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Autor:
Ricardo Schneider, Vanessa Schuck Clarimundo, Carla Dalmaz, Carolina Ferreira Santos, Elaine Elisabetsky, Rosane Gomez
Publikováno v:
Alcohol (Fayetteville, N.Y.). 49(3)
N-acetylcysteine (NAC), a glutamate-modulating agent with antioxidant and anti-inflammatory properties, has been considered as a potential anti-addictive drug. Beneficial effects were reported for cocaine, cannabis, and tobacco addicts, but the effec
Autor:
Leslie L. Devaud
Publikováno v:
Alcohol (Fayetteville, N.Y.). 29(2)
The current investigation was undertaken to explore further the interactions between ethanol and the phencyclidine analog dizocilpine maleate (MK-801) on behaviors in male and female rats. It was previously found that ethanol dependence conferred cro
Autor:
Christopher J. LaBuda, Perry N. Fuchs
Publikováno v:
Alcohol (Fayetteville, N.Y.). 26(1)
Neurochemical investigations of the anti-anxiety action of ethanol demonstrate that increased dopaminergic, noradrenergic, and serotonergic activity mediates the anxiolytic actions of ethanol. Results of studies with animals and human beings also con
Publikováno v:
Alcohol (Fayetteville, N.Y.). 18(2-3)
Results of our previous research in rats demonstrate the following: (a) Angiotensin II (Ang II) inhibits long term potentiation (LTP) in dentate granule cell-perforant path synapses and that this inhibition can be blocked by losartan, an Ang II AT1 r
Autor:
Bo Söderpalm, Mia Ericson, Annelie Petersson, Peter Olausson, Alexander Kosowski, Jörgen A. Engel
Publikováno v:
Alcohol (Fayetteville, N.Y.). 15(1)
This study evaluated the influence of nefazodone, a combined 5-HT 2A receptor antagonist and 5-HT reuptake inhibitor, on the behavioral and neurochemical effects of ethanol in nonselected male Wistar rats. In microdialysis experiments, ethanol (2.5 g
Publikováno v:
Alcohol (Fayetteville, N.Y.). 14(3)
Ethanol is metabolized in the brain by catalase/H2O2 to yield acetaldehyde and by an ethanol-inducible form of cytochrome P450 (P450 IIE1) in a reaction that yields oxygen radicals. Within the cytoplasm of serotonergic axon terminals these metabolic
Publikováno v:
Alcohol (Fayetteville, N.Y.). 11(5)
The alcohol-sensitive ANT and the alcohol-insensitive AT rat lines developed by selective breeding for differential sensitivity to motor impairment on the tilting plane by a moderate ethanol dose (2 g/kg, IP), were cross-bred to produce second genera
Publikováno v:
Alcohol (Fayetteville, N.Y.). 10(1)
Prenatal alcohol exposure is associated with a variety of developmental abnormalities, including neuroanatomical, physical, and behavioral features. Several mechanisms for alcohol's teratogenic effects have been proposed. This study addresses the rol
Publikováno v:
Alcohol (Fayetteville, N.Y.). 6(5)
Four groups of five rats each received training on the Geller-Seifter procedure and then received 0.5, 1.0 or 2.0 mg/kg diazepam (DZ) or vehicle, respectively, 15 min prior to the behavior sessions for 14 days. On Day 14 of DZ treatment rats also wer
Autor:
Charles H.M. Beck, Elliot A. Loh
Publikováno v:
Alcohol (Fayetteville, N.Y.). 6(4)
The hypothesis that chronic treatment with diazepam or with ethanol reduces behavioral variability, was tested on rats in a radial maze. Eight groups (n = 6) of male Sprague-Dawley rats were given one of eight treatments of diazepam (0.0, 1.5, 3.0 or