Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sander Barnhoorn"'
Autor:
Akos Gyenis, Jiang Chang, Joris J. P. G. Demmers, Serena T. Bruens, Sander Barnhoorn, Renata M. C. Brandt, Marjolein P. Baar, Marko Raseta, Kasper W. J. Derks, Jan H. J. Hoeijmakers, Joris Pothof
Publikováno v:
Nature Genetics, 55(2), 268-279. Nature Publishing Group
Gene expression profiling has identified numerous processes altered in aging, but how these changes arise is largely unknown. Here we combined nascent RNA sequencing and RNA polymerase II chromatin immunoprecipitation followed by sequencing to elucid
Autor:
Martine de Boer, Maaike te Lintel Hekkert, Jiang Chang, Bibi S. van Thiel, Leonie Martens, Maxime M. Bos, Marion G. J. de Kleijnen, Yanto Ridwan, Yanti Octavia, Elza D. van Deel, Lau A. Blonden, Renata M. C. Brandt, Sander Barnhoorn, Paula K. Bautista‐Niño, Ilona Krabbendam‐Peters, Rianne Wolswinkel, Banafsheh Arshi, Mohsen Ghanbari, Christian Kupatt, Leon J. de Windt, A. H. Jan Danser, Ingrid van der Pluijm, Carol Ann Remme, Monika Stoll, Joris Pothof, Anton J. M. Roks, Maryam Kavousi, Jeroen Essers, Jolanda van der Velden, Jan H. J. Hoeijmakers, Dirk J. Duncker
Publikováno v:
Aging cell, 22(3):e13768. Wiley-Blackwell
Aging Cell, 22(3):e13768. Wiley-Blackwell
Aging Cell, 22(3):e13768. Wiley-Blackwell Publishing Ltd
Aging Cell, 22(3):e13768. Wiley-Blackwell
Aging Cell, 22(3):e13768. Wiley-Blackwell Publishing Ltd
Heart failure has reached epidemic proportions in a progressively ageing population. The molecular mechanisms underlying heart failure remain elusive, but evidence indicates that DNA damage is enhanced in failing hearts. Here, we tested the hypothesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34433d6931f0ede9d081e90be6bfb43
https://pure.amc.nl/en/publications/dna-repair-in-cardiomyocytes-is-critical-for-maintaining-cardiac-function-in-mice(21e8677d-25c0-47aa-84ec-5bb5b6226d51).html
https://pure.amc.nl/en/publications/dna-repair-in-cardiomyocytes-is-critical-for-maintaining-cardiac-function-in-mice(21e8677d-25c0-47aa-84ec-5bb5b6226d51).html
Autor:
María B. Birkisdóttir, Ivar van Galen, Renata M. C. Brandt, Sander Barnhoorn, Nicole van Vliet, Claire van Dijk, Bhawani Nagarajah, Sandra Imholz, Conny T. van Oostrom, Erwin Reiling, Ákos Gyenis, Pier G. Mastroberardino, Dick Jaarsma, Harry van Steeg, Jan H. J. Hoeijmakers, Martijn E. T. Dollé, Wilbert P. Vermeij
Publikováno v:
Frontiers in aging, 3:1005322
Despite efficient repair, DNA damage inevitably accumulates with time affecting proper cell function and viability, thereby driving systemic aging. Interventions that either prevent DNA damage or enhance DNA repair are thus likely to extend health- a
Autor:
Joyce Burger, Ingrid van der Pluijm, Andy Willaert, Marjolijn Renard, Sander Barnhoorn, Bert Callewaert, Marine Vanhomwegen, Annekatrien Boel, Benedicte Descamps, Christian Vanhove, Paul Coucke, Jeroen Essers, Christophe Casteleyn, Aude Beyens, Dieter P. Reinhardt
Publikováno v:
Human Molecular Genetics, 29(9), 1476-1488. Oxford University Press
Arterial tortuosity syndrome (ATS) is a recessively inherited connective tissue disorder, mainly characterized by tortuosity and aneurysm formation of the major arteries. ATS is caused by loss-of-function mutations in SLC2A10, encoding the facilitati
Autor:
Trisha V. Kers, Romain Tching Chi Yen, Martine L.M. Lamfers, Clemens M F Dirven, Stijn L.W. Koolen, Ioannis Ntafoulis, Pim J. French, César Payán-Gómez, Cassandra Verheul, E.A. Struys, Sander Barnhoorn, Pier G. Mastroberardino, Youri Hoogstrate, Sieger Leenstra
BackgroundMutations of the isocitrate dehydrogenase (IDH) gene occur in over 80% of low-grade gliomas and secondary glioblastomas. Despite considerable efforts, endogenous in vitro IDH-mutated glioma models remain scarce. Availability of these models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e760ff32ce5e7dda6a29f7bb4a3fd1d
https://doi.org/10.1101/2021.04.09.435131
https://doi.org/10.1101/2021.04.09.435131
Autor:
Harry van Steeg, Jan H.J. Hoeijmakers, Sander Barnhoorn, Renata M. C. Brandt, Anton J.M. Roks, Ype Elgersma, Bhawani Nagarajah, Dick Jaarsma, Jeroen L. A. Pennings, Martijn E.T. Dollé, José A. Ferreira, Eliana Portilla Fernandez, Wilbert P. Vermeij, María B. Birkisdóttir, Sandra Imholz, Conny T. M. van Oostrom, Nicole van Vliet
Publikováno v:
Aging Cell
Aging Cell, 20(2):e13302. Wiley-Blackwell Publishing Ltd
Aging Cell, 20(2):e13302. Wiley-Blackwell Publishing Ltd
