in both type 1 and type 2 diabetic patients. MGO can
Publikováno v:
American Journal of Physiology-Cell Physiology. 314:C545-C553
Vascular basal cyclooxygenase-2 (COX-2) expression and activity can be induced by endotoxin, hypoxia, or ischemia. During vascular pathologies such as atherosclerosis, increases in COX-2 activity result in prostanoid production, a contributor to the
Autor:
Jinglian Yan, Lawrence M. Schwartz, Katherine L. Hayes, Sarah Witkowski, Louis M. Messina, Amy S. Burnside
Publikováno v:
American Journal of Physiology-Cell Physiology. 314:C534-C544
Peripheral artery disease is an atherosclerotic occlusive disease that causes limb ischemia and has few effective noninterventional treatments. Stem cell therapy is promising, but concomitant diabetes may limit its effectiveness. We evaluated the the
Publikováno v:
American Journal of Physiology-Cell Physiology. 314:C554-C568
Studies have demonstrated the therapeutic potential of estrogen metabolite 2-methoxyestradiol (2ME2) in several cardiovascular disorders, including hypertension. However, the exact mechanism(s) remains unknown. In this study, primary rat aortic smoot
Publikováno v:
American Journal of Physiology-Cell Physiology. 308:C164-C175
Among emerging antidiabetic agents, glucagon-like peptide-1 (GLP-1)-based therapies carry special cardiovascular implications, exerting both direct and indirect effects. The control of vascular permeability is of pivotal importance in vascular pathol
Autor:
Nikki L. Jernigan, Juan Ramiro-Diaz, Wieslawa Giermakowska, John Weaver, Laura V. Gonzalez Bosc
Publikováno v:
American Journal of Physiology-Cell Physiology. 307:C928-C938
We recently demonstrated increased superoxide (O2·−) and decreased H2O2 levels in pulmonary arteries of chronic hypoxia-exposed wild-type and normoxic superoxide dismutase 1 (SOD1) knockout mice. We also showed that this reciprocal change in O2·