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Autor:
Nonhlanhla S. Mkumbuzi, Simon M. Jensen, Jesper L. Andersen, Peter Schjerling, Abigail L. Mackey, Michael Kjaer, Cecilie J. L. Bechshøft, Christian Skou Eriksen, Rene B. Svensson
Publikováno v:
American Journal of Physiology-Cell Physiology. 316:C898-C912
The decline in skeletal muscle regenerative capacity with age is partly attributed to muscle stem cell (satellite cell) dysfunction. Recent evidence has pointed to a strong interaction between myoblasts and fibroblasts, but the influence of age on th
Autor:
Ramail Siddiqui, Gracious R Ross, A. Jamil Tajik, Arshad Jahangir, Yang Shi, Alessandra DeFranco, Farhan Rizvi, Alisher Holmuhamedov, Larisa Emelyanova, David C. Kress, Ulugbek Negmadjanov, Ekhson Holmuhamedov
Publikováno v:
American Journal of Physiology-Cell Physiology. 311:C330-C339
Fibroblasts, the most abundant cells in the heart, contribute to cardiac fibrosis, the substrate for the development of arrythmogenesis, and therefore are potential targets for preventing arrhythmic cardiac remodeling. A chamber-specific difference i
Autor:
Mingliang Ye, Guangdong Zhou, Wei Liu, Zhiyong Zhang, Yilin Cao, Wenjie Zhang, Keyun Wang, Jie Li, Hanfa Zou, Wenbo Wang
Publikováno v:
American Journal of Physiology-Cell Physiology. 310:C357-C372
Micropattern topography is widely investigated for its role in mediating stem cell differentiation, but remains unexplored for phenotype switch between mature cell types. This study investigated the potential of inducing tenogenic phenotype in human
Autor:
Ahmed Zarrough, Thomas E. Van Dyke, Anne Isine Bolstad, Alpdogan Kantarci, Henning Lygre, Charles N. Serhan, Kamal Mustafa, Hatice Hasturk, Manal Mustafa
Publikováno v:
American Journal of Physiology-Cell Physiology. 305:C673-C679
Resolution agonists are endogenous mediators that drive inflammation to homeostasis. We earlier demonstrated in vivo activity of resolvins and lipoxins on regenerative periodontal wound healing. The goal of this study was to determine the impact of r
Autor:
Avery L. McIntosh, Barbara P. Atshaves, Joel S. Lwande, Stephen M. Storey, Subramanian Senthivinayagam, Cameron C. Murphy, Kenneth C. Moon, Shipra Gupta
Publikováno v:
American Journal of Physiology-Cell Physiology. 303:C728-C742
Despite increasing awareness of the health risks associated with excess lipid storage in cells and tissues, knowledge of events governing lipid exchange at the surface of lipid droplets remains unclear. To address this issue, fluorescence resonance e
Autor:
Sandra T. Davidge, Xiuhua Wang, Vijay Kandalam, Zamaneh Kassiri, Josef M. Penninger, Gavin Y. Oudit, Subhadeep Chakrabarti, Ahmed Awad
Publikováno v:
American Journal of Physiology-Cell Physiology. 298:C679-C692
Tumor necrosis factor (TNF) is an inflammatory cytokine that is upregulated in a number of cardiomyopathies. Adverse cardiac remodeling and dilation result from degradation of the extracellular matrix by matrix metalloproteinases (MMPs). We investiga
Autor:
Gary E. Shull, Vikram Prasad, Monu Goel, Mark Estacion, Diana L. Kunze, William G. Sinkins, William P. Schilling
Publikováno v:
American Journal of Physiology-Cell Physiology. 297:C1533-C1543
Maitotoxin (MTX) activates Ca2+-permeable nonselective cation channels and causes a dramatic increase in cytosolic free Ca2+concentration ([Ca2+]i) in every cell examined to date, but the molecular identity of the channels involved remains unknown. A
Autor:
Edward M. Schwarz, Xiaochao Wei, Xinping Zhang, Regis J. O'Keefe, Hicham Drissi, Lisa M. Flick
Publikováno v:
American Journal of Physiology-Cell Physiology. 297:C310-C320
In prosthetic loosening, bone resorption is induced by wear debris particles generated from the artificial joint articulation. Our prior work showed that synovial-like fibroblasts respond to titanium particles by producing receptor activator of NF-ka
Autor:
Andrew J. Putnam, Ekaterina Kniazeva
Publikováno v:
American Journal of Physiology-Cell Physiology. 297:C179-C187
Identifying the mechanisms regulating angiogenesis in pathological conditions such as cancer and heart disease is crucial to develop successful therapies. The dependence of angiogenesis on characteristic properties of these conditions, such as altera
Publikováno v:
American Journal of Physiology-Cell Physiology. 295:C468-C474
Pancreatic β-cells are susceptible to oxidative stress, which is related closely to the islet dysfunction. In the present study, using the pancreatic cell lines HIT-T15 and RINm5F as known in vitro models of impaired β-cell function as well as prim