Dietary restriction (DR) and rapamycin extend healthspan and life span across multiple species. We have recently shown that DR in progeroid DNA repair‐deficient mice dramatically extended healthspan and trippled life span. Here, we show that rapamy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c2ab8994468dc55a3c4d109485e171
http://hdl.handle.net/10029/624666
http://hdl.handle.net/10029/624666
Autor:
Simona V. Gornati, Ayse Ulusoy, Donato A. Di Monte, Chiara Milanese, Daniel F. Wallace, Pier Giorgio Mastroberardino, Sander Barnhoorn, Fabio Blandini, Silvia Cerri, V. Nathan Subramaniam, Sylvia Gabriels
Publikováno v:
Cell death and differentiation 28(5), 1720-1732 (2021). doi:10.1038/s41418-020-00698-4
Cell Death and Differentiation
Cell Death and Differentiation, 28(5), 1720-1732. Nature Publishing Group
Cell Death and Differentiation
Cell Death and Differentiation, 28(5), 1720-1732. Nature Publishing Group
Alterations in the metabolism of iron and its accumulation in the substantia nigra pars compacta accompany the pathogenesis of Parkinson’s disease (PD). Changes in iron homeostasis also occur during aging, which constitutes a PD major risk factor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33103840c384a4b784bbebe56a2f5c1
Autor:
W.J. Koevoet, Pier G. Mastroberardino, Chantal Voskamp, Sander Barnhoorn, Roberto Narcisi, G.J.V.M. van Osch, Laura A. Anderson
Publikováno v:
European cells & materials, 42, 401-414. AO Research Institute
European Cells & Materials, Vol 42, Pp 401-414 (2021)
European Cells & Materials, Vol 42, Pp 401-414 (2021)
Mesenchymal stem cells (MSC) are promising cells for regenerative medicine therapies, because they can differentiate towards multiple cell lineages. However, heterogeneity in differentiation capacity is one of the main drawbacks that limit their use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4b827ec768389dcfd7f940b45ffedd
https://hdl.handle.net/11697/195409
https://hdl.handle.net/11697/195409
Autor:
César Payán-Gómez, Martine L.M. Lamfers, Pier G. Mastroberardino, Ioannis Ntafoulis, Stijn L.W. Koolen, Pim J. French, Trisha V. Kers, Clemens M F Dirven, Cassandra Verheul, E.A. Struys, Youri Hoogstrate, Romain Tching Chi Yen, Sieger Leenstra, Sander Barnhoorn
Publikováno v:
Neuro-Oncology Advances, 3(1):vdab103. Oxford University Press
Verheul, C, Ntafoulis, I, Kers, T V, Hoogstrate, Y, Mastroberardino, P G, Barnhoorn, S, Payán-Gómez, C, Tching Chi Yen, R, Struys, E A, Koolen, S L W, Dirven, C M F, Leenstra, S, French, P J & Lamfers, M L M 2021, ' Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell cultures ', Neuro-oncology advances, vol. 3, no. 1, vdab103 . https://doi.org/10.1093/noajnl/vdab103
Neuro-oncology advances, 3(1):vdab103. Oxford University Press
Neuro-Oncology Advances
Neuro-oncology Advances
Verheul, C, Ntafoulis, I, Kers, T V, Hoogstrate, Y, Mastroberardino, P G, Barnhoorn, S, Payán-Gómez, C, Tching Chi Yen, R, Struys, E A, Koolen, S L W, Dirven, C M F, Leenstra, S, French, P J & Lamfers, M L M 2021, ' Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell cultures ', Neuro-oncology advances, vol. 3, no. 1, vdab103 . https://doi.org/10.1093/noajnl/vdab103
Neuro-oncology advances, 3(1):vdab103. Oxford University Press
Neuro-Oncology Advances
Neuro-oncology Advances
Background Mutations of the isocitrate dehydrogenase (IDH) gene occur in over 80% of low-grade gliomas and secondary glioblastomas. Despite considerable efforts, endogenous in vitro IDH-mutated glioma models remain scarce. Availability of these model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5f6d073950160a1be8293798e386bf
https://pure.eur.nl/en/publications/45e60580-a703-4ccb-8ad9-9d6ffd013b14
https://pure.eur.nl/en/publications/45e60580-a703-4ccb-8ad9-9d6ffd013b14
Autor:
Mehrnaz Ghazvini, Eric M.J. Bindels, Ivo P. Touw, Paulina M. H. van Strien, Vincent H.J. van der Velden, Remco Hoogenboezem, Dennis Bosch, Pier G. Mastroberardino, Emma de Pater, Hans de Looper, Onno Roovers, Sander Barnhoorn, Patricia A. Olofsen
Publikováno v:
Blood Adv
Blood advances, 5(3), 775-786. American Society of Hematology
Blood advances, 5(3), 775-786. American Society of Hematology
Mutations in ELANE cause severe congenital neutropenia (SCN), but how they affect neutrophil production and contribute to leukemia predisposition is unknown. Neutropenia is alleviated by CSF3 (granulocyte colony-stimulating factor) therapy in most ca