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pro vyhledávání: '"Morris, D."'
Publikováno v:
Alcoholism: Clinical and Experimental Research. 22:1212-1219
Diethyldithiocarbamate methyl ester (DDTC-Me) is a precursorto the formation of S-methyl-N,N-diethylthiolcarbamate sulfoxide, the active metabolite proposed to be responsible for the alcohol deterrent effects of disulfiram. The present study investig
Autor:
Morris D. Faiman, Bruce W. Hart
Publikováno v:
Alcoholism: Clinical and Experimental Research. 18:340-345
S-methyl N,N-diethylthiolcarbamate sulfoxide (DETC-MeSO) is proposed to be the metabolite of disulfiram responsible for the in vivo inhibition of liver low Km, aldehyde dehydrogenase (ALDH) in the rat. Studies were conducted in male Sprague-Dawley ra
Autor:
J. Chris Jensen, Morris D. Faiman
Publikováno v:
Alcoholism: Clinical and Experimental Research. 10:45-49
Studies were carried out to determine whether the disuifiram-ethanol reaction (DER) in the rat could be correlated with blood acetaldehyde, ethanol, and liver aldehyde dehydrogenase (ALOH) inhibition. Both hypothermia and hypotension were used as ind