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Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 937-951 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 937-951 (2019)
Artemisinin and its derivatives (ARTs) were reported to display heme-dependent antitumor activity. On the other hand, histone deacetylase inhibitors (HDACi) were known to be able to promote heme synthesis in erythroid cells. Nevertheless, the effect
Autor:
Shengbing Yang, Hanjun Li, Jingtian Mei, Han Qiao, Feng Zhou, Minqi Wang, Linyang Chu, Tingting Tang, Xiuguo Han
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 973-985 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 5, Pp 973-985 (2019)
The objective was to investigate the effect of kinsenoside (Kin) treatments on macrophage polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis (OA) progression. RAW264.7 macrophages were polarized to M1/M2 subtyp
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 135-143 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 135-143 (2019)
Obesity is a worldwide epidemic. Promoting browning of white adipose tissue (WAT) contributes to increased energy expenditure and hence counteracts obesity. Here we show that cordycepin (Cpn), a natural derivative of adenosine, increases energy expen
Autor:
Qiaomei Jin, Nan Yao, Zhiqi Yin, Dejian Huang, Dong Jian Zhang, Wei Liu, Fei Peng, Xin Shan, Jian Zhang, Qi Luo, Yuan-Yu Zhao
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 8, Iss 3, Pp 390-400 (2018)
Acta Pharmaceutica Sinica B, Vol 8, Iss 3, Pp 390-400 (2018)
Necrosis is a form of cell death, which is related to various serious diseases such as cardiovascular disease, cancer, and neurodegeneration. Necrosis-avid agents (NAAs) selectively accumulated in the necrotic tissues can be used for imaging and/or t
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 7, Iss 3, Pp 381-389 (2017)
Acta Pharmaceutica Sinica B, Vol 7, Iss 3, Pp 381-389 (2017)
The 5-HT1A receptor agonist 8-hydroxy-2-[di-n-propylamino] tetralin (8-OH-DPAT) promotes ejaculation of male rats, whereas dapoxetine delays this process. However, the gene expression profile of the brain at ejaculation following administrationof the
Autor:
Yang Lv, Guanhua Du, Shou-Bao Wang, Lianhua Fang, Yu Yan, Huifang Zhang, Yi-huang Lin, Yangyang He, Yucai Chen
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 7, Iss 2, Pp 159-166 (2017)
Acta Pharmaceutica Sinica B, Vol 7, Iss 2, Pp 159-166 (2017)
The purpose of this study was to investigate the effects of salvianolic acid A (SAA) in systemic lupus erythematosus (SLE) induced by pristane in BALB/c mice. Lupus mice were established by confirming elevated levels of autoantibodies and IL-6 after
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 6, Iss 4, Pp 329-335 (2016)
Acta Pharmaceutica Sinica B, Vol 6, Iss 4, Pp 329-335 (2016)
A phospholipid-based injectable gel was developed for the sustained delivery of leuprolide acetate (LA). The gel system was prepared using biocompatible materials (SPME), including soya phosphatidyl choline (SPC), medium chain triglyceride (MCT) and
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