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Publikováno v:
Acta Neurologica Scandinavica. 96:380-386
Apoptosis has been described as one of the mechanisms of muscle fiber loss in infantile spinal muscular atrophy. In order to investigate if muscle fiber-apoptosis plays a role in other denervating disorders as well, we studied DNA-fragmentation, a ha
Publikováno v:
Acta Neurologica Scandinavica. 116:75-82
The biological role of the scrapie isoform of prion protein (PrP(Sc)) as an infectious agent in numerous human and non-human disorders of the central nervous system is well established. In contrast, and despite decades of intensive research, the phys
Autor:
Robert W. Mahley, Yadong Huang
Publikováno v:
Acta Neurologica Scandinavica. 114:8-14
The unique structural and biophysical features of apolipoprotein (apo) E4 - domain interaction and molten globule formation - have been correlated with the detrimental effects of apoE4 in neuropathology. Two examples of how the structure of apoE4 det