Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Peter Heutink"'
Autor:
Ashutosh Dhingra, Joana R. Loureiro, Patrizia Rizzu, Vítor Tedim Cruz, Angela Timóteo, Claudia L. Oliveira, Guy A. Rouleau, Jorge Sequeiros, Andrés Ordóñez-Ugalde, José Bessa, Beatriz Quintáns, María Jesús Sobrido, Cristina Costa, Hugo Marcelino, Ana I. Seixas, Eva Brandão, Angel Carracedo, Paula Coutinho, Peter Heutink, Isabel Silveira, José Leal Loureiro
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The American journal of human genetics 101(1), 87-103 (2017). doi:10.1016/j.ajhg.2017.06.007
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The American journal of human genetics 101(1), 87-103 (2017). doi:10.1016/j.ajhg.2017.06.007
Advances in human genetics in recent years have largely been driven by next-generation sequencing (NGS); however, the discovery of disease-related gene mutations has been biased toward the exome because the large and very repetitive regions that char
Autor:
Matthijs Verhage, Esther S. Lips, Gonçalo R. Abecasis, Arthur P.H. de Jong, George Davey Smith, Danielle Posthuma, Beate Glaser, Dina Ruano, L. Niels Cornelisse, August B. Smit, Peter Heutink, David M. Evans, N J Timpson
Publikováno v:
American Journal of Human Genetics
American Journal of Human Genetics, 86(2), 113-125. Cell Press
American journal of human genetics, 86(2), 113-125. Cell Press
Ruano, D, Abecasis, G R, Glaser, B, Lips, E S, Cornelisse, L N, de Jong, A P H, Evans, D M, Smith, D G, Thimpson, N J, Smit, A B, Heutink, P, Verhage, M & Posthuma, D 2010, ' Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability ', American journal of human genetics, vol. 86, no. 2, pp. 113-125 . https://doi.org/10.1016/j.ajhg.2009.12.006
Ruano, D, Abecasis, G R, Glaser, B, Lips, E S, Cornelisse, L N, de Jong, A P H, Evans, D M, Smith, D G, Thimpson, N J, Smit, A B, Heutink, P, Verhage, M & Posthuma, D 2010, ' Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability ', American Journal of Human Genetics, vol. 86, no. 2, pp. 113-125 . https://doi.org/10.1016/j.ajhg.2009.12.006
American Journal of Human Genetics, 86(2), 113-125. Cell Press
American journal of human genetics, 86(2), 113-125. Cell Press
Ruano, D, Abecasis, G R, Glaser, B, Lips, E S, Cornelisse, L N, de Jong, A P H, Evans, D M, Smith, D G, Thimpson, N J, Smit, A B, Heutink, P, Verhage, M & Posthuma, D 2010, ' Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability ', American journal of human genetics, vol. 86, no. 2, pp. 113-125 . https://doi.org/10.1016/j.ajhg.2009.12.006
Ruano, D, Abecasis, G R, Glaser, B, Lips, E S, Cornelisse, L N, de Jong, A P H, Evans, D M, Smith, D G, Thimpson, N J, Smit, A B, Heutink, P, Verhage, M & Posthuma, D 2010, ' Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability ', American Journal of Human Genetics, vol. 86, no. 2, pp. 113-125 . https://doi.org/10.1016/j.ajhg.2009.12.006
Although cognitive ability is a highly heritable complex trait, only a few genes have been identified, explaining relatively low proportions of the observed trait variation. This implies that hundreds of genes of small effect may be of importance for
Autor:
Nancy J. Cox, Harvey S. Singer, Cathy L. Barr, Susan L. Santangelo, Jean-Baptiste Rivière, Peter Heutink, William M. McMahon, Dianne Keen-Kim, G. Gericke, S. E. Stewart, John T. Walkup, Nelson B. Freimer, Cornelia Illmann, Roger Kurlan, Christine Bétard, Peter Como, Mary M. Robertson, Francois Richer, James F. Leckman, David L. Pauls, J.R. Kidd, Paul Lespérance, Mark Leppert, Kenneth K. Kidd, Ben A. Oostra, Robert A. King, Hilary Coon, D. L. Pauls, Sylvain Chouinard, Annemieke J.M.H. Verkerk, A.J. Pakstis, Donna Palumbo, D. Zelenika, Danielle C. Cath, Jeremiah M. Scharf, Chiara Sabatti, Jill Platko, Paul Sandor, Carol A. Mathews, Marco A. Grados, Yves Dion, Guy A. Rouleau
Publikováno v:
American Journal of Human Genetics, 80(2), 265-272. Cell Press
Tourette disorder (TD) is a neuropsychiatric disorder with a complex mode of inheritance and is characterized by multiple waxing and waning motor and phonic tics. This article reports the results of the largest genetic linkage study yet undertaken fo
Publikováno v:
CIÊNCIAVITAE
Europe PubMed Central
Europe PubMed Central
For a linkage study it is important to ascertain family material that is sufficiently informative. The statistical power of a linkage sample can be determined via computer simulation. For complex traits uncertain parameters such as incomplete penetra