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Publikováno v:
Acta Pharmacologica Sinica
The pandemic of coronavirus disease 2019 (COVID-19) and its pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the greatest current threat to global public health. The highly infectious SARS-CoV-2 virus primarily attac
Autor:
Jiantao Ye, Xiaolei Zhang, Dayue D Duan, Peiqing Liu, Chun-xiang Zhang, Jing Lu, Zhuoming Li, Lingyu Linda Ye
Publikováno v:
Acta Pharmacologica Sinica
The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) and an ongoing severe pandemic. Curative drugs specific for COVID-19 are currently lacking. Chloroquine phosphate and its derivative hyd
Publikováno v:
Acta Pharmacologica Sinica
Cerebral edema is a pathological hallmark of various central nervous system (CNS) insults, including traumatic brain injury (TBI) and excitotoxic injury such as stroke. Due to the rigidity of the skull, edema-induced increase of intracranial fluid si
Autor:
Xuelian Zheng, Min Su, Lin Zhang, Yong Lin, Bin Zhou, Zhiping Li, Qin Li, Jiao-Jiao Yang, Yaping Song, Jinke Li, Yanyun Wang
Publikováno v:
Acta Pharmacologica Sinica
Receptor-interacting protein 1 (RIP1, also known as RIPK1) is not only a tumor-promoting factor in several cancers but also mediates either apoptosis or necroptosis in certain circumstances. In this study we investigated what role RIP1 plays in human
Autor:
Changliang Liu
Publikováno v:
Acta Pharmacologica Sinica
Motor control in the striatum is an orchestra played by various neuronal populations. Loss of harmony due to dopamine deficiency is considered the primary pathological cause of the symptoms of Parkinson's disease (PD). Recent progress in experimental
Publikováno v:
Acta Pharmacologica Sinica
The endocannabinoid system (ECS) has received extensive attention for its neuroprotective effect on the brain. This system comprises endocannabinoids, endocannabinoid receptors, and the corresponding ligands and proteins. The molecular players involv
Autor:
John L. Waddington
Publikováno v:
Acta Pharmacologica Sinica
Following the formulation of operational criteria for the diagnosis of psychosis in Parkinson's disease, a neurodegenerative disorder, the past decade has seen increasing interest in such nonmotor psychopathology that appears to be independent of dop
Autor:
Yucheng Wang, Juxian Wang, Rong-Guang Shao, Na Zhang, Hongwei He, Shuang-shuang Zhao, Yi-xuan Zhang
Publikováno v:
Acta Pharmacologica Sinica
Chronic tissue injury with fibrosis results in the disruption of tissue architecture, organ dysfunction, and eventual organ failure. Therefore, the development of effective antifibrotic drugs is urgently required. IMB-S7 is novel biphenyl compound de
Publikováno v:
Acta Pharmacologica Sinica
An increasing number of drugs are metabolized by aldehyde oxidase (AOX), but AOX-mediated drug interactions are seldom reported due to the lack of appropriate inhibitors and inducers. A recent study reported that nimesulide (NIM) could increase the l
Autor:
Yu Bian, Xin Li, Ping Pang, Xue-ling Hu, Shu-ting Yu, Yi-ning Liu, Ning Wang, Jin-hui Wang, Wei Xiao, Wei-jie Du, Bao-feng Yang
Publikováno v:
Acta Pharmacologica Sinica
Pyroptosis is a form of inflammatory cell death that could be driven by the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation following myocardial infarction (MI). Emerging eviden