Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Tobias L. Lenz"'
Publikováno v:
Frontiers in Immunology. 14
The human leukocyte antigen (HLA) proteins are an indispensable component of adaptive immunity because of their role in presenting self and foreign peptides to T cells. Further, many complex diseases are associated with genetic variation in the HLA r
Autor:
Jan Stephan Wichers-Misterek, Annika M. Binder, Paolo Mesén-Ramírez, Lilian Patrick Dorner, Soraya Safavi, Gwendolin Fuchs, Tobias L. Lenz, Anna Bachmann, Danny Wilson, Friedrich Frischknecht, Tim-Wolf Gilberger
Publikováno v:
mBio. 14
A key structural feature driving the transition between different life cycle stages of the malaria parasite is the unique three-membrane pellicle, consisting of the parasite plasma membrane (PPM) and a double membrane structure underlying the PPM ter
Autor:
Doko-Miles J. Thorburn, Kostas Sagonas, Mahesh Binzer-Panchal, Frederic J.J. Chain, Philine G.D. Feulner, Erich Bornberg-Bauer, Thorsten BH Reusch, Irene E. Samonte-Padilla, Manfred Milinski, Tobias L. Lenz, Christophe Eizaguirre
Genome-level sequencing enables us to ask fundamental questions about the genetic basis of adaptation, population structure, and epigenetic mechanisms, but usually requires a suitable reference genome for mapping population-level re-sequencing data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b00dad3a376a88ac381d52be59125bf
https://doi.org/10.1101/2023.01.10.523267
https://doi.org/10.1101/2023.01.10.523267
Publikováno v:
Diversity; Volume 14; Issue 11; Pages: 925
The major histocompatibility complex (MHC) is a multi-copy immune gene family in vertebrates. Its genes are highly variable and code for antigen-presenting molecules. Characterization of MHC genes in different species and investigating the mechanisms
Autor:
Jan Stephan Wichers-Misterek, Annika M. Binder, Paolo Mesén-Ramírez, Lilian Patrick Dorner, Soraya Safavi, Gwendolin Fuchs, Tobias L. Lenz, Anna Bachmann, Danny Wilson, Friedrich Frischknecht, Tim-Wolf Gilberger
Mature gametocytes ofPlasmodium(P.)falciparumdisplay a banana (falciform) shape conferred by a complex array of subpellicular microtubules (SPMT) associated to the inner membrane complex (IMC). Microtubule associated proteins (MAPs) define MT populat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1bd44fb17ae715e3cf9cdb28fe685d1
https://doi.org/10.1101/2022.10.18.512810
https://doi.org/10.1101/2022.10.18.512810
Autor:
Hesham ElAbd, Mareike Wendorff, Tomas Koudelka, Christian Hentschker, Ann-Kristin Kamps, Christoph Prieß, Lars Wienbrandt, Frauke Degenhardt, Tim A. Steiert, Petra Bacher, Piyush Mathur, David Ellinghaus, Uwe Völker, Andreas Tholey, Tobias L. Lenz, Andre Franke
The human leukocyte antigen (HLA) class II proteins present peptides to CD4+T cells through an interaction with T cell receptors (TCRs). Thus, HLA proteins are key players in shaping immunogenicity and immunodominance. Nevertheless, factors governing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b67f56c6aea243c99a8307c96339950
https://doi.org/10.1101/2022.09.20.508681
https://doi.org/10.1101/2022.09.20.508681
Autor:
Saori Sakaue, Saisriram Gurajala, Michelle Curtis, Yang Luo, Wanson Choi, Kazuyoshi Ishigaki, Joyce B. Kang, Laurie Rumker, Aaron J. Deutsch, Sebastian Schönherr, Lukas Forer, Jonathon LeFaive, Christian Fuchsberger, Buhm Han, Tobias L. Lenz, Paul I. W. de Bakker, Albert V. Smith, Soumya Raychaudhuri
The human leukocyte antigen (HLA) locus is associated with more human complex diseases than any other locus. In many diseases it explains more heritability than all other known loci combined. Investigators have now demonstrated the accuracy of in sil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8b3ad5aee07cb83fb84c1f824dbab0f
https://doi.org/10.1101/2022.08.24.504550
https://doi.org/10.1101/2022.08.24.504550
Autor:
Zhiwei Liu, Chih-Jen Huang, Yu-Han Huang, Mei-Hung Pan, Mei-Hsuan Lee, Mathias Viard, Allan Hildesheim, Ruth M. Pfeiffer, Mary Carrington, Chien-Jen Chen, Tobias L. Lenz, Hwai-I Yang
Publikováno v:
Cancer Research. 83:3013-3013
Background: The reported associations of genetic variants within the human leukocyte antigen (HLA) region with hepatis B virus (HBV)-related hepatocellular carcinoma (HCC) are not consistent, and the structure-function patterns involved in this disea
Publikováno v:
Frontiers in immunology. 13
Structural and functional variability of human leukocyte antigen (HLA) is the foundation for competent adaptive immune responses against pathogen and tumor antigens as it assures the breadth of the presented immune-peptidome, theoretically sustaining
Autor:
Mette-Triin Purde, Rebekka Niederer, Nikolaus B. Wagner, Stefan Diem, Fiamma Berner, Omar Hasan Ali, Dorothea Hillmann, Irina Bergamin, Markus Joerger, Martin Risch, Christoph Niederhauser, Tobias L. Lenz, Martin Früh, Lorenz Risch, David Semela, Lukas Flatz
Publikováno v:
Purde, Mette‑Triin; Niederer, Rebekka; Wagner, ikolaus B.; Diem, Stefan; Berner, Fiamma; Hasan Ali, Omar; Hillmann, Dorothea; Bergamin, Irina; Joerger, Markus; Risch, Martin; Niederhauser, Christoph; Lenz, Tobias L.; Früh, Martin; Risch, Lorenz; Semela, David; Flatz, Lukas (2022). Presence of autoantibodies in serum does not impact the occurrence of immune checkpoint inhibitor-induced hepatitis in a prospective cohort of cancer patients. Journal of cancer research and clinical oncology, 148(3), pp. 647-656. Springer 10.1007/s00432-021-03870-6
Journal of Cancer Research and Clinical Oncology
Journal of Cancer Research and Clinical Oncology
Purpose Immune checkpoint inhibitor (ICI)-induced hepatitis belongs to the frequently occurring immune-related adverse events (irAEs), particularly with the combination therapy involving ipilimumab and nivolumab. However, predisposing factors predict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812bf92bad1e3210e93f155d71738545
https://boris.unibe.ch/162047/1/Purde2021_Article_PresenceOfAutoantibodiesInSeru.pdf
https://boris.unibe.ch/162047/1/Purde2021_Article_PresenceOfAutoantibodiesInSeru.pdf