Zobrazeno 1 - 10
of 28
pro vyhledávání: ''
Autor:
Ramail Siddiqui, Gracious R Ross, A. Jamil Tajik, Arshad Jahangir, Yang Shi, Alessandra DeFranco, Farhan Rizvi, Alisher Holmuhamedov, Larisa Emelyanova, David C. Kress, Ulugbek Negmadjanov, Ekhson Holmuhamedov
Publikováno v:
American Journal of Physiology-Cell Physiology. 311:C330-C339
Fibroblasts, the most abundant cells in the heart, contribute to cardiac fibrosis, the substrate for the development of arrythmogenesis, and therefore are potential targets for preventing arrhythmic cardiac remodeling. A chamber-specific difference i
Autor:
Rio Jati Kusuma, Christopher Nguyen, Taylor Friemel, Sonia Manca, Sonal Sukreet, Janos Zempleni
Publikováno v:
American Journal of Physiology-Cell Physiology. 310:C800-C807
Encapsulation of microRNAs in exosomes confers protection against degradation and a vehicle for shuttling of microRNAs between cells and tissues, and cellular uptake by endocytosis. Exosomes can be found in foods including milk. Humans absorb cow's m
Publikováno v:
American Journal of Physiology-Cell Physiology. 309:C271-C281
Blood vessels are subjected to numerous biomechanical forces that work harmoniously but, when unbalanced because of vascular smooth muscle cell (vSMC) dysfunction, can trigger a wide range of ailments such as cerebrovascular, peripheral artery, and c
Publikováno v:
American Journal of Physiology-Cell Physiology. 309:C51-C59
The role of the actin cytoskeleton in endothelial barrier function has been debated for nearly four decades. Our previous investigation revealed spontaneous local lamellipodia in confluent endothelial monolayers that appear to increase overlap at int
Publikováno v:
American Journal of Physiology-Cell Physiology. 308:C944-C958
cGMP-dependent protein kinase I (PKGI) is an important effector of cGMP signaling that regulates vascular smooth muscle cell (SMC) phenotype and proliferation. PKGI has been detected in the perinuclear region of cells, and recent data indicate that p
Autor:
Ramaswamy Krishnan, Robert L. Steward, C. Corey Hardin, Jeffrey J. Fredberg, Dhananjay T. Tambe
Publikováno v:
American Journal of Physiology-Cell Physiology. 308:C657-C664
Endothelial cell alignment along the direction of laminar fluid flow is widely understood to be a defining morphological feature of vascular homeostasis. While the role of associated signaling and structural events have been well studied, associated
Autor:
Sumathy Mohan, Zheng Hongying, Ryszard Konopinski, Mohan Natarajan, Samy L. Habib, Manickam Krishnan, Alakesh Bera, Linda J. Roman
Publikováno v:
American Journal of Physiology-Cell Physiology. 308:C673-C683
Endothelial nitric oxide (NO) synthase (eNOS) is the predominant isoform that generates NO in the blood vessels. Many different regulators, including heat shock protein 90 (Hsp90), govern eNOS function. Hsp90-dependent phosphorylation of eNOS is a cr
Autor:
Nikki L. Jernigan, Juan Ramiro-Diaz, Wieslawa Giermakowska, John Weaver, Laura V. Gonzalez Bosc
Publikováno v:
American Journal of Physiology-Cell Physiology. 307:C928-C938
We recently demonstrated increased superoxide (O2·−) and decreased H2O2 levels in pulmonary arteries of chronic hypoxia-exposed wild-type and normoxic superoxide dismutase 1 (SOD1) knockout mice. We also showed that this reciprocal change in O2·
Autor:
Haichun Ma, Rachel K. Bowser, Su Dong, Andrew Khoo, Nathaniel M. Weathington, Lina Zhang, Jianxin Wei, Jing Zhao, Yutong Zhao, Shuqi Xiao
Publikováno v:
American Journal of Physiology-Cell Physiology. 307:C893-C899
E-cadherin is essential for the integrity of adherens junctions between lung epithelial cells, and the loss of E-cadherin allows cell motility and is thought to promote lung cancer metastasis. While the downregulation of E-cadherin expression has bee
Publikováno v:
American Journal of Physiology-Cell Physiology. 307:C878-C892
Microvascular stability and regulation of capillary tonus are regulated by pericytes and their interactions with endothelial cells (EC). While the RhoA/Rho kinase (ROCK) pathway has been implicated in modulation of pericyte contractility, in part via