Zobrazeno 1 - 10
of 474
pro vyhledávání: '"William R. Wilson"'
Autor:
Jingli Wang, William R. Wilson, Susan M. Pullen, Jiechuang Su, Huai-Ling Hsu, Francis W. Hunter
Supplementary Figures. Supplementary Figures including correlations of HAP sensitivity between cell lines, development and characterisation of doxycycline-inducible shRNA cell lines, and effect of BRCA2 knockout on radiation sensitivity of DLD-1 tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5024b37df1574f0ecb36039cae084bf4
https://doi.org/10.1158/1535-7163.22502809
https://doi.org/10.1158/1535-7163.22502809
Autor:
Jingli Wang, William R. Wilson, Susan M. Pullen, Jiechuang Su, Huai-Ling Hsu, Francis W. Hunter
Supplementary Tables. Supplementary Tables (including statistical analysis of relationships between one-electron reductase activity, HR status and chemosensitivity) and supplementary references related to this material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b74e544cf3021c52e6a78e33361d5e
https://doi.org/10.1158/1535-7163.22502806.v1
https://doi.org/10.1158/1535-7163.22502806.v1
Autor:
William R. Wilson, Larry H. Thompson, J. Martin Brown, Sophia B. Chernikova, Graham J. Atwell, Adam V. Patterson, Yongchuan Gu
PR-104 is a dinitrobenzamide mustard currently in clinical trial as a hypoxia-activated prodrug. Its major metabolite, PR-104A, is metabolized to the corresponding hydroxylamine (PR-104H) and amine (PR-104M), resulting in activation of the nitrogen m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b5326b845dbf44f19eae8363b03553
https://doi.org/10.1158/1535-7163.c.6531500
https://doi.org/10.1158/1535-7163.c.6531500
Autor:
William R. Wilson, Michael P. Hay, William A. Denny, J. Martin Brown, Mary Jo Dorie, H.D. Sarath Liyanage, Alison Hogg, Rita Patel, Annie M. Fraser, Frederik B. Pruijn, Jagdish K. Jaiswal, Bronwyn G. Siim, Kevin O. Hicks
Synthesis of SN30000, Tables S1-S4, and Figures S1-S6 from Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdb26519cf80e799e63eefd4ddfa2d9
https://doi.org/10.1158/1078-0432.22442168.v1
https://doi.org/10.1158/1078-0432.22442168.v1
Autor:
Moana Tercel, K. Jane Botting, Eileen Smith, H.D. Sarath Liyanage, Adam V. Patterson, Sophie P. Syddall, Frederik B. Pruijn, Stephen M. Stribbling, William R. Wilson
Supplementary Data from Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1a13337fc2c96e19e47692ba0a48b4
https://doi.org/10.1158/1535-7163.22482483.v1
https://doi.org/10.1158/1535-7163.22482483.v1
Autor:
William R. Wilson, Kevin O. Hicks, Michael P. Hay, Rita Patel, Jiechuang Su, Annika Foehrenbacher, Jingli Wang
CCR Translation for This Article from The 2-Nitroimidazole EF5 Is a Biomarker for Oxidoreductases That Activate the Bioreductive Prodrug CEN-209 under Hypoxia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe3cb753ac5e8665011c0cbd606edbd
https://doi.org/10.1158/1078-0432.22446111.v1
https://doi.org/10.1158/1078-0432.22446111.v1
Autor:
William R. Wilson, Kevin O. Hicks, Michael P. Hay, Rita Patel, Jiechuang Su, Annika Foehrenbacher, Jingli Wang
Purpose: Benzotriazine-N-oxide bioreductive prodrugs such as tirapazamine and its improved analogue CEN-209 (SN30000) have potential for exploiting hypoxia in tumors. Here, we test the hypothesis that the 2-nitroimidazole EF5, in clinical development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c0255dd9efc1f70819f54cce5562c6
https://doi.org/10.1158/1078-0432.c.6520650
https://doi.org/10.1158/1078-0432.c.6520650
Autor:
William R. Wilson, Larry H. Thompson, J. Martin Brown, Sophia B. Chernikova, Graham J. Atwell, Adam V. Patterson, Yongchuan Gu
Supplementary Data from Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ada6249849d71994885151e14523f66
https://doi.org/10.1158/1535-7163.22484627.v1
https://doi.org/10.1158/1535-7163.22484627.v1
Autor:
Moana Tercel, K. Jane Botting, Eileen Smith, H.D. Sarath Liyanage, Adam V. Patterson, Sophie P. Syddall, Frederik B. Pruijn, Stephen M. Stribbling, William R. Wilson
Hypoxia represents an important therapeutic target in tumors because of the resistance of hypoxic cells to radiotherapy and chemotherapy and because it is more severe in many tumors than in normal tissues. Here, we describe a class of prodrugs, nitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::714841c611cd9afe078394aa781cbc2d
https://doi.org/10.1158/1535-7163.c.6530940.v1
https://doi.org/10.1158/1535-7163.c.6530940.v1