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Autor:
Jin-ping Pang, Xue-ping Hu, Yun-xia Wang, Jia-ning Liao, Xin Chai, Xu-wen Wang, Chao Shen, Jia-jia Wang, Lu-lu Zhang, Xin-yue Wang, Feng Zhu, Qin-jie Weng, Lei Xu, Ting-jun Hou, Dan Li
Publikováno v:
Acta Pharmacologica Sinica
Synthetic glucocorticoids (GCs) have been widely used in the treatment of a broad range of inflammatory diseases, but their clinic use is limited by undesired side effects such as metabolic disorders, osteoporosis, skin and muscle atrophies, mood dis
Publikováno v:
Acta Pharmacologica Sinica
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought an unprecedented public health crisis and persistently threatens to humanity. With tireless efforts from scientists around the wo
Publikováno v:
Acta Pharmacologica Sinica
The spike protein of SARS-CoV-2 interacts with angiotensin-converting enzyme 2 (ACE2) of human respiratory epithelial cells, which leads to infection. Furthermore, low-dose radiation has been found to reduce inflammation and aid the curing of COVID-1
Autor:
Shuang-Qu Li, Xi Cheng, Yi Wang, Zhaobing Gao, Xu-Rui Shen, Yan Wu, Sui Fang, Weijuan Shang, Bingqing Xia, Jian-Rong Xu, Leike Zhang
Publikováno v:
Acta Pharmacologica Sinica
Lack of efficiency has been a major problem shared by all currently developed anti-SARS-CoV-2 therapies. Our previous study shows that SARS-CoV-2 structural envelope (2-E) protein forms a type of cation channel, and heterogeneously expression of 2-E
Autor:
Zhen-chuan Wang, Shi-peng Liang, Lei Wang, Xuanzhong Wang, Pengfei Ge, Guangfan Chi, Chuan He, Chongcheng Wang, Tianfei Luo, Chun-sheng Feng, Shan Lu, Chen Li
Publikováno v:
Acta Pharmacologica Sinica
Ferroptotic cell death is characterized by iron-dependent lipid peroxidation that is initiated by ferrous iron and H2O2 via Fenton reaction, in which the role of activating transcription factor 3 (ATF3) remains elusive. Brucine is a weak alkaline ind
Autor:
Xuanzhong Wang, Meihua Piao, Zhen-chuan Wang, Tianfei Luo, Shi-peng Liang, Guangfan Chi, Shan Lu, Lei Wang, Chongcheng Wang, Pengfei Ge, Chuan He
Publikováno v:
Acta Pharmacologica Sinica
FOXO3a (forkhead box transcription factor 3a) is involved in regulating multiple biological processes in cancer cells. BNIP3 (Bcl-2/adenovirus E1B 19-kDa-interacting protein 3) is a receptor accounting for priming damaged mitochondria for autophagic
Autor:
Dao Wen Wang, Hong Wang, Chen ze Li, Fei Ma, Rui Li, He song Zeng, Ali J. Marian, Guanglin Cui, Li yuan Peng
Publikováno v:
Acta Pharmacologica Sinica
COVID-19 is a multiorgan systemic inflammatory disease caused by SARS-CoV-2 virus. Patients with COVID-19 often exhibit cardiac dysfunction and myocardial injury, but imaging evidence is lacking. In the study we detected and evaluated the severity of
Publikováno v:
Acta Pharmacologica Sinica
The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest current threat to global public health. The highly infectious SARS-CoV-2 virus primarily attac
Autor:
Jiantao Ye, Xiaolei Zhang, Dayue D Duan, Peiqing Liu, Chun-xiang Zhang, Jing Lu, Zhuoming Li, Lingyu Linda Ye
Publikováno v:
Acta Pharmacologica Sinica
The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chloroquine phosphate and its derivative hyd
Publikováno v:
Acta Pharmacologica Sinica
Cerebral edema is a pathological hallmark of various central nervous system (CNS) insults, including traumatic brain injury (TBI) and excitotoxic injury such as stroke. Due to the rigidity of the skull, edema-induced increase of intracranial fluid si