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Autor:
David F. Werner, Jonathan K. Gore-Langton, Elena I. Varlinskaya, Justine D. Landin, Linda P. Spear
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND: Adolescent alcohol abuse can lead to behavioral dysfunction and chronic, relapsing alcohol use disorder (AUD) in adulthood. However, not all adolescents that consume alcohol will develop an AUD, therefore it is critical to identify neural
Publikováno v:
Alcoholism, clinical and experimental research. 39(12)
Background Alcohol-mediated neurodegeneration is associated with white matter (WM) atrophy due to targeting of myelin and oligodendrocytes. However, variability in disease severity suggests cofactors contribute to WM degeneration. We examined the pot
Publikováno v:
Alcoholism, clinical and experimental research. 38(8)
Background Methylphenidate (MPH) is a stimulant prescribed to treat attention-deficit/ hyperactivity disorder. Its primary mechanism of action is in the dopamine system, alterations of which are associated with vulnerability to alcohol abuse. There a
Autor:
Javier Fernández-Solari, Juan C. Elverdin, Pablo Nicolás Surkin, Cesar A. Ossola, Claudia E. Mohn
Publikováno v:
Alcoholism, clinical and experimental research. 38(7)
Background: The aim of this study was to assess the effects of chronic alcohol consumption on periodontitis development in rats. Methods: Periodontal disease was experimentally induced by lipopolysaccharide (LPS; 2 mg/ml) injections into the gingival
Autor:
João Paulo de Arruda Amorim, Leonardo O. Mendes, Beatriz A.F. Fontanelli, Francisco Eduardo Martinez, Luiz Gustavo de Almeida Chuffa, Antonio Rugolo Júnior, Marcelo Martinez, Otávio Augusto Martins, Giovana Rampazzo Teixeira, Wagner José Fávaro, Sergio Luiz Pereira, Patricia Fernanda Felipe Pinheiro, Wílson de Mello Júnior, Cilmery Suemi Kurokawa
Publikováno v:
Alcoholism, clinical and experimental research. 37(1)
Background Ethanol (EtOH) alters the all-trans-retinoic acid (ATRA) levels in some tissues. Retinol and ATRA are essential for cell proliferation, differentiation, and maintenance of prostate homeostasis. It has been suggested that disturbances in re
Publikováno v:
Alcoholism, clinical and experimental research. 36(9)
Background Hepatosteatosis is an essential step in liver disease progression. However, the mechanisms that mediate the progression of hepatosteatosis and the optimal inhibitor of them remain largely unclear. The sympathetic nervous system (SNS) is re
Autor:
Jinyao Liu, Tatsuya Fujimiya
Publikováno v:
Alcoholism, clinical and experimental research. 34
Background: Pathologists examining victims of sudden unexpected death encounter alcoholics more often than expected; alcohol may play a role in sudden arrhythmic death. Here we determine whether a pattern of alcohol consumption, chronic ethanol intak
Autor:
Alexandra Kowalski, Justin M. Farook, Tracy D. Stepanyan, John M. Littleton, Susan Barron, Eva Kaplan
Publikováno v:
Alcoholism, clinical and experimental research. 32(12)
Background: The ethanol withdrawal (EWD) syndrome is typically treated using benzodiazepines such as diazepam. However there is concern that benzodiazepines may not prevent neurotoxicity associated with EWD. Antagonists of glutamate/N-Methyl-D-Aspart
Publikováno v:
Alcoholism, clinical and experimental research. 31(4)
BACKGROUND Alcohol abuse, both chronic and acute, is a known modulator of immune function and is associated with increased incidence of traumatic injury. Previously, we demonstrated that acute alcohol intoxication before hemorrhagic shock impairs hem
Autor:
Kenichi Ikejima, Tsuneo Kitamura, Yoshiyuki Takei, Nobuhiro Sato, Shunhei Yamashima, Nobuyuki Enomoto
Publikováno v:
Alcoholism, clinical and experimental research. 29
Background: Activation of Kupffer cells by lipopolysaccharide (LPS) plays a pivotal role in the onset of pathophysiological events that occur during endotoxemia and intracellular calcium ([Ca 2+ ] i ) is involved in LPS-stimulated cytokine production