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Publikováno v:
Acta Neurologica Scandinavica. 96:380-386
Apoptosis has been described as one of the mechanisms of muscle fiber loss in infantile spinal muscular atrophy. In order to investigate if muscle fiber-apoptosis plays a role in other denervating disorders as well, we studied DNA-fragmentation, a ha
Autor:
Robert W. Mahley, Yadong Huang
Publikováno v:
Acta Neurologica Scandinavica. 114:8-14
The unique structural and biophysical features of apolipoprotein (apo) E4 - domain interaction and molten globule formation - have been correlated with the detrimental effects of apoE4 in neuropathology. Two examples of how the structure of apoE4 det