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Publikováno v:
Acta Pharmacologica Sinica
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought an unprecedented public health crisis and persistently threatens to humanity. With tireless efforts from scientists around the wo
Publikováno v:
Acta Pharmacologica Sinica
The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest current threat to global public health. The highly infectious SARS-CoV-2 virus primarily attac
Autor:
Jiantao Ye, Xiaolei Zhang, Dayue D Duan, Peiqing Liu, Chun-xiang Zhang, Jing Lu, Zhuoming Li, Lingyu Linda Ye
Publikováno v:
Acta Pharmacologica Sinica
The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chloroquine phosphate and its derivative hyd
Publikováno v:
Acta Pharmacologica Sinica
Cerebral edema is a pathological hallmark of various central nervous system (CNS) insults, including traumatic brain injury (TBI) and excitotoxic injury such as stroke. Due to the rigidity of the skull, edema-induced increase of intracranial fluid si
Publikováno v:
Acta Pharmacologica Sinica
Cancer immunotherapy has received extensive attention due to its ability to activate the innate or adaptive immune systems of patients to combat tumors. Despite a few clinical successes, further endeavors are still needed to tackle unresolved issues,
Publikováno v:
Acta Pharmacologica Sinica
Current cancer immunotherapy has limited response rates in a large variety of solid tumors partly due to the low immunogenicity of the tumor cells and the immunosuppressive tumor microenvironment (ITM). A number of clinical cancer treatment modalitie
Autor:
Changliang Liu
Publikováno v:
Acta Pharmacologica Sinica
Motor control in the striatum is an orchestra played by various neuronal populations. Loss of harmony due to dopamine deficiency is considered the primary pathological cause of the symptoms of Parkinson's disease (PD). Recent progress in experimental
Publikováno v:
Acta Pharmacologica Sinica
The endocannabinoid system (ECS) has received extensive attention for its neuroprotective effect on the brain. This system comprises endocannabinoids, endocannabinoid receptors, and the corresponding ligands and proteins. The molecular players involv
Autor:
John L. Waddington
Publikováno v:
Acta Pharmacologica Sinica
Following the formulation of operational criteria for the diagnosis of psychosis in Parkinson's disease, a neurodegenerative disorder, the past decade has seen increasing interest in such nonmotor psychopathology that appears to be independent of dop
Autor:
Ronald J. Quinn, Mingming Xu, Hai-Yan Zhang, Philip Ryan, George D. Mellick, Santosh Rudrawar
Publikováno v:
Acta Pharmacologica Sinica
Abnormal protein aggregation has been linked to many neurodegenerative diseases, including Parkinson’s disease (PD). The main pathological hallmark of PD is the formation of Lewy bodies (LBs) and Lewy neurites, both of which contain the presynaptic