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pro vyhledávání: ''
Autor:
Keith R. Brunt, Kjetil Ask, Jeremy A. Simpson, Emma J B Holjak, Iryna Savinova, Brittany A. Edgett, Anabelle M Ng, Victoria L. Nelson, Leslie M. Ogilvie, Mathew J. Platt
Publikováno v:
Am J Hypertens
Background The Spontaneously Hypertensive Rat (SHR) Colony was established in 1963 and is the most commonly used rodent model for studying heart failure (HF). Ideally, animal models should recapitulate the clinical disease as closely as possible. Any
Autor:
Rachel T Scarl, Min Xiao, Lee Hebert, Laura Biederman, Sergey V. Brodsky, Iouri Ivanov, Kyle Ware, Anjali A. Satoskar, Vedat O. Yildiz, Jessica Hemminger, Ajay Medipally
Publikováno v:
Am J Hypertens
BACKGROUND Hypertension is a leading cause of chronic kidney disease worldwide. Early studies demonstrated the short-term effects of hypertension on kidney function and morphology in ablative nephropathy. The aim of this study was to investigate the
Autor:
Hong-Li Chi, Tong Xiao, Xiao-Jing Yu, Hong-Li Gao, Abdoulaye Issotina Zibrila, Yu-Ming Kang, Hong-Bao Li, Ying Li, Jie Qi, Yan Zhang, Xiao-Lian Shi, Li-Yan Fu, Yu-Xin Lu, Qing Su, Yan-Mei Chen
Publikováno v:
American Journal of Hypertension. 34:840-850
BACKGROUND N-Methyl-d-aspartate receptor (NMDAR) in the hypothalamic paraventricular nucleus (PVN) plays critical roles in regulating sympathetic outflow. Studies showed that acute application of the antagonists of NMDAR or its subunits would reduce
Autor:
Lilach O. Lerman, Xiangyang Zhu, Lei Zhang, Amir Lerman, Alfonso Eirin, Mohamed C. Farah, Arash Aghajani Nargesi, Ishran M. Saadiq, Hui Tang, Kyra L. Jordan
Publikováno v:
Am J Hypertens
BACKGROUND Renovascular hypertension (RVH) often manifest with metabolic syndrome (MetS) as well. Coexisting MetS and hypertension increases cardiovascular morbidity and mortality, but the mechanisms underlying cardiac injury remain unknown. We hypot
Publikováno v:
Am J Hypertens
Background Previous studies suggest that obesity-induced hypertension in females, but not males, is due to leptin-mediated stimulation of aldosterone secretion and subsequent activation of the mineralocorticoid receptor (MR). Although angiotensin II
Identification of Clock Genes Related to Hypertension in Kidney From Spontaneously Hypertensive Rats
Autor:
Takahiro Ueno, Yoshiaki Matsumoto, Noboru Fukuda, Yoshinobu Fuke, Yusuke Murata, Hiroki Kobayashi, Seiichiro Hemmi, Sho Tanaka, Masahiro Okamura, Masanori Abe
Publikováno v:
American Journal of Hypertension
Background There is a diurnal variation in the blood pressure fluctuation of hypertension, and blood pressure fluctuation abnormality is considered to be an independent risk factor for organ damage including cardiovascular complications. In the curre
Publikováno v:
American Journal of Hypertension. 33:1127-1135
BACKGROUND Hyperhomocysteinemia (HHcy) plays a synergistic role with hypertension in vascular injury; however, the relationship between HHcy and hypertension in renal injury remains unclear. Here, we sought to evaluate the relationship between HHcy a
Publikováno v:
American Journal of Hypertension
The protein chemerin (tazarotene-induced gene, TIG2; RARRES2) is a relatively new adipokine. Many studies support that circulating chemerin levels associate strongly and positively with body mass index, visceral fat, and blood pressure. Here, we focu
Autor:
Bernardo Rodriguez-Iturbe, Takahiko Nakagawa, Eric E. Kelley, Federica Piani, Magdalena Madero, Claudio Borghi, Gabriel Cara-Fuentes, Laura G. Sánchez-Lozada, Richard J. Johnson, Daniel I. Feig, Petter Bjornstad, Miguel A. Lanaspa
Publikováno v:
American Journal of Hypertension. 33:583-594
The association between increased serum urate and hypertension has been a subject of intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones, and possibly vascular calcification. Mendelian randomization studies
Autor:
Alfonso Eirin, Kyra L. Jordan, Arash Aghajani Nargesi, Lilach O. Lerman, Xiangyang Zhu, Amir Lerman, Ishran M. Saadiq
Publikováno v:
Am J Hypertens
BACKGROUND Mitochondria modulate endothelial cell (EC) function, but may be damaged during renal disease. We hypothesized that the ischemic and metabolic constituents of swine renovascular disease (RVD) induce mitochondrial damage and impair the func