Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Veronica Vella"'
Autor:
Veronica Veschi, Alice Turdo, Chiara Modica, Francesco Verona, Simone Di Franco, Miriam Gaggianesi, Elena Tirrò, Sebastiano Di Bella, Melania Lo Iacono, Vincenzo Davide Pantina, Gaetana Porcelli, Laura Rosa Mangiapane, Paola Bianca, Aroldo Rizzo, Elisabetta Sciacca, Irene Pillitteri, Veronica Vella, Antonino Belfiore, Maria Rita Bongiorno, Giuseppe Pistone, Lorenzo Memeo, Lorenzo Colarossi, Dario Giuffrida, Cristina Colarossi, Paolo Vigneri, Matilde Todaro, Giorgio Stassi
Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell subpopulation in the lineage hierarchy that serves as cell of origin for the different TC histotypes is unknown. Human embryonic stem cells (hESCs) with appropriate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4ed2705972e848de0cbd7d886a46ec
https://hdl.handle.net/10447/584013
https://hdl.handle.net/10447/584013
Autor:
Veronica Vella, Rosamaria Lappano, Eduardo Bonavita, Marcello Maggiolini, Robert Bryan Clarke, Antonino Belfiore, Ernestina Marianna De Francesco
Publikováno v:
Endocrine Reviews.
In metabolic conditions such as obesity and diabetes, which are associated with deregulated signaling of the insulin/insulin-like growth factor system (IIGFs), inflammation plays a dominant role. In cancer, IIGFs is implicated in disease progression,
Autor:
Antonino Belfiore, Rosaria Valentina Rapicavoli, Rosario Le Moli, Rosamaria Lappano, Andrea Morrione, Ernestina Marianna De Francesco, Veronica Vella
Insulin-like growth factor 2 (IGF2) is upregulated in both childhood and adult malignancies. Its overexpression is associated with resistance to chemotherapy and worse prognosis. However, our understanding of its physiological and pathological role i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92cacec41814760481d5ed97d0acbc9
https://hdl.handle.net/20.500.11769/547684
https://hdl.handle.net/20.500.11769/547684
Autor:
Rosario Le Moli, Veronica Vella, Dario Tumino, Tommaso Piticchio, Adriano Naselli, Antonino Belfiore, Francesco Frasca
Publikováno v:
Frontiers in Endocrinology. 13
Obesity is strongly associated with chronic low-grade inflammation. Obese patients have an increased risk to develop thyroid autoimmunity and to became hypothyroid, suggesting a pathogenetic link between obesity, inflammation and autoimmunity. Moreov
Autor:
Domenica Scordamaglia, Francesca Cirillo, Marianna Talia, Maria Francesca Santolla, Damiano Cosimo Rigiracciolo, Lucia Muglia, Azzurra Zicarelli, Salvatore De Rosis, Francesca Giordano, Anna Maria Miglietta, Ernestina Marianna De Francesco, Veronica Vella, Antonino Belfiore, Rosamaria Lappano, Marcello Maggiolini
Publikováno v:
Journal of translational medicine. 20(1)
Background Metabolic disorders are associated with increased incidence, aggressive phenotype and poor outcome of breast cancer (BC) patients. For instance, hyperinsulinemia is an independent risk factor for BC and the insulin/insulin receptor (IR) ax
Autor:
Veronica Vella, Ernestina Marianna De Francesco, Eduardo Bonavita, Rosamaria Lappano, Antonino Belfiore
Publikováno v:
Trends in endocrinology and metabolism: TEM. 33(8)
Type I interferons (IFN-Is) are prototypical inflammatory cytokines produced in response to stress. IFN-Is have a critical role in antitumor immunity by driving the activation of leukocytes and favoring the elimination of malignant cells. However, IF
Autor:
Roberta Malaguarnera, Caterina Gabriele, Gianluca Santamaria, Marika Giuliano, Veronica Vella, Michele Massimino, Paolo Vigneri, Giovanni Cuda, Marco Gaspari, Antonino Belfiore
Publikováno v:
Molecular and cellular endocrinology. 557
The insulin receptor (IR) gene undergoes differential splicing generating two IR isoforms, IR-A and IR-B. The roles of IR-A in cancer and of IR-B in metabolic regulation are well known but the molecular mechanisms responsible for their different biol
Autor:
Ernestina Marianna De Francesco, Francesca Cirillo, Veronica Vella, Antonino Belfiore, Marcello Maggiolini, Rosamaria Lappano
Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by the lack of estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor 2 (HER2) and often associated with poor survival outcomes. The backb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4388a8da585a712fda7c5c1d7a0109
https://hdl.handle.net/20.500.11769/541369
https://hdl.handle.net/20.500.11769/541369
Autor:
Veronica Vella, Ernestina Marianna De Francesco, Alfredo Pulvirenti, Michele Pellegrino, Paolo Vigneri, Alessandra Dicitore, Antonino Belfiore, Marika Giuliano, Michele Massimino, Rosamaria Lappano, Andrea Morrione, Alessandro La Ferlita, Germano Gaudenzi, Andrew H. Sims, Marcello Maggiolini, Roberta Malaguarnera, Salvatore Alaimo, Giovanni Vitale, Alfredo Ferro
Publikováno v:
Cells, Vol 10, Iss 3145, p 3145 (2021)
Cells
Volume 10
Issue 11
Vella, V, Giuliano, M, La Ferlita, A, Pellegrino, M, Gaudenzi, G, Alaimo, S, Massimino, M, Pulvirenti, A, Dicitore, A, Vigneri, P, Vitale, G, Malaguarnera, R, Morrione, A, Sims, A H, Ferro, A, Maggiolini, M, Lappano, R, De Francesco, E M & Belfiore, A 2021, ' Novel Mechanisms of Tumor Promotion by the Insulin Receptor Isoform A in Triple-Negative Breast Cancer Cells ', Cells, vol. 10, no. 11, pp. 3145 . https://doi.org/10.3390/cells10113145
Cells
Volume 10
Issue 11
Vella, V, Giuliano, M, La Ferlita, A, Pellegrino, M, Gaudenzi, G, Alaimo, S, Massimino, M, Pulvirenti, A, Dicitore, A, Vigneri, P, Vitale, G, Malaguarnera, R, Morrione, A, Sims, A H, Ferro, A, Maggiolini, M, Lappano, R, De Francesco, E M & Belfiore, A 2021, ' Novel Mechanisms of Tumor Promotion by the Insulin Receptor Isoform A in Triple-Negative Breast Cancer Cells ', Cells, vol. 10, no. 11, pp. 3145 . https://doi.org/10.3390/cells10113145
The insulin receptor isoform A (IR-A) plays an increasingly recognized role in fetal growth and tumor biology in response to circulating insulin and/or locally produced IGF2. This role seems not to be shared by the IR isoform B (IR-B). We aimed to di