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Publikováno v:
Acta Biochimica et Biophysica Sinica
SUMOylation of proteins regulates cell behaviors and is reversibly removed by small ubiquitin-like modifier (SUMO)-specific proteases (SENPs). The SENP family member SENP3 is involved in SUMO2/3 deconjugation and has been reported to sense cell stres
Publikováno v:
Acta Biochimica et Biophysica Sinica. 52:1093-1101
Previously, Nucleolar protein 66 (NO66) was reported to be closely associated with alcohol exposure-induced injury. However, the role of NO66 in alcohol-induced cytotoxicity remains unclear. In this study, we explored the potential effect and mechani
Publikováno v:
Acta Biochimica et Biophysica Sinica. 51:1041-1048
The development of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is a significant advancement in our ability to obtain cardiomyocytes in vitro for regenerative therapies and drug discovery. However, hPSC-CMs obtained via existing prot
Publikováno v:
Acta Biochimica et Biophysica Sinica. 50:1028-1037
Posterior capsule opacification (PCO) results from the proliferation, migration, and epithelial-mesenchymal transition (EMT) of residual lens epithelial cells (LECs) and fibers in the capsular bag. Previous reports have demonstrated that transforming
Publikováno v:
Acta biochimica et biophysica Sinica. 53(10)
Long noncoding RNAs (lncRNAs) have been considered as crucial regulators of acute myocardial infarction (AMI). In this study, to analyze the effect of differentiation antagonizing nonprotein coding RNA (DANCR) of lncRNA on cardiomyocyte damage in AMI
Publikováno v:
Acta biochimica et biophysica Sinica. 53(7)
Alzheimer's disease (AD) is one of the major life-threatening diseases for the elderly because neither pathogenesis nor effective treatment is available. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) has been shown to reduce the cell-damaging aldehy
Publikováno v:
Acta biochimica et biophysica Sinica. 52(8)
Abemaciclib is the newest cyclin-dependent kinase 4/6 inhibitor that has received approval from the US Food and Drug Administration for using in patients with advanced breast cancer. However, its potential adverse effects on cardiomyocytes remain unk
Publikováno v:
Acta biochimica et biophysica Sinica. 52(10)
Spontaneous abortion (SA) is the spontaneous loss of a pregnancy before 20 gestational weeks. The causes of SA are still largely unknown. Long noncoding RNA (lncRNA) urothelial cancer associated 1 (UCA1) plays an important role in cellular progress.
Publikováno v:
Acta biochimica et biophysica Sinica. 52(8)
The lysine histone demethylase KDM4B is overexpressed in several types of cancers and plays dual roles in genome stability maintenance. Although KDM4B is able to recognize several histone methylations, the underlying molecular mechanism is still unkn
Autor:
Shibing Deng, Sha-Ning Yang, Zhong-Quan Zhou, Zhiming Tian, Wanqing Shi, Xuying Yi, Xue-xin Yang, Li-Jun Jin, Songwen Chen
Publikováno v:
Acta biochimica et biophysica Sinica. 52(9)
Chronic hypoxia is a common inducer of end-stage cardiovascular disease. In cells under hypoxia, the hypoxia-inducible factor-1 (HIF-1) plays a vital role in regulating downstream target genes. However, the mechanism of hypoxia in cardiomyocytes is s