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Publikováno v:
Advances in biological regulation. 67
Oocyte activation is a fundamental event at mammalian fertilisation, initiated by a series of characteristic calcium (Ca2+) oscillations in mammals. This characteristic pattern of Ca2+ release is induced in a species-specific manner by a sperm-specif
Autor:
Jordane Biarc, Hubert Hondermarck, Ralph A. Bradshaw, Jay Pundavela, Robert J. Chalkley, Alma L. Burlingame
Publikováno v:
Advances in Biological Regulation. 58:16-27
Nerve growth factor (NGF) and its precursor (proNGF) are primarily considered as regulators of neuronal function that induce their responses via the tyrosine kinase receptor TrkA and the pan-neurotrophin receptor p75NTR. It has been generally held th
Publikováno v:
Advances in Biological Regulation. 57:112-119
Defects in pancreatic β-cell function and survival are key components in type 2 diabetes (T2D). An age-dependent deterioration in β-cell function has also been observed, but little is known about the molecular mechanisms behind this phenomenon. Our
Publikováno v:
Advances in Biological Regulation. 53:156-163
Over the last two decades we have focused on beta cell signal transduction, bringing many new insights, especially in the context of insulin signal transduction, the role of inositol polyphosphates and the regulation of cytoplasmic free Ca(2+) concen