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Publikováno v:
Alcohol Clin Exp Res
BACKGROUND AND PURPOSE: Binge drinking is a serious problem among adolescents and young adults despite its adverse consequences on the brain and behavior. One area that remains poorly understood concerns the impact of chronic intermittent ethanol (CI
Autor:
David F. Werner, Jonathan K. Gore-Langton, Elena I. Varlinskaya, Justine D. Landin, Linda P. Spear
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND: Adolescent alcohol abuse can lead to behavioral dysfunction and chronic, relapsing alcohol use disorder (AUD) in adulthood. However, not all adolescents that consume alcohol will develop an AUD, therefore it is critical to identify neural
Autor:
Tara Teppen, Kelsey M. Miller, Subhash C. Pandey, Hannah G. Sexton, Patrick J. Mulholland, H. Scott Swartzwelder
Publikováno v:
Alcoholism, clinical and experimental research. 42(4)
Background Adolescent intermittent ethanol (AIE) exposure produces persistent impairments in cholinergic and epigenetic signaling and alters markers of synapses in the hippocampal formation, effects that are thought to drive hippocampal dysfunction i
Autor:
Hongwei Liu, Seungwoo Kang, Jing Li, Danielle Gregor, Rao Fu, Wanhong Zuo, Jiang-Hong Ye, Alex Bekker, Rose Paulose, Caihong Fu, Pei Chen
Publikováno v:
Alcoholism, clinical and experimental research. 41(3)
Background Hyperalgesia or increased sensitivity to pain is often found in alcoholics during alcohol withdrawal and may contribute to relapse drinking. Alternative therapies such as acupuncture and electroacupuncture (EA), through mechanisms involvin
Autor:
Sraboni Sarkar, Sulie L. Chang
Publikováno v:
Alcoholism, Clinical and Experimental Research
Background Binge drinking of high ethanol (EtOH) concentration beverages is common among young adults and can be a risk factor for exposure to sexually transmitted diseases, including HIV-1. We used a novel noninfectious HIV-1 transgenic (HIV-1Tg) ra
Autor:
Muhammad Farooq, Annie M. Whitaker, Christy A. Itoga, M. Adrienne McGinn, Nicholas W. Gilpin, Kimberly N. Edwards, Rod I. Paulsen, Jonathan E. Reppel, Scott Edwards
Publikováno v:
Alcoholism, clinical and experimental research. 40(12)
Background Nicotine use increases alcohol drinking, suggesting that the combination of these drugs may produce synergistic effects in activating reward circuitry. Alternatively, use of either of these drugs may facilitate the development of cross-tol
Publikováno v:
Alcoholism, Clinical and Experimental Research
Background Dopaminergic (DAergic) neurons of the ventral tegmental area (VTA) are important for the rewarding and reinforcing properties of alcohol and other drugs of abuse. Regulation of the firing of DAergic VTA neurons is controlled by a number of
Publikováno v:
Alcoholism, clinical and experimental research. 40(12)
Background The objective of this study was to characterize the acute pharmacological effects of ethanol (EtOH) on extracellular dopamine in the dorsomedial and dorsolateral striata. This is the first study to quantify and directly compare the effects
Publikováno v:
Alcoholism, clinical and experimental research. 40(2)
Background The aim of this study was to examine possible differences in nicotinic acetylcholine receptors and responses in rats with genetic preference or avoidance for alcohol. This was done by using 2 rat lines with high alcohol preference (Alko Al
Publikováno v:
Alcoholism, clinical and experimental research. 40(3)
Background The aversive properties of ethanol (EtOH) that limit its intake are poorly understood. There is an increasing interest in the role of the rostromedial tegmental nucleus (RMTg), because it encodes aversion signals and inhibits motivated beh