Zobrazeno 1 - 10
of 255
pro vyhledávání: '"Tilman Kühn"'
Autor:
Mazda Jenab, W. Robert Bruce, Elio Riboli, Amanda J. Cross, Marc J. Gunter, Pietro Ferrari, Faidra Stavropoulou, Heinz Freisling, Kathryn E. Bradbury, Kay-Tee Khaw, Nicholas J. Wareham, Mårten Werner, Miren Dorronsoro, Aurelio Barricarte, José María Huerta Castaño, María-José Sánchez, Núria Sala, J. Ramón Quirós, Elisabete Weiderpass, Petra H. Peeters, H.B. Bueno-de-Mesquita, Alessio Naccarati, Rosario Tumino, Amalia Mattiello, Vittorio Krogh, Domenico Palli, Effie Vasilopoulou, Maria Kritikou, Antonia Trichopoulou, Krasimira Aleksandrova, Heiner Boeing, Rudolf Kaaks, Tilman Kühn, Aurélie Affret, Nadia Bastide, Marie-Christine Boutron-Ruault, Kim Overvad, Anja Olsen, Anne Tjønneland, Isabelle Romieu, Veronika Fedirko, Gail McKeown-Eyssen, Andrew T. Gewirtz, Hao Quang Tran, So Yeon Kong
Background: Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer development. These processes may contribute to leakage of bacterial products, such as lipopolysaccharide (LPS) and flagellin, across the gut barrier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84bf8fc98629dfa27ee9ee0c1a4c4ac4
https://doi.org/10.1158/1055-9965.c.6516039
https://doi.org/10.1158/1055-9965.c.6516039
Autor:
Rudolf Kaaks, Elio Riboli, Ioanna Tzoulaki, Melissa A. Merritt, Pietro Ferrari, Kuanrong Li, Laure Dossus, Ruth C. Travis, Kay-Tee Khaw, Pilar Amiano, Aurelio Barricarte, Maria-Dolores Chirlaque, Maria-Jose Sánchez, Antonio Agudo, J. Ramón Quirós, Carla H. van Gills, Petra H. Peeters, H. Bas Bueno de Mesquita, Salvatore Panico, Francesca Fasanelli, Rosario Tumino, Valeria Pala, Giovanna Masala, Philippos Orfanos, Vassiliki Benetou, Antonia Trichopoulou, Heiner Boeing, Agnes Fournier, Gianluca Severi, Marie-Christine Boutron-Ruault, Anja Olsen, Anne Tjønneland, Kim Overvad, Tilman Kühn, Renée T. Fortner, Anika Hüsing
Purpose: Circulating hormone concentrations are associated with breast cancer risk, with well-established associations for postmenopausal women. Biomarkers may represent minimally invasive measures to improve risk prediction models.Experimental Desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c33f7307f333f48f26b74da9612285e4
https://doi.org/10.1158/1078-0432.c.6526937.v1
https://doi.org/10.1158/1078-0432.c.6526937.v1
Autor:
Mazda Jenab, W. Robert Bruce, Elio Riboli, Amanda J. Cross, Marc J. Gunter, Pietro Ferrari, Faidra Stavropoulou, Heinz Freisling, Kathryn E. Bradbury, Kay-Tee Khaw, Nicholas J. Wareham, Mårten Werner, Miren Dorronsoro, Aurelio Barricarte, José María Huerta Castaño, María-José Sánchez, Núria Sala, J. Ramón Quirós, Elisabete Weiderpass, Petra H. Peeters, H.B. Bueno-de-Mesquita, Alessio Naccarati, Rosario Tumino, Amalia Mattiello, Vittorio Krogh, Domenico Palli, Effie Vasilopoulou, Maria Kritikou, Antonia Trichopoulou, Krasimira Aleksandrova, Heiner Boeing, Rudolf Kaaks, Tilman Kühn, Aurélie Affret, Nadia Bastide, Marie-Christine Boutron-Ruault, Kim Overvad, Anja Olsen, Anne Tjønneland, Isabelle Romieu, Veronika Fedirko, Gail McKeown-Eyssen, Andrew T. Gewirtz, Hao Quang Tran, So Yeon Kong
Supplemental Table S1: ORs (95% CI) for risk of CRC by quartiles of baseline biomarkers of anti-LPS- and antiflagellin- IgA and IgG. Supplemental Table S2: ORs (95% CI) for risk of CRC by increasing levels of total bacterial exposure and high sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7533a55f7c10a5b4105e366bcb38c56e
https://doi.org/10.1158/1055-9965.22437783.v1
https://doi.org/10.1158/1055-9965.22437783.v1
Autor:
Rudolf Kaaks, Sven Olek, Theron Johnson, Tilman Kühn, Verena A. Katzke, Sandra González Maldonado, Renée T. Fortner, Araceli Rossello Chornet, Konstantin Schildknecht, Charlotte Le Cornet
Table S1 shows partial Spearman correlations between relative immune cell count adjusted for age at blood collection and sex within the subcohort. Table S2 shows cross-sectional associations of circulating immune cell composition and various covariat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e061c75a1c2cd0c4411920c37ff376
https://doi.org/10.1158/0008-5472.22424692
https://doi.org/10.1158/0008-5472.22424692
Autor:
Rudolf Kaaks, Sven Olek, Theron Johnson, Tilman Kühn, Verena A. Katzke, Sandra González Maldonado, Renée T. Fortner, Araceli Rossello Chornet, Konstantin Schildknecht, Charlotte Le Cornet
Supplementary Figure S1. Stacked bar charts of normalized immune cell counts across strata of baseline characteristics in the sub-cohort (n = 465).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6672af96e72a0f0f26ea30f9d89d9fe4
