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Autor:
Deng-Fu Guo, Kamal Rahmouni
Publikováno v:
Am J Physiol Cell Physiol
Cell motility and migration play critical roles in various physiological processes and disease states. Here, we show that the BBBsome, a macromolecule composed of eight Bardet-Biedl syndrome (BBS) proteins including BBS1, is a critical determinant of
Autor:
Irina Korichneva, Josiane Arnaud, Emeline Lemarié, Brigitte Gonthier, Jessica Morand, Diane Godin-Ribuot, Anne Briançon-Marjollet
Publikováno v:
American Journal of Physiology-Cell Physiology
American Journal of Physiology-Cell Physiology, American Physiological Society, 2019, 317 (2), pp.C270-C276. ⟨10.1152/ajpcell.00460.2018⟩
American Journal of Physiology-Cell Physiology, 2019, 317 (2), pp.C270-C276. ⟨10.1152/ajpcell.00460.2018⟩
American Journal of Physiology-Cell Physiology, American Physiological Society, 2019, 317 (2), pp.C270-C276. ⟨10.1152/ajpcell.00460.2018⟩
American Journal of Physiology-Cell Physiology, 2019, 317 (2), pp.C270-C276. ⟨10.1152/ajpcell.00460.2018⟩
International audience; Zinc is involved in the expression and function of various transcription factors, including the hypoxia-inducible factor-1 (HIF-1). HIF-1 and its target gene endothelin-1 (ET-1) are activated by intermittent hypoxia (IH), one
Publikováno v:
American Journal of Physiology-Cell Physiology. 314:C404-C414
Zn2+ is an essential element for cell survival/growth, and its deficiency is linked to many disorders. Extracellular Zn2+ concentration changes participate in modulating fundamental cellular processes such as proliferation, secretion, ion transport,
Publikováno v:
American Journal of Physiology-Cell Physiology. 309:C51-C59
The role of the actin cytoskeleton in endothelial barrier function has been debated for nearly four decades. Our previous investigation revealed spontaneous local lamellipodia in confluent endothelial monolayers that appear to increase overlap at int
Autor:
Anna Hindes, Carole J. Burns, Alexi Kiss, Gregory I. Goldberg, Miroslav Blumenberg, Barry L. Marmer, Tatiana Efimova, Aaron C. Koppel
Publikováno v:
American Journal of Physiology-Cell Physiology. 306:C899-C909
Proline-rich protein tyrosine kinase 2 (Pyk2) is a member of the focal adhesion kinase family. We used Pyk2 knockout (Pyk2-KO) mice to study the role of Pyk2 in cutaneous wound repair. We report that the rate of wound closure was delayed in Pyk2-KO c
Publikováno v:
American Journal of Physiology-Cell Physiology. 306:C753-C761
c-Abl is a nonreceptor protein tyrosine kinase that has a role in regulating smooth muscle cell proliferation and contraction. The role of c-Abl in smooth muscle cell migration has not been investigated. In the present study, c-Abl was found in the l
Autor:
Ahmed Zarrough, Thomas E. Van Dyke, Anne Isine Bolstad, Alpdogan Kantarci, Henning Lygre, Charles N. Serhan, Kamal Mustafa, Hatice Hasturk, Manal Mustafa
Publikováno v:
American Journal of Physiology-Cell Physiology. 305:C673-C679
Resolution agonists are endogenous mediators that drive inflammation to homeostasis. We earlier demonstrated in vivo activity of resolvins and lipoxins on regenerative periodontal wound healing. The goal of this study was to determine the impact of r
Autor:
Paul F. Nealey, Joshua T. Morgan, Joshua Z. Gasiorowski, Britta Dreier, Christopher J. Murphy, Paul Russell
Publikováno v:
American Journal of Physiology-Cell Physiology. 305:C290-C298
Vascular endothelial cells in vivo are exposed to multiple biophysical cues provided by the basement membrane, a specialized extracellular matrix through which vascular endothelial cells are attached to the underlying stroma. The importance of biophy
Autor:
Alexandre Marchand, Sophie Nadaud, Nathalie Mougenot, Anne-Marie Lompré, Tiphaine Hery, Johannes Vogt, Odette Poirier, Julien Amour, Jean-Sébastien Saulnier-Blache, Amira Gaaya, Fabrice Atassi, Florent Soubrier
Publikováno v:
American Journal of Physiology-Cell Physiology
American Journal of Physiology-Cell Physiology, 2012, 303 (10), pp.C1104-C1114. ⟨10.1152/ajpcell.00051.2012⟩
American Journal of Physiology-Cell Physiology, 2012, 303 (10), pp.C1104-C1114. ⟨10.1152/ajpcell.00051.2012⟩
International audience; Plasticity-related gene-1 (PRG-1) protects neuronal cells from lysophosphatidic acid (LPA) effects. In vascular smooth muscle cells (VSMCs), LPA was shown to induce phenotypic modulation in vitro and vascular remodeling in viv
Autor:
Yusuke Abe, Tomoko Shizuno, Atsuko Sato, Kimiko Yamamoto, Joji Ando, Takayuki Asahara, Haruchika Masuda, Syotaro Obi
Publikováno v:
American Journal of Physiology-Cell Physiology. 303:C595-C606
Endothelial progenitor cells (EPCs) are mobilized from bone marrow to peripheral blood, and contribute to angiogenesis in tissue. In the process, EPCs are exposed to shear stress generated by blood flow and tissue fluid flow. Our previous study showe