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pro vyhledávání: '"M. Kyle Hadden"'
Publikováno v:
ACS Med Chem Lett
[Image: see text] We conducted a structure–activity relationship study to explore simplified analogues of the itraconazole (ITZ) scaffold for their ability to inhibit the hedgehog (Hh) signaling pathway. These analogues were based on exploring the
Structure–Activity Relationships for Side Chain Oxysterol Agonists of the Hedgehog Signaling Pathway
Publikováno v:
ACS Medicinal Chemistry Letters. 3:828-833
Oxysterols (OHCs) are byproducts of cholesterol oxidation that are known to activate the Hedeghog (Hh) signaling pathway. While OHCs that incorporate hydroxyl groups throughout the scaffold are known, those that act as agonists of Hh signaling primar
Publikováno v:
ACS medicinal chemistry letters. 4(7)
Previous structure-activity relationship studies for vitamin D3 (VD3) inhibition of Hedgehog (Hh) signaling directed the design, synthesis, and evaluation of a series of VD3-based analogues that contain an aromatic A-ring mimic. Characterization of t