https://doi.org/10.1158/0008-5472.22424695.v1
https://doi.org/10.1158/0008-5472.22424695.v1
Autor:
Rudolf Kaaks, Sven Olek, Theron Johnson, Tilman Kühn, Verena A. Katzke, Sandra González Maldonado, Renée T. Fortner, Araceli Rossello Chornet, Konstantin Schildknecht, Charlotte Le Cornet
Although ample evidence indicates that immune cell homeostasis is an important prognostic outcome determinant in patients with cancer, few studies have examined whether it also determines cancer risk among initially healthy individuals. We performed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b96b1af2749dd9203b1d8f64d8734bc8
https://doi.org/10.1158/0008-5472.c.6511846.v1
https://doi.org/10.1158/0008-5472.c.6511846.v1
Autor:
Rudolf Kaaks, Elio Riboli, Ioanna Tzoulaki, Melissa A. Merritt, Pietro Ferrari, Kuanrong Li, Laure Dossus, Ruth C. Travis, Kay-Tee Khaw, Pilar Amiano, Aurelio Barricarte, Maria-Dolores Chirlaque, Maria-Jose Sánchez, Antonio Agudo, J. Ramón Quirós, Carla H. van Gills, Petra H. Peeters, H. Bas Bueno de Mesquita, Salvatore Panico, Francesca Fasanelli, Rosario Tumino, Valeria Pala, Giovanna Masala, Philippos Orfanos, Vassiliki Benetou, Antonia Trichopoulou, Heiner Boeing, Agnes Fournier, Gianluca Severi, Marie-Christine Boutron-Ruault, Anja Olsen, Anne Tjønneland, Kim Overvad, Tilman Kühn, Renée T. Fortner, Anika Hüsing
Supplemental Table 1 shows associations between candidate biomarkers and breast cancer risk in women postmenopausal at blood collection using 5-year risk from Pfeiffer's model as a regression offset. ORs are estimated per doubling of concentration (f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de01b26a68763c158d29715560104cf
https://doi.org/10.1158/1078-0432.22468439.v1
https://doi.org/10.1158/1078-0432.22468439.v1
Publikováno v:
European Journal of Epidemiology
Srour, B, Kaaks, R, Johnson, T, Hynes, L C, Kühn, T & Katzke, V A 2021, ' Ageing-related markers and risks of cancer and cardiovascular disease: a prospective study in the EPIC-Heidelberg cohort ', European Journal of Epidemiology . https://doi.org/10.1007/s10654-021-00828-3
Srour, B, Kaaks, R, Johnson, T, Hynes, L C, Kühn, T & Katzke, V A 2021, ' Ageing-related markers and risks of cancer and cardiovascular disease: a prospective study in the EPIC-Heidelberg cohort ', European Journal of Epidemiology . https://doi.org/10.1007/s10654-021-00828-3
Biological age is an important risk factor for chronic diseases. We examined the associations between five markers of unhealthy ageing; Growth Differentiation Factor-15 (GDF-15), N-terminal pro-brain natriuretic peptide (NT-proBNP), glycated hemoglob
Autor:
Sibylle Stoll, Solomon A. Sowah, Matthias A. Fink, Tobias Nonnenmacher, Mirja E. Graf, Theron Johnson, Christopher L. Schlett, Oyunbileg von Stackelberg, Romy Kirsten, Fabian Bamberg, Jeffrey Keller, Cornelia M. Ulrich, Rudolf Kaaks, Hans-Ulrich Kauczor, Fabian Rengier, Tilman Kühn, Johanna Nattenmüller
Publikováno v:
Frontiers in Physiology. 13
Obesity-related metabolic disorders such as hypertension, hyperlipidemia and chronic inflammation have been associated with aortic dilatation and resulting in aortic aneurysms in many cases. Whether weight loss may reduce the risk of aortic dilatatio
Autor:
Catarina Schiborn, Rebecca Paprott, Christin Heidemann, Tilman Kühn, Andreas Fritsche, Rudolf Kaaks, Matthias B. Schulze
Publikováno v:
Dtsch Arztebl Int
Schiborn, C, Paprott, R, Heidemann, C, Kühn, T, Fritsche, A, Kaaks, R & Schulze, M B 2022, ' German diabetes risk score for the determination of the individual type 2 diabetes risk. 10-year prediction and external validations ', Deutsches Arzteblatt international, vol. 119, pp. 651-657 . https://doi.org/10.3238/arztebl.m2022.0268
Schiborn, C, Paprott, R, Heidemann, C, Kühn, T, Fritsche, A, Kaaks, R & Schulze, M B 2022, ' German diabetes risk score for the determination of the individual type 2 diabetes risk. 10-year prediction and external validations ', Deutsches Arzteblatt international, vol. 119, pp. 651-657 . https://doi.org/10.3238/arztebl.m2022.0268
BACKGROUND: The German Diabetes Risk Score (GDRS) currently enables prediction of the individual risk of developing type 2 diabetes (T2D) within five years. The aim of this study is to extend the prediction period of the GDRS, including its non-clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1eb01c1972934e2bf5e03855b4aaaf5
https://europepmc.org/articles/PMC9811545/
https://europepmc.org/articles/PMC9811545/