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Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 835-847 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 835-847 (2021)
Localized delivery, comparing to systemic drug administration, offers a unique alternative to enhance efficacy, lower dosage, and minimize systemic tissue toxicity by releasing therapeutics locally and specifically to the site of interests. Herein, a
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 632-650 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 632-650 (2021)
S-adenosylmethionine (SAM) is ubiquitous in living organisms and is of great significance in metabolism as a cofactor of various enzymes. Methyltransferases (MTases), a major group of SAM-dependent enzymes, catalyze methyl transfer from SAM to C, O,
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 823-834 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 823-834 (2021)
The combination of chemotherapy and photodynamic therapy provides a promising approach for enhanced tumor eradication by overcoming the limitations of each individual therapeutic modality. However, tumor is pathologically featured with extreme hypoxi
Autor:
Guo-Dong Chen, Dan Hu, Xiao-Long Tang, Weiyang Zhang, Qiao-Zhen Wang, Xin-Sheng Yao, Ping Dai, Kui Hong, Hao Gao, Chuan-Xi Wang
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 588-597 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 588-597 (2021)
Organic carbonates (OCs) are a class of compounds featured by a carbonyl flanked by two alkoxy/aryloxy groups. They exist in either linear or cyclic forms, of which the majority encountered in nature adopt a pentacyclic structure. However, the enzyma
Autor:
Yong Zhou, Jiwen Zhang, Ruxandra Gref, Kena Zhao, Xue Li, Ting Xiong, Li Wu, Caifen Wang, Priyanka Mittal, Tao Guo, Senlin Shi
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 9, Pp 1709-1718 (2020)
Acta Pharmaceutica Sinica B
Acta Pharmaceutica Sinica B, Elsevier, 2020, 10 (9), pp.1709-1718. ⟨10.1016/j.apsb.2020.04.015⟩
Acta Pharmaceutica Sinica B, Vol 10, Iss 9, Pp 1709-1718 (2020)
Acta Pharmaceutica Sinica B
Acta Pharmaceutica Sinica B, Elsevier, 2020, 10 (9), pp.1709-1718. ⟨10.1016/j.apsb.2020.04.015⟩
It is essential to develop new carriers for laryngeal drug delivery in light of the lack of therapy in laryngeal related diseases. When the inhalable micron-sized crystals of γ-cyclodextrin metal-organic framework (CD-MOF) was utilized as dry powder
Autor:
Sirui Zhang, Chen Zhang, Zhe Li, Deyan Wu, Lei Guo, Yinuo Wu, Yi-You Huang, Hao Wang, Hai-Bin Luo, Yang Yuncong, Yuqi Gao, Qian Zhou
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2339-2347 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 12, Pp 2339-2347 (2020)
Optimization efforts were devoted to discover novel PDE10A inhibitors in order to improve solubility and pharmacokinetics properties for a long-term therapy against pulmonary arterial hypertension (PAH) starting from the previously synthesized inhibi
Autor:
Si-Fan Luo, Hai-Yan Tian, Caimin Sheng, Chufang Li, Zhengjin Jiang, Ling Chen, Yumei Zhao, Linbo Guo
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 1846-1855 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 10, Pp 1846-1855 (2020)
Neuraminidase inhibitors (NAIs) are the mainstay antiviral drugs against influenza infection. In this study, a ligand fishing protocol was developed to screen NAIs using neuraminidase immobilized magnetic beads (NA-MB). After verifying the feasibilit
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 5, Pp 789-798 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 5, Pp 789-798 (2020)
The limited treatment options for the increasing occurrence of Lassa hemorrhagic fever in West Africa poses an urgent need for the discovery and development of novel therapeutics. Dietary supplements, especially natural products that are edible and s
Autor:
Chuanzhu Lv, Ling Huang
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 33-41 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 33-41 (2020)
Sepsis is an infection-induced systemic inflammatory syndrome. The immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory pathways. When sepsis occurs, the expression and activity of many inflammato
Targeted delivery of hyaluronic acid nanomicelles to hepatic stellate cells in hepatic fibrosis rats
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 693-710 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 4, Pp 693-710 (2020)
Hepatic fibrosis is one kind of liver diseases with a high mortality rate and incidence. The activation and proliferation of hepatic stellate cells (HSCs) is the most fundamental reason of hepatic fibrosis. There are no specific and effective drug de