Zobrazeno 1 - 10
of 537
pro vyhledávání: ''
Autor:
Ailsa Hart, James L. Alexander, Lucy C. Hicks, Horace R T Williams, Julian Marchesi, Kate Gallagher, Jia V. Li, Nick Powell, Benjamin H. Mullish, Shiva T. Radhakrishnan
Publikováno v:
Alimentary Pharmacology & Therapeutics. 55:26-48
Background The gut microbiota has been implicated in the pathogenesis of inflammatory bowel disease (IBD), with Faecalibacterium prausnitizii associated with protection, and certain genera (including Shigella and Escherichia) associated with adverse
Autor:
Ben Kang, Jaeyoung Choi, Soo-Youn Lee, Yon Ho Choe, Rihwa Choi, Soohyun Ahn, Tae Jun Kim, Sun-Young Baek
Publikováno v:
Alimentary Pharmacology & Therapeutics. 52:459-470
BACKGROUND The association between NUDT15 polymorphisms and thiopurine-induced leucopenia is well known. AIM To investigate the association between NUDT15 polymorphisms and time-to-leucopenia in paediatric patients with inflammatory bowel disease (IB
Autor:
Christoph Schramm, Christian Casar, Ansgar W. Lohse, Wolfgang Lieb, Gerald Denk, Corinna Bang, Marcial Sebode, Malte Christoph Ruehlemann, Timur Liwinski, Andre Franke, Simon Hohenester
Publikováno v:
Alimentary Pharmacology & Therapeutics. 51:1417-1428
BACKGROUND The pathogenesis of autoimmune hepatitis (AIH) is poorly understood and little is known about enteric microbiota in AIH. AIM To investigate disease-specific microbiome alterations in AIH. METHODS The V1-V2 variable regions of the 16S rRNA
Autor:
I Gastin, Thomas Remen, Sébastien Daude, Laurent Peyrin-Biroulet, Silvio Danese, Thomas Chateau, Cédric Baumann, Jean-Louis Guéant
Publikováno v:
Alimentary Pharmacology & Therapeutics. 51:1087-1095
The diagnosis of iron deficiency is based on ferritin and transferrin saturation (TfS) in inflammatory bowel disease (IBD) patients, yet guideline thresholds are not evidence-based. Soluble transferrin receptor (sTfR) is one of the best noninvasive t
Publikováno v:
Alimentary Pharmacology & Therapeutics. 51:356-363
BACKGROUND Anti-drug antibodies (ADAs) are a leading contributor to infliximab loss of response and adverse drug events. It is not feasible to identify patients at risk of antibody formation before initiating infliximab. The genetic variation HLADQA1
Autor:
Siddharth Sood, Ricky Lim, Geoffrey W. McCaughan, Wendy Cheng, Miriam T. Levy, Alan Wigg, William Sievert, Katherine A. Stuart, Simone I. Strasser, Gerry MacQuillan, Paul J Gow, Amanda Nicoll, Jonathan Mitchell, Edmund Tse, Stuart K. Roberts, Richard Skoien, Martin Weltman, Amany Zekry, Joanne Mitchell, Jacob George
Publikováno v:
Alimentary Pharmacology & Therapeutics. 49:1314-1322
BACKGROUND Mycophenolate mofetil is a commonly used salvage therapy for patients with autoimmune hepatitis (AIH). AIM To evaluate the predictors of response to mycophenolate rescue therapy to facilitate clinical decision making. METHODS We performed
Autor:
Amanda Nicoll, David Moore, Francesco Amico, Adam Doyle, Brad Hockey, Siddharth Sood, Bridget Bishop, Dolores B. Njoku, Alexandra Gorelik, Nicholas Hannah, Danny Liew
Publikováno v:
Alimentary Pharmacology & Therapeutics. 49:940-951
Background Volatile anaesthetics are known to cause drug-induced liver injury, a hepatotoxic reaction characterised by antibodies to trifluoroacetylated lipid and protein adducts and cytochrome p450 2E1. The incidence of volatile anaesthetic drug-ind
Autor:
Patrizia Zentilin, Elisabetta Giuliana, Maria Giulia Demarzo, Giorgia Bodini, Edoardo G. Giannini
Publikováno v:
Alimentary Pharmacology & Therapeutics. 54:536-537
Publikováno v:
Alimentary Pharmacology & Therapeutics.
BACKGROUND: Intestinal bacteria produce metabolites and by-products necessary for homeostasis. Imbalance in this equilibrium is linked to multiple pathologies including inflammatory bowel disease (IBD). The role of the gut microbiota in determining t
Publikováno v:
Alimentary Pharmacology & Therapeutics.
Background A critical aspect of liver transplantation in hepatitis B patients is to prevent graft reinfection with hepatitis B virus. The use of hepatitis B immune globulin after transplant was a significant milestone, which allowed prolonged graft a