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Autor:
Deborah Pushparajah, Salma Jimenez, Shirley Wong, Hibah Alattas, Roderick A. Slavcev, Nafiseh Nafissi
Publikováno v:
Advanced Drug Delivery Reviews
The novel betacoronavirus, SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has spread across the globe at an unprecedented rate since its first emergence in Wuhan City, China in December 2019. Scientific communities around the world hav
Publikováno v:
Advanced Drug Delivery Reviews
With the COVID-19 pandemic now ongoing for close to a year, people all over the world are still waiting for a vaccine to become available. The initial focus of accelerated global research and development efforts to bring a vaccine to market as soon a
Publikováno v:
Advanced Drug Delivery Reviews
Due to the high prevalence and long incubation periods often without symptoms, the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected millions of individuals globally, causing the coronavirus disease 2019 (COVID-19) pandemic. E
Autor:
Anthony J. Hickey
Publikováno v:
Advanced Drug Delivery Reviews
Ideally, inhaled therapy is driven by the needs of specific disease management. Lung biology interfaces with inhaler performance to allow optimal delivery of therapeutic agent for disease treatment. Inhalation aerosol products consist of the therapeu
Autor:
Bernard Lebleu, Michael J. Gait, Prisca Boisguerin, Sébastien Deshayes, Liz O'Donovan, Matthew J.A. Wood, Caroline Godfrey, Corinne A. Betts
Publikováno v:
Advanced Drug Delivery Reviews
Advanced Drug Delivery Reviews, Elsevier, 2015, 87, pp.52--67. ⟨10.1016/j.addr.2015.02.008⟩
Advanced Drug Delivery Reviews, Elsevier, 2015, 87, pp.52--67. ⟨10.1016/j.addr.2015.02.008⟩
Oligonucleotide-based drugs have received considerable attention for their capacity to modulate gene expression very specifically and as a consequence they have found applications in the treatment of many human acquired or genetic diseases. Clinical
Autor:
Michael D. Buschmann, Abderrazzak Merzouki, Marc Thibault, Myriam Jean, Vincent Darras, Marc Lavertu
Publikováno v:
Advanced Drug Delivery Reviews
Alternatives to efficient viral vectors in gene therapy are desired because of their poor safety profiles. Chitosan is a promising non-viral nucleotide delivery vector because of its biocompatibility, biodegradability, low immunogenicity and ease of
Publikováno v:
Advanced Drug Delivery Reviews
Respiratory gene therapy has been considered for the treatment of a broad range of pulmonary disorders. However, respiratory secretions form an important barrier towards the pulmonary delivery of therapeutic nucleic acids. In this review we will star
Autor:
Masanori Ikeda, Nobuyuki Kato
Publikováno v:
Advanced Drug Delivery Reviews
The therapy for chronic hepatitis C (CH-C) started with interferon (IFN) monotherapy in the early 1990s and this therapy was considered effective in about 10% of cases. The present standard therapy of pegylated IFN with ribavirin achieves a sustained
Autor:
Rebecca L. Wilson, Dennis E. Hruby
Publikováno v:
Advanced Drug Delivery Reviews
Following the anthrax attacks of 2001 and the recent SARS outbreak, concerns about emerging and re-emerging infectious diseases have catalyzed a renewed interest in developing new vaccination strategies that provide rapid and flexible response option