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Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3857-3868 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3857-3868 (2021)
Drug-induced liver injury (DILI) is a leading reason for preclinical safety attrition and post-market drug withdrawals. Drug-induced mitochondrial toxicity has been shown to play an essential role in various forms of DILI, especially in idiosyncratic
Autor:
Mei Tian, Baolong Jin, Lingli Chen, Huang Luqi, Ma Rui, Biwei Yin, Jinfu Tang, Liuying Mao, Tong Chen, Haiyan Zhang, Guanghong Cui, Juan Guo, Chang-Jiang-Sheng Lai
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3310-3321 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3310-3321 (2021)
Aconitum carmichaelii is a high-value medicinal herb widely used across China, Japan, and other Asian countries. Aconitine-type diterpene alkaloids (DAs) are the characteristic compounds in Aconitum. Although six transcriptomes, based on short-read n
Autor:
Antonietta Rossi, Tran Hung, Oliver Werz, Christina Weinigel, Rossella Bilancia, Birgit Waltenberger, Zhigang Rao, Veronika Temml, Hermann Stuppner, Christian Kretzer, Carsten Giesel, Andreas Koeberle, Stefan Schwaiger, Silke Rummler, Alilou Mostafa, Tran Thi Van Anh, Paul M. Jordan, Simona Pace
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1629-1647 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1629-1647 (2021)
Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction. Lipid mediators orchestrate both the initiation and resolution of inflammation. Switching from pro-inflammatory to pro-resolv
Autor:
Shijun Zhang, Zhuomao Mo, Wen Ma, Ling Yu, Zhenjie Wang, Binhua Zou, Rui Sun, Yuanyuan Yang, Zhiqiang Yu, Meng Yu
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 2004-2015 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 2004-2015 (2021)
Hepatocellular carcinoma (HCC) has been known as the second common leading cancer worldwide, as it responds poorly to both chemotherapy and medication. Triptolide (TP), a diterpenoid triepoxide, is a promising treatment agent for its effective antica
Autor:
Yandan Ren, Jianying Zhang, Yu Zhao, Yi Hu, Ang Jia, Li Yang, Wuduo Zhao, Guiqin Hou, Zhaoming Lu, Bin Yu, Wen Zhao
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1246-1260 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1246-1260 (2021)
Sulforaphane (SFN), a natural anti-tumor compound from cruciferous vegetables, has been reported to induce protective autophagy to cancer cells, which might impair the anti-tumor efficiency of SFN. However, the accurate function and mechanism of SFN
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1200-1212 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 5, Pp 1200-1212 (2021)
Metabolic syndrome is a clustering of metabolic disorder with unclear molecular mechanism. Increasing studies have found that the pathogenesis and progression of metabolic syndrome are closely related to inflammation. Here, we report celastrol, a tra
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1434-1445 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1434-1445 (2021)
Nature has endowed gaseous molecules such as O2, CO2, CO, NO, H2S, and N2 with critical and diverse roles in sustaining life, from supplying energy needed to power life and building blocks for life's physical structure to mediating and coordinating c
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 835-847 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 835-847 (2021)
Localized delivery, comparing to systemic drug administration, offers a unique alternative to enhance efficacy, lower dosage, and minimize systemic tissue toxicity by releasing therapeutics locally and specifically to the site of interests. Herein, a
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 632-650 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 632-650 (2021)
S-adenosylmethionine (SAM) is ubiquitous in living organisms and is of great significance in metabolism as a cofactor of various enzymes. Methyltransferases (MTases), a major group of SAM-dependent enzymes, catalyze methyl transfer from SAM to C, O,
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 823-834 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 823-834 (2021)
The combination of chemotherapy and photodynamic therapy provides a promising approach for enhanced tumor eradication by overcoming the limitations of each individual therapeutic modality. However, tumor is pathologically featured with extreme hypoxi