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Autor:
Ronald J. Quinn, Mingming Xu, Hai-Yan Zhang, Philip Ryan, George D. Mellick, Santosh Rudrawar
Publikováno v:
Acta Pharmacologica Sinica
Abnormal protein aggregation has been linked to many neurodegenerative diseases, including Parkinson’s disease (PD). The main pathological hallmark of PD is the formation of Lewy bodies (LBs) and Lewy neurites, both of which contain the presynaptic
Autor:
Kunkun Han, Zubin Zhang, Ying Ren, Gautam Sethi, Biyin Cao, Xiaowen Tang, Chen-yu Mao, Xin Xu, Yujia Xu, Xinliang Mao
Publikováno v:
Acta Pharmacologica Sinica
RNF6, a RING-type ubiquitin ligase, has been identified as an oncogene in various cancers but its role in multiple myeloma (MM) remains elusive. In the present study we first showed that the expression levels of RNF6 in MM were significantly elevated
Publikováno v:
Acta Pharmacologica Sinica
Although thrombelastography (TEG) has been widely implemented in the clinical setting of endovascular intervention, consensus on the optimal parameter for defining high ischemic risk patients is lacking due to the limited data about the relationship
Publikováno v:
Acta Pharmacologica Sinica
Epigallocatechin gallate (EGCG), a major polyphenol in green tea, exhibits diverse biological activities. Previous studies show that EGCG could effectively suppress HBV gene expression and replication, but the role of EGCG in HBV replication and its
Autor:
Chuanke Zhao, Changhao Liu, Zhen Cheng, Teli Liu, Hua Zhu, Hong Zhang, Jing Wang, Zhen-fu Li, Zhi Yang, Jing Shen, Bin Dong
Publikováno v:
Acta Pharmacologica Sinica
Monoclonal antibodies are believed to be magic bullets and hold great potential for lots of biological process. About 100 μg of mAb109 was expressed in 5 × 106 cells after 10 days’ immunization. 64Cu-NOTA-mAb109 was synthesized with the specific
Autor:
Chunyu Zeng, He Wang, Zhengfan Gong, Hongmei Ren, Lian-pan Wu, Chao Liu, Jian Yang, Yu Han, Ming-ming Zhang, Zhou Zhongshu
Publikováno v:
Acta Pharmacologica Sinica
Abnormal growth of the intimal layer of blood vessels (neointima formation) contributes to the progression of atherosclerosis and in-stent restenosis. Recent evidence shows that the 18-kDa translocator protein (TSPO), a mitochondrial membrane protein
Autor:
Hai Zou, Sheng qing Li
Publikováno v:
Acta Pharmacologica Sinica
Publikováno v:
Acta Pharmacologica Sinica
The clinical performance of conventional cancer therapy approaches (surgery, radiotherapy, and chemotherapy) has been challenged by tumor metastasis and recurrence that is mainly responsible for cancer-caused mortalities. The cancer immunotherapy is
Autor:
Hua Xie, Jian Ding, Linjiang Tong, Peiran Song, Meng-zhen Lai, Tao Zhang, Dou Dou, Honglin Li, Yanyan Diao
Publikováno v:
Acta Pharmacologica Sinica
Bruton’s tyrosine kinase (BTK) is a key component of the B cell receptor (BCR) signaling pathway and plays a crucial role in B cell malignancies and autoimmune disorders; thus, it is an attractive target for the treatment of B cell related diseases
Autor:
Yuan Xie, Guoyu Pan, Li Han, Xiaoying Liao, Zhitao Wu, Jiye Aa, Qiangqiang Deng, Guangji Wang, Zhao-liang Peng
Publikováno v:
Acta Pharmacologica Sinica
Rheumatoid arthritis patients can be prescribed a combination of immunosuppressive drug leflunomide (LEF) and the antiviral drug acyclovir to reduce the high risk of infection. Acyclovir is a substrate of organic anion transporter (OAT) 1/3 and multi