Zobrazeno 1 - 10
of 10
pro vyhledávání: ''
Autor:
Xiujuan Zhang, Xiaomin Wei, Cheng-wei Li, Shengqing Li, Ning Zhu, Yuanyuan Zhang, Liang Dong, Jingwen Xia, Youzhi Zhang, Gulinuer Wumaier, Peng Zhang
Publikováno v:
Acta Pharmacologica Sinica
Endothelial–mesenchymal transition (EnMT) plays a pivotal role in various diseases, including pulmonary hypertension (PH), and transcription factors like Snail are key regulators of EnMT. In this study we investigated how these factors were regulat
Autor:
Yucheng Wang, Juxian Wang, Rong-Guang Shao, Na Zhang, Hongwei He, Shuang-shuang Zhao, Yi-xuan Zhang
Publikováno v:
Acta Pharmacologica Sinica
Chronic tissue injury with fibrosis results in the disruption of tissue architecture, organ dysfunction, and eventual organ failure. Therefore, the development of effective antifibrotic drugs is urgently required. IMB-S7 is novel biphenyl compound de
Publikováno v:
Acta Pharmacologica Sinica
Fecal microbiota transplantation (FMT) has become an effective strategy to treat metabolic diseases, including type 2 diabetes mellitus (T2DM). We previously reported that the intestinal microbiome had significant difference between individuals with
Autor:
Jing-yu Chen, Wei Wei, Xiao-yu Cai, Qingtong Wang, Jin-ling Shu, Xian-zheng Zhang, Yan Chang, Ling-ling Zhang, Yue Zhu, Xiao-yu Tang, Yu-jing Wu, Le Han, Chen Wang, Hua-xun Wu
Publikováno v:
Acta Pharmacologica Sinica
IgD-Fc-Ig fusion protein, a new biological agent, is constructed by linking a segment of human IgD-Fc with a segment of human IgG1-Fc, which specifically blocks the IgD-IgDR pathway and selectively inhibits the abnormal proliferation, activation, and
Autor:
Guo Songxin, Yihong Wan, Xingang Yao, Min Zou, Xiao-yun Wu, Kutty Selva Nandakumar, Xiaodong Tang, Xiaoguang Chen, Shuwen Liu, Shijun He, Wenyu Wu, Lin Li
Publikováno v:
Acta Pharmacologica Sinica
Dengue fever is an acute infectious disease caused by dengue virus (DENV) and transmitted by Aedes mosquitoes. There is no effective vaccine or antiviral drug available to date to prevent or treat dengue disease. Recently, RNA-dependent RNA polymeras
Autor:
Kunkun Han, Zubin Zhang, Ying Ren, Gautam Sethi, Biyin Cao, Xiaowen Tang, Chen-yu Mao, Xin Xu, Yujia Xu, Xinliang Mao
Publikováno v:
Acta Pharmacologica Sinica
RNF6, a RING-type ubiquitin ligase, has been identified as an oncogene in various cancers but its role in multiple myeloma (MM) remains elusive. In the present study we first showed that the expression levels of RNF6 in MM were significantly elevated
Autor:
Chunyu Zeng, He Wang, Zhengfan Gong, Hongmei Ren, Lian-pan Wu, Chao Liu, Jian Yang, Yu Han, Ming-ming Zhang, Zhou Zhongshu
Publikováno v:
Acta Pharmacologica Sinica
Abnormal growth of the intimal layer of blood vessels (neointima formation) contributes to the progression of atherosclerosis and in-stent restenosis. Recent evidence shows that the 18-kDa translocator protein (TSPO), a mitochondrial membrane protein
Autor:
Hua Xie, Jian Ding, Linjiang Tong, Peiran Song, Meng-zhen Lai, Tao Zhang, Dou Dou, Honglin Li, Yanyan Diao
Publikováno v:
Acta Pharmacologica Sinica
Bruton’s tyrosine kinase (BTK) is a key component of the B cell receptor (BCR) signaling pathway and plays a crucial role in B cell malignancies and autoimmune disorders; thus, it is an attractive target for the treatment of B cell related diseases
Autor:
Yuan Xie, Guoyu Pan, Li Han, Xiaoying Liao, Zhitao Wu, Jiye Aa, Qiangqiang Deng, Guangji Wang, Zhao-liang Peng
Publikováno v:
Acta Pharmacologica Sinica
Rheumatoid arthritis patients can be prescribed a combination of immunosuppressive drug leflunomide (LEF) and the antiviral drug acyclovir to reduce the high risk of infection. Acyclovir is a substrate of organic anion transporter (OAT) 1/3 and multi
Autor:
Yue Xu, Jianhua Ran, Shun Zhang, Runtao Li, Min Li, Bowen Li, Baoxue Yang, Yan Zhao, Shuyuan Wang
Publikováno v:
Acta Pharmacologica Sinica
Urea transporters (UTs) are transmembrane proteins selectively permeable to urea and play an important role in urine concentration. UT-knockout mice exhibit the urea-selective urine-concentrating defect, without affecting electrolyte balance, suggest