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Autor:
Neville D. Yeomans, Nicholas J. Talley, A. B. R. Thomson, Christopher J. Hawkey, Angel Lanas, Jorgen Naesdal, John Hart
Publikováno v:
Alimentary Pharmacology & Therapeutics. 31:143-149
Summary Background Gastroduodenal ulcers are common in patients taking low-dose aspirin. However, the factors predisposing to mucosal erosions, the precursor lesions, are not well known. Aims To examine the potential risk factors for the development
Publikováno v:
Alimentary Pharmacology & Therapeutics. 26:869-878
Summary Background Chromogranin has been proposed as a marker for gastrin-dependent enterochromaffin-like cell proliferation. Aim To examine this question in three populations: acid hypersecretors with gastrinoma (Zollinger–Ellison), or without gas
Publikováno v:
Alimentary Pharmacology & Therapeutics. 7:463-466
Omeprazole heals most duodenal ulcers after 4 weeks of treatment but relapse is common. Eradication of Helicobacter pylori is associated with reduced rate of ulcer relapse. This study investigates the effect of omeprazole with antibiotics in H. pylor
Publikováno v:
Alimentary Pharmacology & Therapeutics. 6:373-380
SUMMARY Pantoprazole selectively blocks gastric parietal cell H+,K+-ATPase. To define a dosage regimen for clinical trials we compared the effect of pantoprazole 40 and 60 mg daily on 24-h intragastric acidity and plasma gastrin concentrations using
Publikováno v:
Alimentary Pharmacology & Therapeutics. 8:181-185
SUMMARY Methods: Forty-three patients positive for Helicobacter pylori by histology and culture of antral biopsies (n = 40) or histology alone (n= 3) were investigated. They received either regimen 1-tripotassium dicitrato bismuthate 120 mg q.d.s. an
Publikováno v:
Alimentary Pharmacology & Therapeutics. 8:603-607
SUMMARY Background: Malabsorption due to exocrine pancreatic insufficiency is the main gastrointestinal problem in cystic fibrosis. Despite high doses of pancreatic enzyme supplements it is often not possible to normalize fat absorption. We compared
Publikováno v:
Alimentary Pharmacology & Therapeutics. 7:443-449
Sixty patients with symptomatic duodenal ulcer were randomized to receive either omeprazole (20 mg each morning) or famotidine (40 mg at night time) for 2-4 weeks in a double-blind parallel group clinical trial. Healing rates were higher with omepraz
Publikováno v:
Alimentary Pharmacology & Therapeutics. 8:417-424
SUMMARY Background: Patients on nonsteroidal antiinflammatory drugs can develop curious intestinal fibrotic diaphragms. Methods: Groups of rats received indomethacin mixed into a powdered diet at 3 mg.kg/day for 6 and 12 weeks and 6 mg. kg/day for up
Autor:
M. D. Gershon
Publikováno v:
Alimentary Pharmacology & Therapeutics. 20:3-14
The gut is the only organ that can display reflexes and integrative neuronal activity even when isolated from the central nervous system. This activity can be triggered by luminal stimuli that are detected by nerves via epithelial intermediation. Epi
Autor:
Hicham Gharib, L. Stanescu, Bruno Bonaz, R. Bost, S. Bruley des Varannes, Valerie Bicheler, S. Bonnot-Marlier, J. C. Delchier
Publikováno v:
Alimentary Pharmacology & Therapeutics. 20:899-907
Summary Background : The treatment of acid-related symptoms requires rapid and consistent acid suppression, especially with on-demand regimens. Aim : To compare the antisecretory activity of low-dose rabeprazole and omeprazole in healthy, Helicobacte