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Autor:
Al B. Benson, Hong Li, Heinz-Josef Lenz, Daniel G. Haller, Carlos Robles, Rachel E. Sanborn, Motomi Mori, Charles D. Blanke, Nora Mattek, Tomislav Dragovich, Emerson Y. Chen, Charles D. Lopez
Publikováno v:
American Journal of Clinical Oncology. 41:1193-1198
Colorectal cancer (CRC) is the second leading cause of cancer death in the United States. Cyclooxygenase-2 (COX-2) overexpression is associated with increased tumor invasiveness and proliferation in CRC, and COX-2 inhibition has demonstrated chemopre
Autor:
Tomoya Kawaguchi, Kazuto Hirata, Tatsuo Kimura, Naoki Yoshimoto, Shinzoh Kudoh, Shigeki Mitsuoka, Naruo Yoshimura, Tomohiro Tamiya, Kenji Sawa, Takuhito Tada, Yoshiya Matsumoto, Tomohiro Suzumura, Masako Hosono, Tomonori Hirashima, Hidenori Tanaka
Publikováno v:
American Journal of Clinical Oncology. 41:967-971
A phase I study to determine a recommended dose of thoracic radiotherapy using accelerated hyperfractionation for unresectable non-small cell lung cancer was conducted.We used chemotherapy of a cisplatin doublet and 2 dose levels of radiation with ac
Autor:
Shinya Kajiura, Hiroshi Mihara, Ayumu Hosokawa, Akira Yoshioka, Naoki Horikawa, Haruka Fujinami, Yuka Kobayashi, Hiroki Yoshita, Toshiro Sugiyama, Akira Ueda, Hideki Origasa, Takayuki Ando, Kazuhisa Yabushita, Kohei Ogawa
Publikováno v:
American Journal of Clinical Oncology. 41:977-981
Objectives To investigate the usefulness of S-1 plus cisplatin alternating with S-1 plus docetaxel as first-line treatment in patients with advanced gastric cancer, we conducted a phase I/II study to determine the maximum tolerated dose and recommend
Autor:
Steven I. Robinson, Peter S. Rose, Carola A.S. Arndt, Randolph S. Marks, Candace L. Haddox, Scott H. Okuno, Karen J. Fritchie, Evanthia Galanis, Jonas Paludo
Publikováno v:
American Journal of Clinical Oncology. 41:832-837
OBJECTIVES: Extraskeletal osteosarcoma (EO) is a malignant neoplasm that produces osteoid, bone, and chondroid material without direct attachment to bone or periosteum. Surgical resection is the mainstay of treatment; the role of chemotherapy is not
Autor:
Benhua Xu, Guoxian Guan, Yuyan Guo, Yinghong Yang, Debao Zhou, Qing Duan, Zhicao Yue, Yuangui Chen, Pan Chi, Chi Lin
Publikováno v:
American Journal of Clinical Oncology. 41:601-606
Objectives To evaluate pretreatment tumor thickness in predicting pathologic complete response (pCR) of stage II/III rectal adenocarcinoma to neoadjuvant chemoradiation (chemoradiotherapy [CRT]). Methods We retrospectively analyzed 185 patients who w
Autor:
Judith Hurley, Tadeu Ambros, Victoria Sujoy, Kunal Saigal, Jean L. Wright, Ali M. Saeed, Cristiane Takita, Isildinha M. Reis, Wei Zhao
Publikováno v:
American Journal of Clinical Oncology. 40:490-497
Purpose: We report clinical outcomes in patients treated with neoadjuvant endocrine therapy (NET) versus neoadjuvant cytotoxic chemotherapy (NCT) in a cohort of postmenopausal women with ER+, HER2− breast cancer. Materials and Methods: We retrospec
Autor:
Oliviero Ostellino, Giovanni Succo, Elisa Bellini, Fulvia Pedani, Giuseppe Riva, Nertila Naqe, Giancarlo Pecorari, Matteo Sensini, Mario Airoldi, Luca Raimondo, Massimiliano Garzaro
Publikováno v:
American Journal of Clinical Oncology. 40:86-90
Recurrent or metastatic salivary gland malignancies (RMSGM) are not suitable for conventional treatment. We report the clinical outcomes of 60 patients affected by RMSGM who were treated with DDP+VNB as a first-line or second-line scheme.Sixty patien
Autor:
Mark A. Socinski, Alan Sandler, Joan H. Schiller, Larry Leon, Suresh S. Ramalingam, Jyoti D. Patel, Corey J. Langer, Sebastien Hazard
Publikováno v:
American Journal of Clinical Oncology
Supplemental Digital Content is available in the text.
Background: Patient-level data from 2 phase III studies in patients with previously untreated, advanced-stage, nonsquamous non–small cell lung cancer (NSCLC) were pooled to examine outcome
Background: Patient-level data from 2 phase III studies in patients with previously untreated, advanced-stage, nonsquamous non–small cell lung cancer (NSCLC) were pooled to examine outcome
Phase II Trial of Target-guided Personalized Chemotherapy in First-line Metastatic Colorectal Cancer
Autor:
Manuel Hidalgo, Emilio Vicente, Jesus Rodriguez-Pascual, Antonio Cubillo, Ovidio Hernando, Yolanda Quijano, Carlos Plaza, Fernando López-Ríos, Elena García, Rafael Álvarez, Carmen Rubio, Sofia Perea, Gema Sanchez
Publikováno v:
American Journal of Clinical Oncology. 39:236-242
The aim of this study was to investigate the feasibility and efficacy of personalizing treatment of patients with advanced untreated colorectal cancer (CRC).Patients with untreated metastatic CRC, performance status 0-1, and candidates for systemic c
Autor:
David Miller, Dustin B. Manders, April A. Bailey, Lindsay Hwang, Kevin Albuquerque, Jayanthi S. Lea, Siobhan M. Kehoe, Debra L. Richardson, Travis T. Sims
Publikováno v:
American journal of clinical oncology. 41(12)
Cervical cancer metastatic to the para-aortic lymph nodes (PALNs) carries a poor prognosis. Despite extended-field radiation therapy (EFRT), only 30% to 50% of patients will survive 3 years. We sought to examine the treatment regimens used, associate