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pro vyhledávání: '"Dashyant Dhanak"'
Autor:
Martin Brandt, Caretha L. Creasy, Elsie Diaz, Benjamin Schwartz, Peter J. Tummino, Melissa B. Pappalardi, William H. Miller, Glenn S. Van Aller, Ryan G. Kruger, Sharad K. Verma, Heidi M. Ott, Dashyant Dhanak, Michael T. McCabe
Publikováno v:
ACS Chemical Biology. 9:622-629
EZH2/PRC2 catalyzes transcriptionally repressive methylation at lysine 27 of histone H3 and has been associated with numerous cancer types. Point mutations in EZH2 at Tyr641 and Ala677 identified in non-Hodgkin lymphomas alter substrate specificity a