Zobrazeno 1 - 10
of 26
pro vyhledávání: ''
Autor:
Sven Hammerschmidt, Karl H. Plate, Roland Nau, Kavi Devraj, Daniel Spitzer, Sylvaine Guérit, Jadranka Macas, Stefan Günther, Maryam I Khel, Camelia M. Monoranu, Michel Mittelbronn, Anne K. Braczynski, Roxana Heidemann, Omolara O. Ogunshola, Gayatri Devraj, Jana Seele, Volkhard A. J. Kempf, Uwe Ködel, Wibke Ballhorn
Publikováno v:
Acta Neuropathologica
Bacterial meningitis is a deadly disease most commonly caused by Streptococcus pneumoniae, leading to severe neurological sequelae including cerebral edema, seizures, stroke, and mortality when untreated. Meningitis is initiated by the transfer of S.
Autor:
Stefan Rutkowski, David W. Ellison, Martin Mynarek, Martin U. Schuhmann, Martin Sill, Christian Thomas, Katja von Hoff, Damian Stichel, Martin Hasselblatt, Andreas von Deimling, Murat Iskar, Peter Lichter, Elke Pfaff, Matthias A. Karajannis, Petra Ketteler, Marc Zapatka, Marcel Kool, Jens Schittenhelm, Dietmar R. Lohmann, Felix Sahm, Marina Rhizova, Anna Kaufhold, Christian Aichmüller, Stefan M. Pfister, Andrey Korshunov, Matija Snuderl, David T.W. Jones, Andrea Wittmann, Brent A. Orr
Publikováno v:
Acta Neuropathol
Tumors of the pineal region comprise several different entities with distinct clinical and histopathological features. Whereas some entities predominantly affect adults, pineoblastoma (PB) constitutes a highly aggressive malignancy of childhood with
Autor:
Felix Sahm, Andreas von Deimling, Takahiro Ono, Damian Stichel, Sebastian Brandner, Wolfgang Wick, Daniel Schrimpf, Manfred Westphal, David Capper, David E. Reuss, Michael Weller, Stefan M. Pfister, Guido Reifenberger, Christel Herold-Mende, Azadeh Ebrahimi, Mitsuaki Shirahata, Daniel Hänggi
Publikováno v:
Acta Neuropathologica. 136:793-803
EGFR amplification (EGFRamp), the combination of gain of chromosome 7 and loss of chromosome 10 (7+/10-), and TERT promoter mutation (pTERTmut) are alterations frequently observed in adult IDH-wild-type (IDHwt) glioblastoma (GBM). In the absence of e
Autor:
Yasin Mamatjan, Michael D. Taylor, Harshika Jain, Abulizi Maimaitiming, Wioletta Glowacka, Hamza Farooq, Paul Kongkham, Makiko Okura, Kenneth Aldape, Romina Nejad
Publikováno v:
Acta Neuropathologica. 135:617-634
Gliomas demonstrate epigenetic dysregulation exemplified by the Glioma CpG Island Methylator Phenotype (G-CIMP) seen in IDH1 mutant tumors. 5-Hydroxymethylcytosine (5hmC) is implicated in glioma pathogenesis; however, its role in IDH1 mutant gliomas
Autor:
Mohini Singh, Thusyanth Vijayakumar, Maleeha Qazi, Parvez Vora, Igor Jurisica, Kevin R. Brown, Nicole McFarlane, Branavan Manoranjan, Amy Hin Yan Tong, David L. Kaplan, Jason Moffat, David Bakhshinyan, John A. Hassell, Naresh Murty, Jean-Claude Cutz, Sujeivan Mahendram, Manvir Dhillon, Kathrin Durrer, Robin Hallet, Tomas Tokar, Sheila K. Singh, Chitra Venugopal
Publikováno v:
Acta Neuropathologica. 134:923-940
Brain metastases (BM) are the most common brain tumor in adults and are a leading cause of cancer mortality. Metastatic lesions contain subclones derived from their primary lesion, yet their functional characterization is limited by a paucity of prec
Autor:
Jens Schittenhelm, Wolfgang Wick, David E. Reuss, Andreas Unterberg, Andrey Korshunov, Daniel Schrimpf, Andreas von Deimling, Michel Mittelbronn, David Capper, Stefan M. Pfister, David T.W. Jones, Felix Sahm, Michael Platten, Michael Weller, Volker Hovestadt, Christel Herold-Mende, Leonille Schweizer, Christian Koelsche, Benedikt Wiestler
Publikováno v:
Acta Neuropathologica. 129:133-146
Diffuse gliomas are represented in the 2007 WHO classification as astrocytomas, oligoastrocytomas and oligodendrogliomas of grades II and III and glioblastomas WHO grade IV. Molecular data on these tumors have a major impact on prognosis and therapy
Autor:
David Capper, Benedikt Wiestler, Tim Holland-Letz, Michael Platten, Andreas von Deimling, Stefan M. Pfister, Michael Weller, Wolfgang Wick, Andrey Korshunov
Publikováno v:
Acta Neuropathologica. 126:443-451
Mutation/loss of alpha-thalassemia/mental retardation syndrome X-linked (ATRX) expression has been described in anaplastic gliomas. The present study explored the role of ATRX status in the molecular classification of anaplastic gliomas and its impac
Autor:
Véronique Sazdovitch, Virginie Stygelbout, Michèle Authelet, Jean Pierre Brion, Anaïs Chanut, Ekaterina Rogaeva, Marie-Claude Potier, Kunie Ando, Pascale N. Lacor, Valérie Suain, Charles Duyckaerts, Jérémie Lavaur, Robert Dedecker
Publikováno v:
Acta Neuropathologica. 125:861-878
PICALM, a clathrin adaptor protein, plays important roles in clathrin-mediated endocytosis in all cell types. Recently, genome-wide association studies identified single nucleotide polymorphisms in PICALM gene as genetic risk factors for late-onset A
Autor:
Felix Lasitschka, Matthias Preusser, Astrid Jeibmann, Andreas von Deimling, Christian Koelsche, Jens Schittenhelm, David Capper, Adelheid Wöhrer, Genevieve Schindler
Publikováno v:
Acta Neuropathologica. 125:891-900
Ganglioglioma is a rare CNS tumor with a benign biological behavior. Recently, the BRAF V600E mutation was identified in approximately 20 % of gangliogliomas. Here, we analyzed a total of 71 gangliogliomas for BRAF V600E mutational status by VE1 immu
Autor:
Nada Jabado, Djihad Hadjadj, Nesrin Sabha, Marcel Kool, Andrey Korshunov, Adam M. Fontebasso, Jeremy Schwartzentruber, Damien Faury, Gelareh Zadeh, Sidney Croul, Guido Reifenberger, Jacek Majewski, Steffen Albrecht, Peter M. Siegel, Noha Gerges, Xiaoyang Liu, Adam Fleming, Zhifeng Dong, David T.W. Jones, Martje Tönjes, Dong-Anh Khuong-Quang, Stefan M. Pfister
Publikováno v:
Acta Neuropathologica. 124:615-625
Gliomas are the most common primary brain tumors in children and adults. We recently identified frequent alterations in chromatin remodelling pathways including recurrent mutations in H3F3A and mutations in ATRX (α-thalassemia/mental-retardation-syn