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Autor:
Richard T. Mathias, Nicholas A. Delamere, Sarah Redmon, Mohammad Shahidullah, Amritlal Mandal, David Križaj, Junyuan Gao
Publikováno v:
Am J Physiol Cell Physiol
The porcine lens response to a hyperosmotic stimulus involves an increase in the activity of an ion cotransporter sodium-potassium/two-chloride cotransporter 1 (NKCC1). Recent studies with agonists and antagonists pointed to a mechanism that appears
Autor:
Thomas A. Kwiatkowski, Aubrey L. Rose, Rosalie Yan, Noah Weisleder, Diana Hallak, Ana Capati, Rachel Jung
Publikováno v:
Am J Physiol Cell Physiol
Various previous studies established that the amphiphilic tri-block copolymer known as poloxamer 188 (P188) or Pluronic-F68 can stabilize the plasma membrane following a variety of injuries to multiple mammalian cell types. This characteristic led to
Autor:
Wei P. Feinstein, Silas J. Leavesley, Wenkuan Xin, Cristhiaan D. Ochoa, Bing Zhu, Andrea L. Britain, Wito Richter, Thomas C. Rich
Publikováno v:
American Journal of Physiology-Cell Physiology. 309:C415-C424
Recent studies have demonstrated that functionally discrete pools of phosphodiesterase (PDE) activity regulate distinct cellular functions. While the importance of localized pools of enzyme activity has become apparent, few studies have estimated enz
Publikováno v:
American Journal of Physiology-Cell Physiology. 299:C1203-C1211
We have found that phospholemman (PLM) associates with and modulates the gating of cardiac L-type calcium channels (Wang et al., Biophys J 98: 1149–1159, 2010). The short 17 amino acid extracellular NH2-terminal domain of PLM contains a highly cons
Publikováno v:
American Journal of Physiology-Cell Physiology. 299:C828-C835
Prestin is the motor protein within the lateral membrane of outer hair cells (OHCs), and it is required for mammalian cochlear amplification. Expression of prestin precedes the onset of hearing in mice, and it has been suggested that prestin undergoe
Autor:
Kenji Funabashi, Susumu Ohya, Noriyuki Hatano, Yuji Imaizumi, Katsuhiko Muraki, Hisao Yamamura, Wayne R. Giles
Publikováno v:
American Journal of Physiology-Cell Physiology. 298:C786-C797
In articular cartilage inflammation, histamine release from mast cells is a key event. It can enhance cytokine production and matrix synthesis and also promote cell proliferation by stimulating chondrocytes. In this study, the functional impact of Ca
Autor:
Sung Joon Kim, Hye-Lim Kim, Su Jung Park, Yang-Sook Chun, Jong Wan Park, Si-On Choi, Kyung Sun Park
Publikováno v:
American Journal of Physiology-Cell Physiology. 297:C855-C864
Hypoxic inhibition of K+ current is a critical O2-sensing mechanism. Previously, it was demonstrated that the cooperative action of TASK-1 and NADPH oxidase-4 (NOX4) mediated the O2-sensitive K+ current response. Here we addressed the O2-sensing mech
Publikováno v:
American Journal of Physiology-Cell Physiology. 297:C290-C298
Prestin is a membrane protein expressed in the outer hair cells (OHCs) in the cochlea that is essential for hearing. This unique motor protein transduces a change in membrane potential into a considerable mechanical force, which leads to a cell lengt
Publikováno v:
American Journal of Physiology-Cell Physiology. 294:C820-C832
This study explores the nature of K fluxes in human lens epithelial cells (LECs) in hyposmotic solutions. Total ion fluxes, Na-K pump, Cl-dependent Na-K-2Cl (NKCC), K-Cl (KCC) cotransport, and K channels were determined by 85Rb uptake and cell K (Kc)
SCAM analysis reveals a discrete region of the pore turret that modulates slow inactivation in Kv1.5
Publikováno v:
American Journal of Physiology-Cell Physiology. 292:C1041-C1052
In Kv1.5, protonation of histidine 463 in the S5-P linker (turret) increases the rate of depolarization-induced inactivation and decreases the peak current amplitude. In this study, we examined how amino acid substitutions that altered the physico-ch