Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Shirin Arastu-Kapur"'
Autor:
Christopher J. Kirk, Andrew J. Ball, Christoph Driessen, Mark K. Bennett, Tony Muchamuel, Susan J. Lee, Kevin D. Shenk, Francesco Parlati, Marianne Kraus, Janet L. Anderl, Shirin Arastu-Kapur
Supplementary Figures S1-S4; Supplementary Tables S1-S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e20c3ba1cf4d484b2bffd0c91ffc79d
https://doi.org/10.1158/1078-0432.22442163.v1
https://doi.org/10.1158/1078-0432.22442163.v1
Autor:
Christopher J. Kirk, Andrew J. Ball, Christoph Driessen, Mark K. Bennett, Tony Muchamuel, Susan J. Lee, Kevin D. Shenk, Francesco Parlati, Marianne Kraus, Janet L. Anderl, Shirin Arastu-Kapur
Purpose: Bortezomib (Velcade), a dipeptide boronate 20S proteasome inhibitor and an approved treatment option for multiple myeloma, is associated with a treatment-emergent, painful peripheral neuropathy (PN) in more than 30% of patients. Carfilzomib,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0675242182dc136a28da04501a408a42
https://doi.org/10.1158/1078-0432.c.6518973
https://doi.org/10.1158/1078-0432.c.6518973
Autor:
Sean Broce, Florian Ermini, Leslie J. Holsinger, Stephen S. Dominy, Michael J. Detke, Leo Rodriguez, Ursula Haditsch, Casey C. Lynch, D. David Hennings, Mai Nguyen, Jianhong Wang, Shirin Arastu-Kapur, Debasish Raha
Publikováno v:
SSRN Electronic Journal.
Gingipains are protease virulence factors from the periodontal bacterial pathogen Porphyromonas gingivalis and were recently identified in greater than 90% of Alzheimer’s disease (AD) brains. Studies in wild-type mice and rats have demonstrated tha
Autor:
Florian Ermini, Debasish Raha, Mai Nguyen, Leslie J. Holsinger, Casey C. Lynch, Mark I. Ryder, Stephen S. Dominy, Ines A. M. De Lannoy, Ursula Haditsch, Joseph Araujo, Shirin Arastu-Kapur
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology research & perspectives, vol 8, iss 1
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
Pharmacology research & perspectives, vol 8, iss 1
Pharmacology Research & Perspectives, Vol 8, Iss 1, Pp n/a-n/a (2020)
COR388, a small‐molecule lysine‐gingipain inhibitor, is currently being investigated in a Phase 2/3 clinical trial for Alzheimer's disease (AD) with exploratory endpoints in periodontal disease. Gingipains are produced by two species of bacteria,
Autor:
Erin Bradley, Lisa M. Kelly, Janet L. Anderl, Eric Lowe, David C. Moebius, Jeffrey Jones, Shirin Arastu-Kapur, Christopher J. Kirk, Henry W. B. Johnson, John Bui, Zhengping Wang, Dustin McMinn, Tony Muchamuel
Publikováno v:
ACS Medicinal Chemistry Letters. 8:413-417
Building upon the success of bortezomib (VELCADE) and carfilzomib (KYPROLIS), the design of a next generation of inhibitors targeting specific subunits within the immunoproteasome is of interest for the treatment of autoimmune disease. There are thre
Autor:
Marcin Drag, Fang Yuan, Katarzyna Groborz, Martin Horn, Edgar Deu, Chrislaine Withers-Martinez, Laurie Kuppens, Neysa Nevins, Shirin Arastu-Kapur, Matthew Bogyo, Michael Mareš, Mateo I. Sánchez, Christine Lehmann, David Jonathan Hirst, Marcin Poreba, Laura E. de Vries
Publikováno v:
FEBS Journal, 286, 20, pp. 3998-4023
The Febs Journal
FEBS Journal, 286, 3998-4023
The Febs Journal
FEBS Journal, 286, 3998-4023
Malarial dipeptidyl aminopeptidases (DPAPs) are cysteine proteases important for parasite development thus making them attractive drug targets. In order to develop inhibitors specific to the parasite enzymes, it is necessary to map the determinants o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119003c3d9face13e10fdaba3ed3a2db
https://hdl.handle.net/2066/209409
https://hdl.handle.net/2066/209409
Autor:
Florian Ermini, Samer Kaba, Jan Potempa, Christina Griffin, Stephen S. Dominy, Malgorzata Benedyk, Debasish Raha, Agata Marczyk, Glenn D Walker, Casey C. Lynch, Mai Nguyen, Piotr Mydel, Annelie Hellvard, Eric C. Reynolds, Hatice Hasturk, Ursula Haditsch, Andrei Konradi, Maurice A. Curtis, Richard L.M. Faull, Leslie J. Holsinger, Mark I. Ryder, Karina Adamowicz, Mike Dragunow, Barbara Potempa, Shirin Arastu-Kapur, Alexander Lee
Publikováno v:
Science advances, vol 5, iss 1
Science Advances
Science Advances
Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors.
Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s dise
Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer’s dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883a50af9b4a731c268d542b0ea8cca6
https://ruj.uj.edu.pl/xmlui/handle/item/80007
https://ruj.uj.edu.pl/xmlui/handle/item/80007
Autor:
Ravi Vij, Kyriakos P. Papadopoulos, Alvin F. Wong, Lois Kellerman, Francesco Parlati, Susan Lee, Sundar Jagannath, Gregory J. Ahmann, Ashraf Badros, Michael Wang, Christopher J. Kirk, Mark K. Bennett, Shirin Arastu-Kapur, Konstantin Levitsky, David S. Siegel, Tina F. Woo, Ruben Niesvizky
Publikováno v:
British Journal of Haematology
Summary While proteasome inhibition is a validated therapeutic approach for multiple myeloma (MM), inhibition of individual constitutive proteasome (c20S) and immunoproteasome (i20S) subunits has not been fully explored owing to a lack of effective t
Autor:
Michael S. Gordon, Shirin Arastu-Kapur, Hansen L. Wong, Johanna C. Bendell, Jeffrey R. Infante, Howard A. Burris, Anthony W. Tolcher, David S. Mendelson, Heidi H. Gillenwater, Kyriakos P. Papadopoulos
Publikováno v:
Investigational New Drugs. 34:216-224
Purpose To determine the dose-limiting toxicities (DLTs), maximum tolerated dose (MTD), safety, and pharmacokinetic and pharmacodynamic profiles of the tripeptide epoxyketone proteasome inhibitor oprozomib in patients with advanced refractory or recu
Autor:
Anthony J. O’Donoghue, Florencia La Greca, Charles S. Craik, Matthew Ravalin, Peter Cimermancic, Andrej Sali, Francesco Caiazza, Michael B. Winter, Janet L. Anderl, Markus-Frederik Bohn, Shirin Arastu-Kapur, Tonia J Buchholz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20ab4dbfa807911d65edfd35648792bf
https://doi.org/10.7554/elife.27364.030
https://doi.org/10.7554/elife.27364.030